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24 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Dosage form contained within and dissolution should occur within |
Basket apparatus |
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pH change in basket apparatus is by ____ |
Media exchange |
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Dosage form should remain at the bottom center of the vessel |
Paddle |
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pH change in paddle apparatus is ____ |
By media addition |
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The vessel is immersed in water bath holding temperature at 37.5°C |
Reciprocating cylinder |
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This apparatus is consist of a reservoir for the dissolution medium and a pump that forces medium through the cell holding the test sample |
Flow through cell type |
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Its dissolution fluid is collected in separate reservoir |
Flow through cell |
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It is useful for drugs with low solubility, powders, granules, and implants |
Flow through cell |
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Standard volume of paddle over disk |
900 mL |
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The disk assembly of paddle over disk restricts the ____ |
Patch size |
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Operating temperature of cylinder |
32°C |
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The assembly consists of a set of volumetrically calibrated or tared solution containers |
Reciprocating disk |
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The solution containers are partially immersed in a suitable water bath inside the temperature of the containers at 32.5°C |
Reciprocating disk |
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4 physicochemical properties of the drug |
Polymorphic form Particle size Salt form Hydrates and anhydrates |
PPSH |
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4 factors related to tablet manufacturing |
Amount and type of binder Method of granulation Type of disintegrants Compression lod |
AMTC |
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5 factors related to method of dissolution study |
Type of dissolution equipment Temperature Volume of dissolution Intensity of agitation Sink or non sink conditions |
TTVIS |
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Measures the degree of force needed to fracture a tablet |
Tablet hardness |
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The ability of compressed tablets to avoid fracture and breaking |
Friability test |
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Acceptance criteria of coated tablets in Friability test |
% friability should NMT 1% |
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Acceptance criteria of compressed tablets in Friability test |
% weight loss should be between 0.5-1% |
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It minimizes appearance problems |
Tablet thickness |
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USP requirement of tablet thickness |
More than 12.50mm, the deviation should not exceed 3% |
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USP requirement of Tablet thickness 2 |
Less than 12.50mm, the deviation should not exceed 5% |
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Ha |
Ha |
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