Adrenoleukodystrophy

Adrenoleukodystrophy (ALD) is a condition which affects the ability of adrenal glands to produce adrenaline and myelin, which insulates the nerves in the brain and spinal cord. This diminishes the ability of the brain to communicate effectively with the rest of the nerves. This condition was initially identified in the early 1900s and was originally called Schilder-Addison disease (2). The cause of this condition originates in the peroxisomes, which are tiny structures in the cell which assist cells in the fatty acid break down process. When peroxisomes cannot perform the breakdown of Very Long Chain Fatty Acids (VLCF), complications will eventually appear; leading to the accumulation of VLCF in the adrenal organs. According to Thomas C.…

INTRODUCTION The movie Lorenzo’s oil portrays an inherited genetic disorder which is Adrenoleukodystrophy (ALD). It is a syndrome called Addison disease with an X-linked recessive gene and cerebral sclerosis (Bruckeim, A.H.M.D, the family Doctor, Educators Advantage, 1994). This disease is caused by the abnormal build-up of very long-chain of saturated fatty acids (VLCFA), hexacosanoic acid (C26:0) and teracosanoic acid (C24:0) (Moser et al, 2007) in the tissues, body fluids (Igarashi et al,…

Lorenzo’s Oil In the Lorenzo’s Oil, a boy named Lorenzo is diagnosed with Adrenoleukodystrophy (ALD). ALD is a genetic disorder that affects 1 in every 18,000 people. It mostly affects boys. The disorder destroys myelin, which is the protective part of the brain that surrounds the neurons. Lorenzo’s family had courage and persistence which inspired me. Michaelia shouldn’t feel guilty that it was her genes that caused Lorenzo to have ALD. I believe that everyone needs people to help them at…

Peroxisomes and Adrenoleukodystrophy Adrenoleukodystrophy, or ALD, is a rare genetic disorder in which the myelin sheath surrounding nerve cells in the brain breaks down, and the adrenal gland progressively loses function.(medical dictionary. Myelin sheaths coat nerves to speed up and strengthen neural impulses. If the myelin malfunctions, many neural messages will not do what they should. ALD primarily affects boys and men. It is extremely rare, only 1 in every 100,000 people are afflicted.…

Neonatal Adrenoleukodystrophy, or NALD, is an autosomal recessive disease involving the defective growth of the adrenal glands and white matter in the brain. As an intermediate on the PBD-Zellweger syndrome continuum, NALD is marked by limited psychomotor development, facial dimorphisms, seizures, in addition to visual and auditory impairments; being fatal in some cases. Its peroxisomal deficiencies impart the presence of defects in plasma very long chain fatty acid levels, bile acid, and…

Adrenoleukodystrophy also known as ALD is a genetic disease. This is a brain disorder where the myelin in the brain gets destroyed and one will have an unusual amount of saturated fatty acids. When the myelin gets destroyed the neurons in the brain start to stop telling the central nervous system what to do. At first a person will show behavior changes but as the disease progresses the symptoms become worse; causing people to become blind, deaf, experience weight loss, have seizures, and even…

the Cell Assignment: Heart-Hand syndrome & X-linked Adrenoleukodystrophy Heart-Hand Syndrome is also known as Holt-Oram Syndrome, where individuals are born with skeletal abnormalities of hand and arms (upper limbs) and heart problems due to the mutation of HOS1into the TBX gene. TBX gene plays a role in controlling growth of bone in the hand and arm. Also, TBX is present in chromosome 12. The symptoms include: missing thumbs, long thumb that looks a like a finger, partial or complete absences…

the Odone family who is going through a hard time due to the sickness of Lorenzo. Lorenzo is the son of Augusto and Michaela Odone. Their son has an illness called Adrenoleukodystrophy, otherwise known as ALD. ALD slowly shuts down all of your bodily functions essentially to the point where you die. With no cure, the hope of Lorenzo surviving was slim. However, Augusto and Michaela decided to do everything in their power to save their son from such a lethal illness. The Odones spent countless…

There are three steps to diagnosing PAI. 1. Mid-morning blood assay may show elevated plasma adrenocorticotropic hormone ACTH and plasma renin activity PRA with decreased serum cortisol and serum aldosterone and dehydroepiandrosterone sulphate DHEAS [1, 3]. ACTH and cortisol concentrations have a diurnal variation that differs in patients with PAI. 2. Is to exclude secondary conditions that result in adrenal insufficiency such as HIV and tuberculosis [2,3]. 3. If autoantibodies are negative,…

 This movie also shows, how much a family loves their kid in order to treat him from this deadly disease.  Their dedicated research find the medicine for a deadly disease called adrenoleukodystrophy (ALD) and they named after the medicine their own sons name as “Lorenza’s Oil”.  It also shows all the struggles which Lorenzo’s parents are facing, including the personal /family struggles of Augusto and Michaela Odone when they try to find a solution for ALD to comfort their own son  After…