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75 Cards in this Set

  • Front
  • Back
Synovial osteochondromatosis

Case findings:
Multiple calcifications in within the region of the synovium
Erosion of the femoral head

Formation of multiple cartilaginous nodules within the synovium
Well defined bony erosions may be seen
Primary: synovial metaplasia
Secondary: MC due to osteoarthritis

MC finding is multiple rounded calcified or ossified loose bodies in the synovium
Appear as rounded densities with central lucencies
Complication:
Malignant transformation to synovial chondrosarcoma
Unicameral bone cyst

Case findings:
Radiolucent lesion with sclerotic margins
Mild cortical thinning
Mild osseous expansion of the body of the calcaneus

DDX:
Intrasosseous lipoma: may see central calcification
Pseudotumor: thinning of the trabeculae
Fibromatosis

Case findings:
XR:
Areas of lucency, cortical thinning, and bony remodeling within adjoining portions of the distal right radius and ulna
Periosteal elevation along volar aspect of both bones
MRI:
Soft tissue mass centered in the interosseous membrane and flexor compartment of distal right forearm
Mass is predominantly dark on both T1 and T2
Enhances heterogeneously
DDX:
Fibromatosis
Fibrosarcoma
MC ST malignancy in neonate and young infant
Rhabdomyosarcoma
Older children and commonly arise from muscles of the extremities
Signal characteristics  similar to muscle
Not usually low signal on T1/T2
Synovial cell sarcoma
MC in 3-5th decade
Similar imaging features as fibromatosis
Benign lesion that never metastasizes but can be locally aggressive
Classification:
Superficial: small and slow growing
Deep: generally more aggressive

MC low T1 and T2 (fibrous nature)
Enhancement is variable, ranges from none to diffuse
Scleroderma (progressive system sclerosis)

Case findings:
Resorption of the distal phalanges

Classic:
ST calcification
Atrophy of the finger tips (tapering)
Autoamputation of the terminal tufts (pencil-in-cup deformity)
Intercarpal joint space narrowing

DDX acro-osteolysis (PINCHFO)
Psoriasis, sarcoidosis
Injuries: frostbite, thermal injury, post-traumatic
Neuropathic: DM, leprosy, chronic insensitivity to pain, Lesch-Nyan syndrome
CVD: scleroderma
Hyperparathyroidism
Familial/congenital: Hajdu-Cheney
Occupational: polyvinyl chloride exposure
Melorheostosis 

Case findings:
Multiple areas of increased bone density 
Marked thickening of the lateral femoral cortex, which has a somewhat undulating medial margin 
Dripping wax appearance to the margins of the hyperostotic bone in the 2nd - 4th
Melorheostosis

Case findings:
Multiple areas of increased bone density
Marked thickening of the lateral femoral cortex, which has a somewhat undulating medial margin
Dripping wax appearance to the margins of the hyperostotic bone in the 2nd - 4th phalanges

Frequently distributed along a single sclerotome
Bone scan: appearance similar to Paget’s
Often crosses joints and may result in flexion contractures
Pellegrini-Stieda

Calcification or ossification of the MCL at its insertion on the medial femoral condyle
Hyperparathyroidism

Case findings:
Multiple lytic and somewhat expansile lesions with well-defined borders
Subperiosteal resorption is present along the radial aspect of the proximal and mid phalanges
Brown tumors (osteoclastomas):
Multiple well margined lytic lesions
MC eccentric and cortical in location
DDX: enchondroma
Erosive inflammatory OA

MC post-menopausal women
STS, bone proliferation with central erosions  sea-gull deformity
May see ankylosis of IP joint (not seen in non-inflammatory OA)

DDX of single joint involvement:
Septic arthropathy
Psoriasis
Erosive osteoarthritis
Adult Still’s disease

Cronkhite-Canada syndrome
Inflammatory polyposis associated with erosive OA
Osteochondroma

Case findings: 
Exophytic expansile lesion in spinous process

Vertebral osteochondroma is MC in posterior osseous elements
Direct continuity of cortex and marrow cavity
Tip of the osteochondroma is covered by hyaline cartilage cap
Osteochondroma

Case findings:
Exophytic expansile lesion in spinous process

Vertebral osteochondroma is MC in posterior osseous elements
Direct continuity of cortex and marrow cavity
Tip of the osteochondroma is covered by hyaline cartilage cap
Osteoblastoma

MC located in the posterior element of the vertebral body

DDX:
Aneurysmal bone cyst
Osteoid osteoma
Osteoblastoma
Ankylosing spondylitis

Case findings:
Ankylosis of SI joints
Syndesmophyte: ossification of annulus fibrosis
Ossification of interspinous ligaments

MC seronegative spondyloarthropathy
Males 15-35 years-old
Extra-articular manifestations:
Iriti
Ankylosing spondylitis

