Pathology Of The Pituitary Gland

Front 1

What is shown?

Describe the nuclei, cytoplasm, what are the three possible stains?

Back 1

Front 2

What is T and G?

Back 2

T = thyrotroph cell

G = growth hormone cell (GH cells)

EM on pituitary adenomas not really done anymore

Front 3

These are all causes of what?

Back 3

Hypopituitarism

Front 4

What lobe does infarction involve? Why?

How much of the lobe must be lost for symptoms to occur?

Back 4

Front 5

What are the four causes of pituitary infarction?

What is Sheehan syndrome?

Back 5

Sheehan = peripartum infarct of pituitary gland (pituitary gland enlarges during pregnancy becomes more vascularized and more sensitive to blood loss)

Front 6

What are some symptoms of Sheehan syndrome? When will you see it?

Back 6

1 month later because it takes a while before 75% of the anterior pituitary is lost

Front 7

What is the gland? What are the two arrows pointing at?

Back 7

Front 8

Is the pituitary infarct above or below the line?

Back 8

Front 9

What is happening? What type of necrosis? What are the only viable cells?

Back 9

Front 10

What are the three types of inflammatory lesions?

Back 10

Front 11

What is the gland? What is going on? What is lacking around the rim of the granulomas? Where do they usually locate?

Back 11

Non-caseating granuloma

Front 12

What does TB of the peripheral nervous system preferentially attack?

Back 12

BASAL cells of brain (don't confuse with sarcoidosis or TB) => DON'T WANT TO GIVE IMMUNOSUPPRESSIVES TO SOMEONE WITH TB!!!

Front 13

What is this?

Back 13

Front 14

What are the four disease of hyperpituitism?

Back 14

Front 15

Pituitary hyperplasia:

Common or uncommon

Two main types

What type of gland involvement?

Increase in what?

What is an example? Disease?

Back 15

Front 16

What is the most common cause of hyperpituitarism? They are what percent of intracranial neoplasms?

Most common in what ages?
Are they usually isolated or multiple? Can be part of what syndromes?

Back 16

Front 17

What is this? What are the two small tan structures on either side of the tumor?

How could you get to a pituitary adenoma surgically without removing the top of the skull and the brain?

How do you take this thing out?

Back 17

Pituitary adenoma in sella turcica

Optic nerves being pressed => bilateral vision problems

Transnasally

Front 18

What is the most common presenting sign of non-functional pituitary adenoma?

Back 18

Headache

Front 19

Back 19

Front 20

Congested, hemorrhagic pituitary adenoma. What is the white strip lateral to the tumor? What symptoms will the patient have?

Back 20

Front 21

What are the pituitary adenoma types in order of most common to least common?

Back 21

Front 22

Look over

Back 22

Front 23

What is a pituitary adenoma producing prolactin? What is it the most common type of?

What is the mutation associated with it?

Two symptoms?

Back 23

Front 24

What is this the histopathology of?

Back 24

Pituitary prolactinoma

Front 25

What is the gland? Disease? Describe.

Back 25

Front 26

Left and right?

Back 26

Left = monomorphism => prolactinoma

Right = normal

Front 27

What is SIADH caused by? Which lung tumor specifically?

Three symptoms?

Back 27

Front 28

DI is a deficiency of which part of the pituitary gland?

What will the plasma Osm show?

Back 28

Front 29

What is slow-growing neoplasm though to arise from vestigial remnant of Rathke pouch?

What percent of intracranial tumors?

Ages? Bimodal?

What are the two types?

What do patients present with?

Abnormalities of what signaling pathway?

Back 29

Front 30

Identify 1, 2, and 3.

What is the diagnosis?

Back 30

1 = wet keratin (looks like a keratin pearl with edema)

3 = cholesterol rich area from the wet keratin pearl