Inhibitors Of Dna/rna Synthesis

Front 1

Antibiotics that inhibit DNA/RNA synthesis are considered (bacteriostatic/ bacteriocidal)

Back 1

bacteriocidal

Front 2

Fluorquinolones- Mechanism?

Back 2

Inhibit DNA/RNA synthesis by either inhibiting DNA gyrase or topisomerase

Front 3

Norfloxacin is a member of which type of antibiotic?

Back 3

Fluoroquinolones (DNA/RNA synthesis inhibitors)

Front 4

Ciprofloxacin is a member of which type of antibiotic ?

Back 4

Fluoroquinolones (DNA/RNA synthesis inhibitors)

Front 5

which drug can be used to treat anthrax?

Back 5

Cipro

Front 6

What must be remembered when prescribing cipro?

Back 6

Limited use among children, adolescents, and pregnant women due to possible cartilage damage and tendon rupture

Front 7

Sulfonamides- mechanism?

Back 7

folic acid synthesis inhibitor

Front 8

why is inhibiting folic acid synthesis and effective bacteriocidal effect?

Back 8

Folic acid needed for synthesis of DNA/RNA
-bacteria synthesize their own folic acid (cannot utliize what they obtain from the environment)

Front 9

Give an example of competitive inhibition

Back 9

Sulfonamides compete with PABA (p-aminobenzoic acid) at the first step of folic acid synthesis

Front 10

What was the first "magic bullet" ? What is the mechanism?

Back 10

Sulfonamides
inhibit folic acid synthesis

Front 11

what is the spectrum for sulfonamides? Give two examples

Back 11

Broad spectrum (usually used for UTI, conjunctivitis, and toxoplasmosis)

sulfamethoxazole
silver sulfadiazine

Front 12

What is a major counseling point for sulfonamides?

Back 12

Drink LOTS of water!!! can crystalize in the kidney

May have cross-sensitivty to sunscreens with PABA

Front 13

What are some adverse effects of sulfonamides?

Back 13

skin rashes, especially in combo with trimethoprim (bactrim)

Front 14

Mechanism of trimethoprim?

Back 14

competition inhibition- inhibits the synthesis of tetrahydrophilic acid (a later step in folic acid synthesis)

RARELY used alone

Front 15

Give an example of two synergistic medications

Back 15

Sulfamethoxazole and trimethoprim

Front 16

What adverse effects would you expect for bactrim?

Back 16

skin rashes (esp in HIV)