Case findings:
Ankylosis of SI joints
Syndesmophyte: ossification of annulus fibrosis
Ossification of interspinous ligaments

MC seronegative spondyloarthropathy
Males 15-35 years-old
Extra-articular manifestations:
Iritis, aortic insufficiency, UL interstitial lung disease
Sacroiliitis: involves ligamentous and synovial portion of the SI joint
Bamboo spine: from continuous syndesmophytes
Squaring of vertebral bodies
Osteopetrosis (marble bone disease, Albers-Schonberg)

Types: congenital AR lethal, tarda AD benign
Symmetrical generalized dense bones with lack of cortical and medullary differentiation
Bone-in-bone appearance in spine and long bones
Sandwich vertebra sign: increased density at end plates
Diffuse vertebral body sclerosis
Increased density at skull base and calvaria

DDX:
Engelmann’s disease: affects only diaphysis of tubular bone (in contrast, osteopetrosis affects the entire bone)
CPPD deposition disease

CPPD (calcium pyrophosphate dihydrate) deposition leads to
Distinctive gout-like pattern of arthritis (pseudogout)
Structural joint damage (pyrophosphate arthropathy)
Calcification of articular cartilage (knee, hip, shoulder, TFCC, symphysis)
Patello-femoral compartment involvement

Pseudogout arthropathy (similar to OA):
Medial joint space narrowing
Subchondral sclerosis
Osteophyte formation
Chondrocalcinosis
Chondrocalcinosis:
Calcification of hyaline (articular) cartilage or fibrocartilage (menisci)

DDX (“HOGWASH”) of chondrocalcinosis:
Hemochromatosis
Ochronosis
Gout
Wilson’s
Acromegaly
MC pseudogout (CPPD deposition)
Hyperparathyroidism
Aneurysmal bone cyst

Expansile lesion containing thin-walled, blood-filled cystic cavities
MC long tubular bones and spine

DDX lytic lesion in spinous process:
Osteoblastoma
Aneurysmal bone cyst
Osteoid osteoma
Aneurysmal bone cyst

Expansile lesion containing thin-walled, blood-filled cystic cavities
MC long tubular bones and spine

DDX lytic lesion in spinous process:
Osteoblastoma
Aneurysmal bone cyst
Osteoid osteoma
Chondrosarcoma

Case findings:
XR: mixed lytic and sclerotic lesion within the right frontal bone with relatively well-defined sclerotic margins
CT: thickening of the outer table, presence of calcified matrix

May occur as:
Primary bone tumor or
Develop from a pre-existing lesion (e.g., enchondroma)
Pain is a distinguishing feature between enchondroma and chondrosarcoma
Neurofibroma

Case findings:
T1: homogeneously isointense with muscle ovoid mass along the expected course of the femoral neurovascular structures
T2: target appearance with a hyperintense rim and central area of decreased SI

Target appearance (on T2): unique to NF
Dense collagen and fibrous tissue centrally and myxoid material at the periphery
Bone infarct

Case findings:
Patchy areas of lucency and sclerosis
Bone collapse at articular surfaces

Osteonecrosis: encompasses both
AVN: occurs at articular surface (e.g., femoral epiphysis)
Bone infarct: occurs away from articular surface (e.g., diaphysis of long bones)
Discoid meniscus

Sagittal: continuous meniscal signal is seen on three or more sagittal images that are 5 mm thick
Coronal: meniscal tissue extends closer to the notch than a normal meniscus and the height of the discoid meniscus may be 2 mm or greater than the opposite meniscus

MC affects lateral meniscus
GCT of tendon sheath (extra-articular PVNS)

MC slow growing and painless
Bone involvement is rare and no calcification is seen
May have pressure erosions

DDX:
Chronic hemarthrosis
Malignant fibrous histiocytoma
Desmoid tumor
Pigmented villonodular synovitis (PVNS)

Proliferative disorder affecting synovium of joints, bursae, and tendons
Dense hemorrhagic effusion
Hemosiderin deposition

Well-defined erosions 
Nodular synovial masses in a juxta-articular distribution (l
Pigmented villonodular synovitis (PVNS)

Proliferative disorder affecting synovium of joints, bursae, and tendons
Dense hemorrhagic effusion
Hemosiderin deposition

Well-defined erosions
Nodular synovial masses in a juxta-articular distribution (low T1 and variable T2)

NOT seen: osteophytic response
Dorsiflexion intercalated carpal instability (DISI)

Case findings:
Gap of 4 mm between scaphoid and lunate
Lateral XR: dorsal flexion of the lunate
Dorsiflexion intercalated carpal instability (DISI)

Case findings:
Gap of 4 mm between scaphoid and lunate
Lateral XR: dorsal flexion of the lunate
Essex-Lopresti fracture

Comminuted and displaced fracture of the radial head AND
Subluxation or dislocation of the DRUJ 
Due to longitudinal compression force 

