Pharmacology Cholinergic/adrendergic Drugs And Blockers

Front 1

Cholinergic drugs mimic

a) parasympathetic
b) ACh
c) rest & digest

Back 1

ALL

Front 2

Receptors that cause vasoconstriction, decreases intestinal and glandular function, and mydriasis

a) Alpha1
b) Beta 1
c) Beta 2

Back 2

Alpha 1

Front 3

Increases HR/Force of Contraction

a) Alpha1
b) Beta 1
c) Beta 2

Back 3

Beta 1

beta blockers tx hi BP

Front 4

increases renin secretion

a) Alpha1
b) Beta 1
c) Beta 2

Back 4

Beta 1

Beta Blockers- Tx BP

Front 5

why are Beta 1 blockers used to treat hi BP?

Back 5

because Beta1 receptors increase HR and Contractile forces of the HT which will increase BP. Thus blocking will decrease

Front 6

Relaxes airways

a) Alpha1
b) Beta 1
c) Beta 2

Back 6

Beta 2

Front 7

Beta 2 receptors cause vasodilation/relaxation of arterioles and veins except for ______________

Back 7

skin
brain

Front 8

Which is not a cholinergic drug

a) Ambenomium chloride (Mytelase)
b) Physostigmine salicylate (Antilirium)
c) Glycopyrrolate (Robinul)

Back 8

Glycopyrrolate (Robinul)- cholinergic blocking

inhibits muscarinic actions of ACh- sub for atropine

Front 9

diagnostic test for Myasthenia Gravis. Why?

Back 9

edrophonium chloride (tensilon)

bc too short acting

Front 10

most cholinergics can be reversed by ___________

Back 10

quinidine
procainamide

Front 11

Which Cholinergic does not inhibit the destruction of ACh but instead mimics ACh by binding to muscarinic receptors

a) Ambenomium (Mytelase)
b) Bethanecol (Urecholine)
c) Neostigmine Br (Prostigmin Bromide)

Back 11

Bethanecol (Urecholine)- urine- creates automatic bladder and increases peristalsis- tx neurogenic bladder, ab distention

Front 12

Cholinergic that prevents Urinary Retention due to Nuerogenic Bladder

a) Edrophine (Tensilon)
b) Bethanecol (Urecholine)
c) Neostigmine Br (Prostigmin Bromide)

Back 12

Bethanecol (Urecholine) - binds to muscarinic rcptrs- mimics ACh

Front 13

Cholinergic that treats myasthenia gravis and post operative ileus but is not often tolerated well

a) Edrophine (tensilon)
b) Physostigmine Salicylate (Antilirium)
c) Neostigmine Br (Prostigmin Br)

Back 13

Neostigmine Br (prostigmin br)

sub w Ambenonium Cl (mytelase)

Front 14

Pyridostgmine Br (Mestinon) is a cholinergic used to Myasthenia Gravis, however, its use may be avoided due to risk of

a) Urinary Retention
b) Hallucination
c) Convulsion

Back 14

Convulsion, Bradycardia, Hypotension

also: HA, miosis, ab cramps, N/V, rash, bronchospasm (common w all cholinergics)

Front 15

Why are most Cholinergics CI for asthmatic px

Back 15

most cause bronchospasm or constriction

Front 16

cholinergic that may also cause hallucinations, and ataxia

a) Physistigmine Salisylate (Antilirium)
b) Atropine Sulfate
c) Pyridostigmine Br (Mestinon)

Back 16

Physistigmine Salisylate (Antilirium)

Atropine Sulfate -> urinary retention, constipation
Pyridostigmine Br (Mestinon) -> bradycardia, hypotension, convulsions

Front 17

why would full stock of Physostigmine Salicylate (Antilirium) be found in rural hospitals but not in urban hospitals?

Back 17

bc it is an antidote in anticholinergic poisoning from insectisides

Front 18

used to speed up HR by blocking vagal effects on the SA node

a) Atropine Sulfate
b) Biperiden Lactate (Akineton)
c) Ephedrine sulfate

Back 18

Atropine Sulfate- used in surgery- may cause urinary retention, constipation, restlessness

(also decreases secretions)

Front 19

Balance Cholinergic activity in Basal Ganglia to treat disorder of coordination/posture including parkinsonism

a) Biperiden Lactate (akineton)
b) Glycopyrrolate (rubinol)
c) Scopalamine Hydrobromide

Back 19

Biperiden Lactate (akineton)

Front 20

used to treat spastic states and motion sickness but should be avoided w alcohol

a) glycopyrrolate (rubinol)
b) atropine sulfate
c) scopalamine hydrobromide

Back 20

scopalamine hydrobromide- Cholinergic blocker - inhibits muscarinic actions of Ach

Front 21

stim both alpha and beta adrenergic receptors to treat bronchospasm, hypersensitivities, and anaphylaxis

a) Epinephrine Hydrochloride (adrenalin)
b) Ephedrine Sulfate
c) Dobutamine Hydrochloride (Dobutrex)

Back 21

Epinephrine Hydrochloride (adrenalin)


Ephedrine Sulfate- alpha and beta receptors -tx asthma, decongest, correct hypotensive state

Dobutamine Hydrochloride (Dobutrex)- Pressor Agent- stim Beta1 receptors of HT to increase myocardial contractility, SV, CO

Front 22

Sudafed stimulates

a) Alpha and Beta Adrenergic receptors
b) Alpha
c) Beta 1
d) Beta 2

Back 22

alpha receptors in respiratory tract producing vasoconstriction. Tx for nasal congestion

Front 23

Stim dopaminergic, alpha and beta adrenergic receptors used to tx shock

a) Adrenalin
b) ephedrine
c) dopamine HydroCl

Back 23

dopamine hydrochloride (intropin)
also increases perfusion to Vital Organs, KD, and increases CO

may cause ectopic beats, hypertension, piloerection, chest pain, dyspnea

Front 24

bronchodilators such as albuterol (ventolin) stimulate

a) Alpha and Beta Adrenergic receptors
b) Alpha
c) Beta 1
d) Beta 2

Back 24

Beta 2- relax bronchial smooth muscle

Front 25

T/F

Adrenalin affects everything the nervous system controls

Back 25

T

esp- nervousness, HA, tachycardia, hyperglycemia, pulm hypertension/edema, pallor, cold extremities

Front 26

Adrenergic Blocker (sympatholytic)

a) dopamine hydrochloride (intropin)
b) propanolol hydrochloride (inderal)
c) metaproterenol (alupent)

Back 26

propanolol hydrochloride (inderal)- most popular Beta Blocker

also DHE 45, Imitrex

Front 27

Adrenergic Blockers are typical used to treat _____

Back 27

tx migraines

DHE45
Imitrex
Inderal = most common beta blockers for hypertension

Front 28

Sumatriptan Succinate (imitrex) is a seratonin ______

Back 28

agonist

Front 29

DHE45 will releive a migraine but may cause

a) painful extremities
b) paresthesia
c) urinary retention

Back 29

painful extremities/weak
paresthesia
tachycardia
hypertension
chest pain
N/V

(NO urinary retention)

Front 30

Sumatrin Succinate (imitrex) can relieve acute Migraines but is used w caution due to which adverse effects

Back 30

Coronary Vasospasm
arrhythmias
chest pain
MI

CI- ischemic HT Disease treated w Nitrates

Front 31

px with ischemic HT Disease that is being treated w Nitrates should not take _______

Back 31

Sumatriptan Succinate (Imitrex)- adrenergic blocker - can cause Myocardial Infarct (MI)