Lorenzo Odone

INTRODUCTION The movie Lorenzo’s oil portrays an inherited genetic disorder which is Adrenoleukodystrophy (ALD). It is a syndrome called Addison disease with an X-linked recessive gene and cerebral sclerosis (Bruckeim, A.H.M.D, the family Doctor, Educators Advantage, 1994). This disease is caused by the abnormal build-up of very long-chain of saturated fatty acids (VLCFA), hexacosanoic acid (C26:0) and teracosanoic acid (C24:0) (Moser et al, 2007) in the tissues, body fluids (Igarashi et al, 1976), the adrenal glands and brain (cerebral white matter) ,(Woodrow Wilson Biology institute,1994). On a protein level, ALD is triggered by ATP-binding cassette transporter subfamily D member 1(ABCD1) gene coding for a peroxomal membrane protein (Moser et al, 2005). Moreover, it is also caused by a single mutation at the locus Xq28 causing deficient activity of necessary enzyme ligase. The disease symptoms usually develop as a result to the abnormality of perixomes in the liver, which ultimately disrupts fatty acid metabolism and affect very long chain fatty acids causing them to be abnormal (“Lorenzo’s oil”; MCA Universal Studio,1992). Different forms of the disease Adrenoleukodystrophy can be found in three types of ALD; Adolescent cerebral X-ALD which is effective at the age of 10-21 years and cause behavioural and neurological deficits, Adrenomyeloneuropathy is effective at the age of 19-37 years and causes spinal cord paralysis and Adult cerebral X-ALD which is effective after 21…

Lorenzo’s Oil In the Lorenzo’s Oil, a boy named Lorenzo is diagnosed with Adrenoleukodystrophy (ALD). ALD is a genetic disorder that affects 1 in every 18,000 people. It mostly affects boys. The disorder destroys myelin, which is the protective part of the brain that surrounds the neurons. Lorenzo’s family had courage and persistence which inspired me. Michaelia shouldn’t feel guilty that it was her genes that caused Lorenzo to have ALD. I believe that everyone needs people to help them at…

As a result Frank Lorenzo took over operations and demanded lower labor cost with wage cuts and layoffs in order to save the company. Despite the merger with Texas Air, Continental went into bankruptcy in order to reorganize and get out of existent contracts. With lower wages restrictions and expansion to the eastern, western and the Great Plains region due to actuation of People Express and Frontier, Continental became one of the largest airlines in the United States. As a result of Lorenzo’s…

fostered a war zone within Venice. Aspiring artists hoped to cement their legacy as the likes of Giovanni Bellini or Raphael, but few managed to achieve what Titian did. Critics rave over Titian’s vibrant use of color and his masterful brushstroke. Many studied under Titian, but where was their success? Why was there seemingly such a remarkable barrier of skill between Titian and those below him? Three works of art on display at The MET’s Gallery 607 allow for a great analysis of what really…

Symbol Example from story Importance Act 1: Nature “Look like the innocent flower, but be the serpent under it.”- Lady Macbeth (Act 1 scene 5 line 72-73) “The air nimbly and sweetly recommends itself unto our gentle sense.” - King Duncan (Act 1, Scene 6, Line 1-2) “... heaven’s breath smells wooingly here.” - Banquo (Act 1, Scene 6, Line 6-7) All of these lines compare Macbeth to something in nature. Lady Macbeth’s line says that Macbeth needs to look like a flower but really be a snake deep…

La Primavera was created for the cousin of Lorenzo the Magnificent, Lorenzo di Pierfrancesco de’ Medici. It could be seen as some sort token of appreciate for being forced into marriage. The original date of this painting is uncertain but has been narrowed down to between 1477 and 1482. It is documented that this painting was hung in the bedroom of the bride Semiramide Appiani. By understand the background of this painting it opens the door for ample interpretation which is pretty beautiful.…

considered to be the focus of what came to be the Renaissance. The political realm of Florence was dictated by the Medici family. This family controlled the city in secret, for nearly eight decades. The family saw the city of Florence as their work of art One member of this family was Cosimo de’ Medici. Cosimo embraced the very essence of what humanism is. Humanism embraces the arts and literature from cultures of Ancient Greece and Rome. Cosimo made sure that he was constantly around…

The Prince was a book that was written by Niccolo Machiavelli . Machiavelli was an Italian diplomat to several European courts. Machiavelli wrote The Prince in dedication to the prince of Italy at the time: Lorenzo De Medici. The Prince is a book about royals written by a commoner who was better informed on the matters of the royals. Machiavelli asserted that The Prince was the aggregation of the knowledge he had acquired over time through many difficulties, sometimes in dangerous ways as he…

Renaissance, It is most famous for the Italian Art Masters such as Da Vinci, Michelangelo and Raphael. These remarkable artists made art no longer a craft being made by craftsmen, on the contrary art became an almost noble like statues, something perceived as valuable and glorious. These Italian master arose in the time when Italy was in need of prestige and honorable buildings and in a time were artists no longer had to accommodate to the wishes of the their commissioner but to their own…

the death of Giovanni, Cosimo de’ Medici, took control of the bank and expanded the trade by capitalizing on wool and cloth industries and opening up deposit accounts and bills of exchange (“Medici Bank”). Cosmo’s power derived from his great wealth as a banker, his patronage of the arts and success in learning. Uninterested in Politics and second in Command to his brother, Giovanni the II devoted his time to the bank, however used the banks’ success and wealth to his benefit using the money to…