Monteggia fracture

Fracture of the ulna and dislocation of the radial head
Monteggi
Essex-Lopresti fracture

Comminuted and displaced fracture of the radial head AND
Subluxation or dislocation of the DRUJ
Due to longitudinal compression force

Monteggia fracture

Fracture of the ulna and dislocation of the radial head
Monteggia fracture MC than Galeazzi fracture
Malgaigne fracture

Case findings:
Fracture of right sacral ala, and right pubic rami

Unstable, vertical shear fracture
Breaks occur at two locations in the pelvic ring (anterior and posterior aspects)

Examples:
Vertical fracture of both pubic rami AND a fracture of the ilium or sacrum or a dislocation of the SI joint
Dislocation of the symphysis with either dislocation of the SI joint or fracture of the sacrum or ilium
Segond fracture

Vertical avulsion fracture of proximal lateral tibia at insertion of the lateral capsular ligament
Occurs with knee in flexion as a result of internal rotation of tibia
Differentiate from avulsion proximal fibula (insertion site of biceps femoris and lateral collateral ligament)

Segond fracture associated with:
ACL tear, meniscal tear
O’Donahue’s triad:
ACL tear, MCL injury, medial meniscus injury
Chondromalacia patella

Case findings:
CT arthrogram (utilizing air as the contrast material): demonstrates superficial irregularity of patellar cartilage

Loss of cartilage over one or more portions of the patella
MC medial facet of the patella
Odd facet (medial aspect of the medial facet) is the MC affected by chondromalacia
Dorsal defect of the patella

Case findings:
Round lytic lesion with sclerotic rim on articular surface of the patella, upper outer quadrant

Variation in normal ossification of the bone
Alternatively, may be related to traction occurring in the insertion site of the vastus lateralis muscle
Appears as radiolucent area in superolateral aspect of patella

DDX:
Chondroblastoma
Osteochondritis
Gout
Maisonneuve fracture

Components:
Fracture of the proximal third of fibula
Rupture of the distal tibiofibular syndesmosis

Associated with:
Fracture of the tibia
Rupture of the deltoid ligament (medial ankle)
Gout

Case findings:
XR:
Focal prominence of ST overlying 1st tarsometatarsal joint
Erosive deformity along medial margin of 1st tarsometatarsal joint
MRI:
Destruction of medial dorsal aspect of medial cuneiform bone with adjacent ST mass
Central necrosis and peripheral gadolinium enhancement

DDX:
Gout
Focal pigmented villonodular synovitis
Soft tissue sarcoma
Amyloid
Giant cell tumor of tendon sheath
Well defined erosions with sclerotic borders or overhanging edges
Soft tissue nodules may calcify in presence of renal failure
Random distribution in hands without marked osteoporosis
Affects 1st MTP joint
40% with gout have concomitant CPPD (look for chondrocalcinosis)
Spontaneous osteonecrosis about the knee (SONK)

Case findings:
Coronal fat-suppressed proton-density and sagittal inversion recovery images
Irregularity of the subchondral bone and subjacent bone marrow edema in medial femoral condyle
Tear of the medial meniscus

Also called Ahlback’s disease
Idiopathic disorder characterized by osteonecrosis and distinct from osteochondritis dissecans
Affects the weight-bearing surfaces of the joint (medial femoral condyle)
Cyclops lesion

Case findings:
Sagittal T2:
Status post ACL reconstruction
Nodular focus of low signal intensity at the posterior aspect of Hoffa's infrapatellar fat pad

Localized form of anterior arthrofibrosis
Complication of reconstruction of the ACL
Located anterior to the graft and may be the result of debris from drilling in preparation of the tibial tunnel, or it may relate to graft impingement from injured ligamentous fibers
MR low signal intensity, consistent with fibrous tissue
DDX lesions in Hoffa’s fat pad:
Cyclops lesion
Hoffa’s disease: traumatic and inflammatory changes occurring in the infrapatellar fat pad in young athletes  leads to fibrosis
Synovitis
Intra-articular loose body
Synovial osteochondromatosis
Solitary chondroma
Acromegaly

Case findings: 
ST prominence, tuft size is increased and spadelike
Heel pad thickening (> 23 mm may suggest acromegaly)
Enlargement of destruction of sella turcica
Secondary to pituitary adenoma

Onset of acromegaly is in the 3rd - 5t
Acromegaly

Case findings:
ST prominence, tuft size is increased and spadelike
Heel pad thickening (> 23 mm may suggest acromegaly)
Enlargement of destruction of sella turcica
Secondary to pituitary adenoma

Onset of acromegaly is in the 3rd - 5th decade
Gigantism: manifested by an increase in stature, when the syndrome occurs before epiphyseal fusion
Lipoma arborescens

