Medical Immunology Dickinson Lecture 9 Mhc Complex

Front 1

MHC complexes are found on what cells?

Back 1

antigen presenting cells

Front 2

MHC Class ___ contains 2 beta microglobulins and 2 alphas

Back 2

II

Front 3

MHC Class __ contains 1 beta and 3 alpha microglobulins

Back 3

I

Front 4

MHC Class ___ molecule binds 7-15 length peptides. MHC Class __ binds 10-30 length acid peptides

Back 4

I; II

Front 5

CD8 binds the ___ domain of the MHC Class ___ molecule

Back 5

alpha3; I

Front 6

CD4 binds the _____ domain of the MHC Class ___ molecule

Back 6

beta2; II

Front 7

exogenous antigen is presented in MHC Class __. Endogenous antigen is presented in MHC Class ___

Back 7

II; I

Front 8

____ genes are required for the transport of endogenous antigen into the ER for loading onto MHC

Back 8

TAP

Front 9

where are peptides that bind to MHC Class II molecules generated?

Back 9

in acidified endocytic vessels

Front 10

What is cross-presentation?

Back 10

when extracellular antigens are taken up and presented in the context of MHC Class I molecules in order to mount a cytotoxic CD8 T-cell response (major role in HIV)

Front 11

What prevents MHC class II molecules from binding to peptides while in the ER?

Back 11

invariant chain

Front 12

Most cells express MHC Class __ molecules

Back 12

I

Front 13

__ and ___ cells are the main expressors of MHC Class II molecules

Back 13

B; dendritic

Front 14

What are the only non-hematopoetic cells to express MHC Class II molecules?

Back 14

thymic epithelium

Front 15

MHC Class ___ deficiency is known as 'bare lymphocyte syndrome', resulting in severe combined immunodeficiency

Back 15

II

Front 16

what are HLA-A, HLA-B and HLA-C?

Back 16

the most polymorphic MHC Class I Human Leukocyte Antigens

Front 17

What are the most polymorphic Class II Human MHC's?

Back 17

HLA-DP, HLA-DQ and HLA-DR

Front 18

What is the advantage of being more polymorphic and polygenic for MHC?

Back 18

recognize and be able to fight off more antigens

Front 19

what does 'co-recognition' mean in the context of TCR's?

Back 19

TCR's recognize a complex of BOTH MHC and the peptide it holds

Front 20

What effect does polymorphism have of tissue transplants?

Back 20

high polymorphism increases the likelihood of transplant rejection

Front 21

What is the tissue most sensitive to MHC disparity?

Back 21

bone marrow

Front 22

What occurs in Graft vs. Host disease

Back 22

transplanted T-cells begin attacking the recipient's tissues