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15 Cards in this Set

  • Front
  • Back

Somitogenesis

Cranio-caudal Reorganisation and segmentation of paraxial

Somitogenesis time frame

First pairs appear @day 20


4 simites @ day 21


42-44 final pairs @ day 30

Occipital somites derivatives

4 pairs


Occipital part of skull


Bones around nose, eyes and inner ear


Extrinsic ocular muscles


Muscles of tongue

Cervical somite derivatives

8 pairs


Occipital bone


Cervical vertebrae and muscles


Part of dermis


Part of upper arm musculature

Thoracic Somites derivatives

12 pairs


Vertebrae


Part of upper arm musculature


Thoracic Dermis


Muscles and bones of thoracic wall


Part of abdominal wall


Lumbar somite derivatives

5 pairs


Lumbar vertebrae


Abdominal muscles and dermis


Leg musculature

Sacral Somites derivatives

Sacrum


Dermis


Musculature

Coccygeal Somites derivatives

8-10 pairs ( majority degenerate 3-5 final)


Coccyx


Dermis


Musculature

Somite Differentiation

2 populations


Dorsal - remain epithelial cells - form Dermomyotome


Ventero-medial - Mesenchymal cells- form Sclerotome


- populate space around notochord and neural tube-》 form vertebrae and ribs


Notochord will regress and disappear

Sclerotome

Populate space around notochord and neural tube


- form vertebrae and ribs

Dermomyotome


2 p derivatives

Dorsal portion , epithelial cells


Myotome:


- cells migrate laterally to form distinct muscle masses


-》 trigger the development of the motor innervation from the spinal cord


- Epaxial (Dorsal) and Hypaxial (Ventero-lateral) muscles of trunk


- some cells invades developing limbs-》 limb musculature


Dermatome:


Forms the dermis of the skin


Sensory info. Reflects Somatic organisation

Myotome

Derivative if Dermomyotome


Group of muscles that a single spinal nerve innervates



Cells from each myotome migrate laterally to form distinct muscle masses that will trigger the development of the motor innervation from the spinal cord.– Epaxial (dorsal) and hypaxial (ventrolateral) muscles of the trunk– Some cells also invade developing limbs to form limb musculature

Dermatome

Derivative of Dermomyotome


An area of skin a single spinal nerve innervates


Forms the dermis of the skin

Epaxial muscles

Dorsal


Around vertebrae

Hypaxial

Ventral to vertebrae