Case findings:
Sagittal T1: hypertrophic synovial villi distended with fat and a large joint effusion
Sagittal T2: frondlike mass and large joint effusion in the suprapatellar recess
Intra-articular fatty tumour of unknown cause
MC in knee
May arise de novo or develop in DJD, RA, or trauma
Focal deposits of fat are observed beneath a swollen synovial membrane
Adamantinoma

Case findings:
Expansile osteolytic lesion with patchy sclerosis in the tibia
MC localized in the middle third of the tibia or other tubular bone
Multilocular, slightly expansile osteolytic lesion, sometimes with reactive bone sclerosis and small satellite radiolucent foci

DDX:
Fibrous dysplasia
Osteofibrous dysplasia (ossifying fibroma): cannot differentiate from adamantinoma
Pyknodysostosis

DDX of diffuse osteosclerosis and acro-osteolysis:
Hyperparathyroidism
Pyknodysostosis

Skull:
Hypoplasia of mandible
Widening of cranial sutures
AR, short stature, normal mentation
Wormian bones

Wormian bones

Intrasutural bones, MC lambdoid suture

DDX (PORKCHOPS)
Pyknodysostosis
Osteogenesis imperfecta
Healing rickets
Menke’s kinky hair syndrome: defective intestinal copper absorption
Cleidocranial dysostosis
Hypothyroidism (cretinism), hypophosphatasia
Otopalatodigital syndrome: an osteochondrodysplasia characterized by typical facies, hearing defects, and digits resembling those of a tree frog in both hands and feet
Primary acro-osteolysis (Hadju-Cheney) / pachydermoperiostosis (idiopathic, familial hypertrophic osteoarthropathy)
Down’s syndrome
Osteopetrosis (marble bone disease, Albers-Schonberg)

Types: congenital AR lethal, tarda AD benign

Symmetrical generalized dense bones (lack of cortical and medullary differentiation)
Bone-in-bone appearance in spine and long bones
Sandwich verte
Osteopetrosis (marble bone disease, Albers-Schonberg)

Types: congenital AR lethal, tarda AD benign

Symmetrical generalized dense bones (lack of cortical and medullary differentiation)
Bone-in-bone appearance in spine and long bones
Sandwich vertebra sign: increased density at vertebral end plates
Diffuse vertebral body sclerosis
Increased density at skull base and calvaria

DDX:
Engelmann’s: affects only diaphysis of tubular bone (in contrast, osteopetrosis affects the entire bone)
Sandwich vertebra sign: increased density at end plates
Chondroblastoma

DDX end of bone lesion (epiphysis, apophysis):
Chondroblastoma
ABC
GCT
Infection
EG
Low-grade chondrosarcoma
Glomus tumor

Case findings:
Scalloped lytic defect with sclerotic border

Benign vascular tumor
Clinical triad: sensitivity to cold, localized tenderness, severe intermittent pain

DDX tuft cystic lesion:
Subungual glomus tumor (enhances)
Epithelial inclusion cyst
Thorn granuloma (enhances)
Tumoral calcinosis

Small calcified nodules progress to large multilobular calcific deposits in periarticular tissues
MC on extensor surfaces
Single joint involvement
Tumoral calcinosis

Small calcified nodules progress to large multilobular calcific deposits in periarticular tissues
MC on extensor surfaces
Single joint involvement
Sarcoidosis

Lacelike lytic lesions in short tubular bone
Chondrosarcoma

XR:
Lucency in left sacrum with an abnormal soft tissue density containing calcified matrix overlying the left sacrum and ilium

CT:
Large mass surrounding and involving the left posterior ilium and sacrum
Cortical destruction of the posterior sacrum and ilium
ST tissue component of the mass invades the iliacus and gluteal muscles and contains multiple areas of calcification
DDX:
Chondrosarcoma
Osteosarcoma
Chordoma
Plasmacytoma

XR: lucent lesion with scalloping of the cortex and periosteal reaction
CT: define the cortex and visualize calcification of the cartilage matrix
MR: presurgical evaluation to visualize the extent of bone and soft tissue involvement
TB arthritis

Case findings:
XR: lobulated lucency of proximal ulna, demineralization of the distal humerus, and effusion
CT: erosions of the radial head, distal humerus and ulna with edema or cellulitis in the subcutaneous tissues posterior to the elbow
MR: correlate well with CT and demonstrate joint effusion with abnormal signal and bony destruction of the distal humerus and proximal radius with likely cellulitis in the posterior subcutaneous tissues
Chest CT (not shown): demonstrates LUL nodules

Uncommon, slowly progressive disease  MC monoarticular and involves weight bearing joints
Early changes: distention of joint capsule/effusion, soft tissue swelling, joint dislocation
Late changes: joint space destruction, erosion, osteopenia
Parosteal osteosarcoma

