Rbc Morphology

Front 1

Anisocytosis

Back 1

Variation in the size of cells.

Front 2

Poikilocytosis

Back 2

Variation in the shape of cells.

Front 3

Microcyte

Back 3

RBC less than 6 microns.

Front 4

Macrocyte

Back 4

RBC bigger than 8 microns.

Front 5

Normocyte and another name

Back 5

RBC that contains less than normal amount of hemoglobin. Aka discocyte.

Front 6

Hypochromic erythrocyte

Back 6

RBC that contains less than the normal amount of hemoglobin.

Front 7

Normochromic erythrocyte

Back 7

RBC that contains the normal amount of hemoglobin.

Front 8

Polychromasia

Back 8

Erythrocytes that exhibit a gray blue staining on a wright stained smear due to the presence of the ER and RNA.

Front 9

Anisochromasia

Back 9

RBC that has an uneven hemoglobin concentration.

Front 10

Dimorphic population

Back 10

RBCs that are of two distinct sizes on a peripheral smear.

Front 11

Acanthocyte and other names

Back 11

Unevenly spaced bulbous projections. Aka thorn cell or spur cell.

Front 12

Crenated cell and another name

Back 12

Evenly spaced rounded projections. Aka berry cell.

Front 13

Burr cell and another name

Back 13

Evenly spaced pointed projections. Aka echinocyte.

Front 14

Spherocyte

Back 14

Cell that has no central pallor; spherical in shape; appearance is hyperchromic.

Front 15

Target cell and other names

Back 15

Has central area of hemoglobin pigment surrounded by a relatively clear area and a peripheral rim of hemoglobin; may be an extension of the peripheral rim of hemoglobin to the center of the cell. Aka codocyte or mexican hat cell.

Front 16

Sickle cell and other names

Back 16

Thin, elongated RBC with a point at each end; may have oat, crescent, "L", "V", or "S" shapes.

Front 17

Stomatocyte

Back 17

Has an oval or rectangular area of central pallor. Resembles mouth.

Front 18

Elliptocyte

Back 18

Cigar shaped RBC. Has little to nothing area of central pallor.

Front 19

Ovalocyte

Back 19

Egg shaped RBC. Has an oval shaped area of central pallor.

Front 20

Teardrop cell and other names

Back 20

Has one pointed projection causing the cell to be teardrop in form. Aka pear cell, pointed cell, and dacryocyte.

Front 21

Tail cell and another name

Back 21

Has one projection that is not pointed. Aka filamented cell.

Front 22

Schizocyte and another name

Back 22

Fragmented RBC.

Front 23

Rouleaux formation

Back 23

RBCs that are connected in rows that look like toppled stacks of coins.

Front 24

Agglutination and another name

Back 24

RBCs that are clumped together. Aka autoagglutination.

Front 25

Folded cell and another name

Back 25

RBCs that appear to have one side folded inward.

Front 26

Spheroidocyte

Back 26

RBC that has an eccentric area of pallor.

Front 27

Blister cell and another name

Back 27

RBC that has a vacuole that appears like a blister. Mass (Howell jolly body) is taken out leaving a colorless hole. Aka marginal achromatic cell.

Front 28

What cells do blister cells give rise to?

Back 28

Helmet cell and keratocyte.

Front 29

Helmet cell

Back 29

Cellular element remaining after the rupture of a blister cell.

Front 30

Keratocyte

Back 30

Has two spicules that resemble horns; formation due to rupturing of a blister cell.

Front 31

Pinchered cell and other names

Back 31

Almost look like mushrooms. Aka pinched or knizocyte.

Front 32

Howell jolly body

Back 32

Spherical nuclear fragments (DNA); usually only one present; stains dark blue to purple; normally pitted from RBC during passage through spleen.

Front 33

Basophilic stippling

Back 33

Tiny, round, solid-staining dark blue granules representing aggregates of RNA.

Front 34

Course basophilia is referred to as _________________.

Back 34

Punctuate stippling.

Front 35

Pappenheimer bodies are same as _____________, but use different stain.

