First Aid Gi Pharm

Front 1

4 H2 blockers

Back 1

cimetidine, ranitidine, famotidine, nizatidine

Front 2

MOA of H2 blockers

Back 2

reversibly block H2 receptors which causes decreased H+ secretion by gastric parietal cells

Front 3

cimetidine toxicities

Back 3

P450 inhibitor; antiandrogenic; crosses BBB (confusion, HAs, dizziness) and placenta

Hint 3

None

Front 4

2 proton pump inhibitors

Back 4

omeprazole, lansoprazole

Front 5

MOA of PPIs

Back 5

irreversibly bind H+/K+ ATPase in gastric parietal cells

Front 6

MOA of bismuth, sucralfate

Back 6

bind to ulcer base and provide physical protection, allow bicarb secretion to reestablish pH gradient in mucous layer

Front 7

triple tx of H. pylori?

Back 7

metronidazole + bismuth + amoxicilin/tetracycline

Front 8

MOA of misoprostol

Back 8

PGE1 analog, that increases production and secretion of gastric mucous barrier and decreases acid production

Front 9

toxicity/contraindications for misoprostol

Back 9

(PGE1 analog) diarrhea, not for women of childbearing potential

Front 10

which 2 muscarinic antagonists used for treatment of peptic ulcer?

Back 10

pirenzepine, propantheline

Front 11

toxicities of pirenzepine and propantheline?

Back 11

tachycardia, dry mouth, difficulty focusing eyes

Front 12

overuse of aluminum hydroxide can cause what problems?

Back 12

(antacid) constipation, hypophosphatemia, proximal mm weakness, osteodystrophy, seizures

Front 13

overuse of magnesium hydroxide can cause what problems?

Back 13

(antacid) diarrhea, hyporeflexia, hypotension, cardiac arrest

Front 14

overuse of calcium carbonate can cause what problems?

Back 14

(antacid)hypercalcemia, rebound acid increase

Front 15

MOA of infliximab

Back 15

monoclonal TNF-alpha ab

Front 16

clinical use of infliximab

Back 16

Crohn's dz, rheumatoid arthritis

Front 17

infliximab toxicity

Back 17

respiratory infection, fever, hypotension

Front 18

MOA sulfasalazine

Back 18

combo antibacterial (sulfapyridine) and anti-inflammatory (mesalamine); activated by colonic bacteria

Front 19

clinical use of sulfasalazine

Back 19

UC, Crohn's disease

Front 20

toxicity of sulfasalazine (5)

Back 20

malaise, nausea, sulfonamide toxicity, reversible oligospermia

Front 21

MOA of ondansetron

Back 21

5-HT3 antagonist (powerful central acting anti emetic)

Front 22

clinical use of ondansetron

Back 22

antiemetic; to control vomiting post-op and in pts undergoing chemotherapy

Front 23

toxicity of ondansetron

Back 23

headache, constipation

Front 24

MOA of cisapride

Back 24

acts thru serotoni R to increase Ach release at myenteric plexus; increases esophageal tone; increases gastric and duodenal contracitlity and improves transit time (prokinetic)

Front 25

Clinical use of cisapride

Back 25

prokinetic (on GIT) but no longer used because of serious interactions with erythromycin, ketoconazole, nefazodone, fluconazole (-->torsades de pointes!)

Front 26

MOA of metoclopramide

Back 26

D2 R antagonist; increases resting tone, contractility, LES tone, motility but does not increase transit time thru colon. (pro-kinetic)

Front 27

clinical use of metoclopramide

Back 27

diabetic and post-surgery gastroparesis

Front 28

toxicity of metoclopramide

Back 28

(D2 R antag). Increased Parkinsonian effects; restlessness, drowsiness, fatigue, depression, nausea, constipation.

Front 29

drug interactions of metoclopramide

Back 29

digoxin and diabetic agents

Front 30

contraindications for metoclopramide?

Back 30

(D2 R antag) pts with small bowel obstruction