Case findings:
XR:
Exuberant, aggressive, disorganized periosteal reaction of the distal femur with increased sclerosis of the bone
CT:
Confirm a large mass with extensive bone formation, portions contiguous with the cortex of the femur
MR:
Large mass of mixed signal intensity that arises from and nearly encircles the distal femur
Greatest bulk of the mass projects posteriorly
Bone marrow involvement and cortical breakthrough near the lateral femoral condyle
Osteosarcoma: 2nd MC primary malignant bone tumor (after multiple myeloma)

May be secondary to:
Paget’s disease
Fibrous dysplasia
3-50 years after radiation
Dedifferentiated chondrosarcoma

Types:
Parosteal, periosteal
Conventional
Telangiectatic
Radiology:
Purely osteolytic (~30% of cases)
Purely osteoblastic (~45% of cases)
Mixture of both
Elevation of the periosteum (Codman triangle)
Extension of tumor through the periosteum may result in a sunburst appearance

MR: assess extent of intramedullary disease (medullary backgrowth)
Bone scan: evaluation for the presence of metastatic or multifocal disease
Multiple hereditary exostoses

Case findings:
Multiple large, irregular, calcified masses arising from distal femora and proximal tibia and fibula
Continuity of the medullary space and cortical surface of the masses into the underlying metaphysis
No sclerotic margin, orientation away from the adjacent joints, and the presence of cartilage caps are demonstrated
DDX single osteochondroma:
Osteoma
Periosteal chondroma
Juxtacortical myositis ossificans
Fibrous dysplasia
Chondrosarcoma
Parosteal osteosarcoma
Soft tissue osteosarcoma
Osteosarcoma

AP pelvis:
Calcified ST mass associated with the mid portion of the left ischium with mild bony irregularity of the ischium

CT pelvis:
Pathologic fracture through left acetabulum
Osteolytic defect of ischium and ileum at the hip joint
Soft tissue mass with calcification medial to acetabulum.

MR pelvis:
Heterogeneous mass in left acetabulum extending anteroinferiorly into the pubic ramus and posteriorly into the ischium
Extensive soft tissue component projecting medially and displacing the obturator internus muscle
heterogeneous enhancement of the bone
Peripheral enhancement is noted in the soft tissue mass suggesting a central necrotic component
MC males, 2nd – 3rd decades
DDX:
Ewing’s sarcoma

Classification by location:
Intramedullary or central
Intracortical
Surface
Periosteal
Parosteal
DDX solitary lucent epiphyseal lesion

Chondroblastoma 
Giant cell tumor
Aneurysmal bone cyst
Eosinophilic granuloma

Intraosseous ganglion
Geode 
Infection (TB)
PVNS (often multiple lucencies, erosions) 

Pigmented villonodular synovitis
DDX solitary lucent epiphyseal lesion

Chondroblastoma
Giant cell tumor
Aneurysmal bone cyst
Eosinophilic granuloma

Intraosseous ganglion
Geode
Infection (TB)
PVNS (often multiple lucencies, erosions)

Pigmented villonodular synovitis

Case findings:
XR:
Sharply marginated cortical lucency in proximal tibia

MRI:
Synovial proliferation with diffuse hemosiderin deposition (low T1 and T2) within the hypertrophied synovium
Bone erosion within the posterior aspect of the tibial plateau, just inferior to the tibial eminence
Fluid in the suprapatellar pouch
Types: 
Nodular form:
Focal proliferation of synovial tissue within any synovial-lined structure, and MC occurs in tendon sheaths and IP joints of the hands
Former variety is often referred to as tendon sheath xanthoma or giant cell tumor of a tendon sheath
Diffuse form:
Proliferation of synovial tissue in intraarticular synovial cavity of a joint
MC monoarticular, MC knee

Proliferating synovium causes pressure erosion of adjacent bone
MC monoarticular and LACKS periarticular osteopenia
DDX:
Synovial osteochondromatosis:
Synovial proliferation and the formation of cartilaginous or calcified loose bodies in synovial space
Non-calcified synovial osteochondromatosis can appear identical to PVNS
No hemosiderin deposition
Synovial sarcoma:
No hemosiderin deposition
Osteonecrosis

Case findings:
Extensive avascular necrosis involving left femoral head, neck and proximal shaft
Reactive left hip joint effusion
Right femoral head demonstrates a lesser degree of avascular necrosis than the left femoral head
Etiology (GASEPTIC):
Gaucher’s
Anemia
Steroids
Ethanol
Pancreatitis, pregnancy
Trauma
Idiopathic (LCP)
Caissons, collagen vascular disease
Perilunate dislocation

Diagnosis: dorsal perilunate dislocation with scapholunate disruption and no evidence of fracture

Case findings:
Volar tilt to the lunate
Capitate is dorsal to and overlaps the lunate
Proximal lunate articular surface remains aligned with the distal radius
Associated widening of the scapholunate joint
AP view:
Carpus is foreshortened with overlap of the proximal and distal rows
Triangular shaped lunate  indicates tilting of the lunate which could be associated with lunate or perilunate dislocation
Lateral view is needed to make the diagnosis