Back 35

Siderotic granules.

Front 36

Pappenheimer bodies

Back 36

Usually seen as purple dots. Usually clustered together and generally near the periphery of cell.

Front 37

Confirmation of siderotic granules

Back 37

Confirmation of being iron (ferric Fe3+) bodies is demonstrated using Prussian blue stain.

Front 38

Sideroblast

Back 38

Prussian blue stained nucleated erythrocytes that contain iron, regardless of maturation.

Front 39

Ringed sideroblast

Back 39

Nucleated erythrocytes that have a cluster of iron granules around the nucleus.

Front 40

Cabot rings

Back 40

Ring shaped or figure eight shaped structures; may represent micro tubules from mitosis or nuclear remnants.

Front 41

What stain is used to demonstrate the reticulum of a polychromatophilic erythrocyte?

Back 41

Supravital stain - New Methylene Blue N.

Front 42

What do reticulocytes reflect?

Back 42

Activity of bone marrow.

Front 43

Heinz bodies

Back 43

Inclusions that represent denatured hemoglobin. May be one or more and usually seen bound to the membrane.

Front 44

How do Heinz bodies appear in a Wright's stain?

Back 44

Darker areas within the cells.

Front 45

How are Heinz bodies best demonstrated?

Back 45

By incubating cells in acetylphenylhydrazine, then stained with a supravital stain.

Front 46

Hemoglobin C crystals

Back 46

Rod shaped or angular opaque structures within erythrocytes.

Front 47

What do hemoglobin C crystals represent?

Back 47

Beta chains of Hgb A.

Front 48

What can hemoglobin C crystals be induced with?

Back 48

Addition of 3% NaCl.

Front 49

Hemoglobin SC crystals

Back 49

Often curved and have blunt ends. Often a chromophobic area between darker ends.

Front 50

What does a reticulocyte contain?

Back 50

RNA

Front 51

What does basophilic stippling contain?

Back 51

RNA.

Front 52

What does a Howell jolly body contain?

Back 52

DNA.

Front 53

What does a siderotic granule contain?

Back 53

Iron.

Front 54

What does a Pappenheimer body contain?

Back 54

Iron.

Front 55

What does a Heinz body contain?

Back 55

Denatured hemoglobin.

Front 56

Stain used to see a reticulocyte

Back 56

New Methylene Blue N.

Front 57

Stain used to see basophilic stippling

Back 57

All.

Front 58

Stain used to see Howell Jolly body

Back 58

All.

Front 59

Stain used to see siderotic granules

Back 59

Prussian blue.

Front 60

Stain used to see Heinz bodies

Back 60

Crystal violet or brilliant cresyl blue.

Front 61

Supravital stain

Back 61

Stain that is used when cells are still alive.

Front 62

What morphology do you view on 10x?

Back 62

Rouleaux, agglutination, platelet clumps on edge, distribution of cells, and staining quality.

Front 63

What morphology is viewed on 50x?

Back 63

If RBCs appear normal, no further evaluation needed. If abnormalities found, switch to 100x.

Front 64

How many fields are viewed when doing differentials?

Back 64

10.

Front 65

A minimum of ____________ cells should be observed when doing a differential.

Back 65

150-200.

Front 66

Where should you view the blood slide?

Back 66

Where RBCs aren't touching.

Front 67

Which cells are significant in high numbers?

Back 67

Micro/macro cytes, hypochromasia, target cells, burr cells, ovalocytes, and stomatocytes.

Front 68

1+ cell count in high numbers

Back 68

10-50 or 5-25%.

Front 69

2+ cell count in high numbers

Back 69

51-100 or 25-50%.

Front 70

3+ cell count in high numbers

Back 70

100 or 50%.

Front 71

1+ cell count in low numbers

Back 71

1-2 or up to 1%.

Front 72

2+ cell count in low numbers

Back 72

2-5 or 1-2.5%.

Front 73

3+ cell count in low numbers

Back 73

5 or 2.5%.

Front 74

What morphology is reported if present?

Back 74

Cabot rings, malarial parasites, and hgb c crystals.