Perilunate dislocation
Capitate lies dorsal or volar to the lunate bone
Proximal articular surface of the lunate remains parallel to distal radius
Lunate dislocation
Proximal articular margin and central axis of the capitate remain aligned with distal radius
Lunate is almost invariably displaced volarly
Osteochondritis

Case findings:
Widening of the capitellum with decreased mineralization
Fragmentation and ST density with the radiocapitellar joint

MC children between the ages of 10-15 years  little league elbow

Little league elbow

Medial epicondyle avulsion
Delayed or accelerated growth of the medial epicondyle
Medial epicondylar apophysitis
Delayed closure of the medial epicondylar growth plate
Osteochondritis or OCD of the capitellum
Deformity of the radial head
Olecranon apophysitis

Panner’s disease

Involves capitellum of distal humerus
MC boys, 5-10 years old
Separated from osteochondritis by age, mechanism and no loose body formation
Full return of function whereas osteochondritis often leads to post-traumatic arthritis
Giant cell tumor

Osteolytic eccentric, epiphyseal extension from metaphyseal origin
Intermediate aggressiveness with poorly defined margins and no rim of sclerosis
MC about knee, 50% recurrence 
After irradiation: chance of malignant transformation
Giant cell tumor

Osteolytic eccentric, epiphyseal extension from metaphyseal origin
Intermediate aggressiveness with poorly defined margins and no rim of sclerosis
MC about knee, 50% recurrence
After irradiation: chance of malignant transformation into osteosarcoma or fibrosarcoma

DDX:
Giant cell tumor
Aneurysmal bone cyst
Chondroblastoma
LCH
Infection
Greater trochanter: apophysis, an epiphyseal equivalent
Osteopoikilosis

Case findings:
Multiple, ill-defined, sclerotic lesions throughout the pelvis  with the appearance of multiple bone islands
Type of osteosclerotic dysplasia

Features:
Multiple well-defined, rounded, small, homogenous sclerotic foci
Symmetric distribution, predilection for epiphyseal and metaphyseal segments of tubular bone
Appear as multiple bone islands
DDX multiple sclerotic lesions:
Multiple bone islands
Osteopoikilosis
Osteoblastic metastases
Mastocytosis
Tuberous sclerosis

Mastocytosis

Proliferation of fibroblasts and granulomatous tissue in the marrow replacing normal marrow
Osteopenia, expansion and ballooning of the medullary cavity, thin cortices
Remaining trabecula is thickened
Sclerosis takes place with bone repair

Small bowel:
Wall thickening and barium segmentation
Small nodular filling defects in a segmental pattern
Fibrolipomatous hamartoma (neural fibrolipoma)

Case findings:
Axial proton-density MR image of the wrist: heterogenous mass within the carpal tunnel
Mass contains fat, displaces the flexor tendons and causes bowing of the flexor retinaculum 

Tumo
Fibrolipomatous hamartoma (neural fibrolipoma)

Case findings:
Axial proton-density MR image of the wrist: heterogenous mass within the carpal tunnel
Mass contains fat, displaces the flexor tendons and causes bowing of the flexor retinaculum

Tumor of fatty and fibrous tissue
MC involves median nerve in the carpal tunnel, LC tibial nerve
Associated with macrodystrophia lipomatosa
Gradual infiltration of nerves by fibrofatty tissue (MC median nerve)
Fibrous dysplasia

Case findings:
XR: large expansile lesion of 12th posterior rib

DDX:
Fibrous dysplasia
Plasmacytoma
Metastatic disease
Chondrosarcoma
Radiolucent expansile medullary lesion (but may replace both cancellous and cortical bone)
Ground glass: due to dysplastic microtrabeculae
Well-defined sclerotic margins, endosteal scalloping

Either monostotic (80%) or polyostotic
McCune-Albright syndrome:
Polyostotic fibrous dysplasia
Cafe au lait spots
Precocious puberty
Dermatomyositis

Linear and confluent calcifications in soft tissues (at pressure points in the extremities, axillae, hands and inguinal regions)
Lacy, reticular subcutaneous calcium deposit encasing the trunk

Fibrosis leads to contractures and deformities of the trunk
Hemophilic arthropathy

Hemorrhage produces synovitis (pannus formation)

Features:
Overgrowth of epiphysis
Widening of intercondylar notch (knee)
Hemosiderin deposition
Joint effusion

DDX:
Juvenile RA
Lipohemarthrosis

Mixture of fat and blood in a joint cavity following trauma 
Presence of a fat-fluid level is nearly diagnostic of a fracture, even when that fracture is radiographically occult 

Posterior dislocation of the right hip with blood an
Lipohemarthrosis

Mixture of fat and blood in a joint cavity following trauma
Presence of a fat-fluid level is nearly diagnostic of a fracture, even when that fracture is radiographically occult

Posterior dislocation of the right hip with blood and fat filling the acetabular fossa White arrow indicates fat layering upon blood (black arrow)

Lipohemarthrosis of glenohumeral joint: globular focus of fat layering upon a small amount of blood
Onchronosis (alkaptonuria)

Spondylitis and arthritis of large joints (knees, shoulders, hips)
Deposition in cartilage  synovial thickening
Spine:
Degenerative disc disease 
Resembles ankylosis spondylitis
Disc space calcification 

Pathognomoni
Onchronosis (alkaptonuria)

Spondylitis and arthritis of large joints (knees, shoulders, hips)
Deposition in cartilage  synovial thickening
Spine:
Degenerative disc disease
Resembles ankylosis spondylitis
Disc space calcification

Pathognomonic: seen in younger patient
Universal disc calcification
DJD of root joints (hips and shoulders)

LS and Pelvis:
Severe osteoporosis
Widespread discal calcifications with disc space loss Sclerosis of SI joints bilaterally
Ossification in acetabular labra of the hips
Tarsal coalition

Diagnosis: subtalar coalition (talocalcaneal)
Case findings:
Lateral ankle:
C sign: C-shaped line formed by medial outline of talar dome and inferior outline of sustentaculum tali
CT ankle:
Bony bridge between talar dome and suste
Tarsal coalition

Diagnosis: subtalar coalition (talocalcaneal)
Case findings:
Lateral ankle:
C sign: C-shaped line formed by medial outline of talar dome and inferior outline of sustentaculum tali
CT ankle:
Bony bridge between talar dome and sustentaculum tali

Types: cartilage, fibrous tissue, osseous
MC calcaneonavicular, LC talocalcaneal
Diagnosis: calcaneonavicular coalition

Anteater nose sign: enlargement of the anterosuperior portion of the calcaneus (arrow)
Diagnosis: talocalcaneal coalitition

Osseous excrescence or "beak" protruding from anterior talus (arrow)
Multiple hereditary exostoses (MHE)

Multiple bilateral and symmetrical osteochondromas
MRI may be used to assess cartilaginous cap
Development of pain attributable to an exostosis is worrisome from sarcomatous degeneration

Complications:
Fracture
Vascular injury
Neurologic compromise
Bursa formation
Malignant transformation
Jaccoud’s arthritis

Case findings:
Radial deviation at radiocarpal joint
Ulnar deviation at the MCP joints
Capsular erosions at several metacarpal heads

Deforming nonerosive arthropathy that may appear after repeated attacks of arthritis in patients with rheumatic fever
Asymptomatic, reversible joint deformities
Osteoarthritis

Features:
Joint space narrowing
Subchondral sclerosis
Marginal osteophyte formation
Subchondral cysts

Hands
Not due to mechanical stress
MC involves 1st MCP of thumb, DIP

Secondary degenerative arthritis

Atypical location: CPPD (knee)
Atypical appearance: marked DJD of one hip (RA, AVN)
Atypical age

Types:
Trauma, infection
AVN
RA, CPPD
Hemophilia
Gout

Asymmetric, monoarticular
MC involves 1st MTP
Olecranon bursitis common
Tophi rarely calcify

Features:
Juxta-articular erosions (overhanging edges)
No joint space narrowing (JSN a late finding)
Soft tissue swelling
No osteoporosis
Rheumatoid arthritis

Features:
Bilaterally symmetrical
Proximal joints: MCP, PIP, ulnar styloid
Periarticular demineralization

May lead to secondary DJD:
Marked narrowing of joint space
Intact articular cartilage
Little or no sclerosis

RA f
Rheumatoid arthritis

Features:
Bilaterally symmetrical
Proximal joints: MCP, PIP, ulnar styloid
Periarticular demineralization

May lead to secondary DJD:
Marked narrowing of joint space
Intact articular cartilage
Little or no sclerosis

RA foot: 5th MTP early (MC)
RA of hips: marked JSN, little sclerosis
Systemic lupus erythematosus

Subluxation without erosions
DDX: SLE, Jaccoud's arthropathy
AVN: intrinsically or secondary to steroids
Psoriatic arthritis

Case findings:
Hand: 
Periostitis (arrows)
STS of 3rd digit
Erosions at margin of DIP joint 

Fingers:
Marginal and central erosions (arrows) 
Intra-articular ankylosis
Flexion contractures at DIP joints 

MC involves DIP
Psoriatic arthritis

Case findings:
Hand:
Periostitis (arrows)
STS of 3rd digit
Erosions at margin of DIP joint

Fingers:
Marginal and central erosions (arrows)
Intra-articular ankylosis
Flexion contractures at DIP joints

MC involves DIP (hands > feet)
Acro-osteolysis (pencil-in-cup deformity)
Soft tissue swelling (sausage digit)
No osteoporosis
Asymmetric SI involvement (like IBD, TB)
Spine: non-marginal syndesmophytes
Case findings: diffuse fusiform soft-tissue swelling of entire 3rd digit

Sausage digit: fusiform soft-tissue swelling involving an entire, single digit

Psoriatic sacroiliitis

Asymmetric SI joint (DDX: IBD, TB)
Non-marginal syndesmophytes

Ivory phalanx sign

Sclerosis of an entire phalanx (MC great toe)
Result of bony proliferation as an exaggerated healing response to injury

Seen in seronegative spondyloarthropathy (e.g. psoriatic arthritis)
Scleroderma

Case findings:
Hands: acroosteolysis and flexion contractures
Pelvis: extensive soft tissue calcifications

MC affects DIP, IP, and surrounding soft tissues areas of the hand
Acroosteolysis at distal phlangeal tufts secondary to pressure from surrounding sclerotic soft tissues
Soft tissue subcutaneous and periarticular calcifications
Soft tissue atrophy and thickening
Tendon sheath fibrosis can cause contracture deformities

Preferential involvement of 1st CMC
Osteolysis of trapezium and 1st metacarpal base
1st metacarpal subluxation
Intra-articular calcifications
Charcot arthropathy

Features:
Fragementation
Soft tissue swelling
Joint destruction
Sclerosis
Osteophytosis

Joint involvement:
Shoulder (syrinx)
Hips (tertiary syphilis, diabetes)
Feet (diabetes)
Multiple bone infarcts from sickle cell disease
Multiple bone infarcts from sickle cell disease
Avascular necrosis
Pigmented villonodular synovitis (PVNS)

Proliferative disorder affecting synovium of joints, bursae, and tendons
Dense hemorrhagic effusion
Hemosiderin deposition

Well-defined erosions 
Nodular synovial masses in a juxta-articular distribution (l
Pigmented villonodular synovitis (PVNS)

Proliferative disorder affecting synovium of joints, bursae, and tendons
Dense hemorrhagic effusion
Hemosiderin deposition

Well-defined erosions
Nodular synovial masses in a juxta-articular distribution (low T1 and variable T2)

NOT seen: osteophytic response
Acetabular protrusio

Diagnosis: Paget’s
Medial wall of acetabulum projects medial to ilioischial line (> 6 mm women, > 3 mm men)

Primary protrusio (Otto pelvis): 
Affects middle-aged women 
Familial protrusion of the acetabulum, bilateral

Seco
Acetabular protrusio

Diagnosis: Paget’s
Medial wall of acetabulum projects medial to ilioischial line (> 6 mm women, > 3 mm men)

Primary protrusio (Otto pelvis):
Affects middle-aged women
Familial protrusion of the acetabulum, bilateral

Secondary:
Paget’s disease
Rheumatoid arthritis, ankylosing spondylitis, septic arthritis
Osteoarthritis, osteomalacia
Sickle cell anemia
Neoplasm, trauma, irradiation
RA, CPPD:
Axial migration of femoral head
Symmetric loss of joint space

OA:
Migration of femoral head is superior or medial
Consequence of more focal destruction of cartilage

Primary acetabular protrusio (Otto pelvis)
Idiopathic protrusio acetabuli bilaterally, secondary arthritic changes are seen
Chondrocalcinosis

CPPD (calcium pyrophosphate dihydrate) deposition leads to
Distinctive gout-like pattern of arthritis (pseudogout)
Structural joint damage (pyrophosphate arthropathy)
Calcification of articular cartilage (knee, hip, shoulder, TFCC, symphysis)
Patello-femoral compartment involvement

Pseudogout arthropathy (similar to OA):
Medial joint space narrowing
Subchondral sclerosis
Osteophyte formation
Chondrocalcinosis
Chondrocalcinosis:
Calcification of hyaline (articular) cartilage or fibrocartilage (menisci)

DDX (“HOGWASH”) of chondrocalcinosis:
Hemochromatosis
Ochronosis
Gout
Wilson’s
Acromegaly
MC pseudogout (CPPD deposition)
Hyperparathyroidism
Fibrous dysplasia

Radiolucent expansile medullary lesion (but may replace both cancellous and cortical bone)
Ground glass: due to dysplastic microtrabeculae
Well-defined sclerotic margins, endosteal scalloping

Either monostotic (80%) or polyostotic
McCune-Albright syndrome:
Polyostotic fibrous dysplasia
Cafe au lait spots
Precocious puberty
Non-ossifying fibroma
Reiter’s syndrome

Clinical triad: urethritis, arthritis, conjunctivitis
Periostitis at tendinous insertions (whiskering)
DDX: DISH, AS
Osteoporosis
DDX: RA
Prepatellar bursitis
Osteochondritis dessicans