Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
30 Cards in this Set
- Front
- Back
- 3rd side (hint)
|
4 H2 blockers
|
cimetidine, ranitidine, famotidine, nizatidine
|
|
|
|
MOA of H2 blockers
|
reversibly block H2 receptors which causes decreased H+ secretion by gastric parietal cells
|
|
|
|
cimetidine toxicities
|
P450 inhibitor; antiandrogenic; crosses BBB (confusion, HAs, dizziness) and placenta
|
None
|
|
|
2 proton pump inhibitors
|
omeprazole, lansoprazole
|
|
|
|
MOA of PPIs
|
irreversibly bind H+/K+ ATPase in gastric parietal cells
|
|
|
|
MOA of bismuth, sucralfate
|
bind to ulcer base and provide physical protection, allow bicarb secretion to reestablish pH gradient in mucous layer
|
|
|
|
triple tx of H. pylori?
|
metronidazole + bismuth + amoxicilin/tetracycline
|
|
|
|
MOA of misoprostol
|
PGE1 analog, that increases production and secretion of gastric mucous barrier and decreases acid production
|
|
|
|
toxicity/contraindications for misoprostol
|
(PGE1 analog) diarrhea, not for women of childbearing potential
|
|
|
|
which 2 muscarinic antagonists used for treatment of peptic ulcer?
|
pirenzepine, propantheline
|
|
|
|
toxicities of pirenzepine and propantheline?
|
tachycardia, dry mouth, difficulty focusing eyes
|
|
|
|
overuse of aluminum hydroxide can cause what problems?
|
(antacid) constipation, hypophosphatemia, proximal mm weakness, osteodystrophy, seizures
|
|
|
|
overuse of magnesium hydroxide can cause what problems?
|
(antacid) diarrhea, hyporeflexia, hypotension, cardiac arrest
|
|
|
|
overuse of calcium carbonate can cause what problems?
|
(antacid)hypercalcemia, rebound acid increase
|
|
|
|
MOA of infliximab
|
monoclonal TNF-alpha ab
|
|
|
|
clinical use of infliximab
|
Crohn's dz, rheumatoid arthritis
|
|
|
|
infliximab toxicity
|
respiratory infection, fever, hypotension
|
|
|
|
MOA sulfasalazine
|
combo antibacterial (sulfapyridine) and anti-inflammatory (mesalamine); activated by colonic bacteria
|
|
|
|
clinical use of sulfasalazine
|
UC, Crohn's disease
|
|
|
|
toxicity of sulfasalazine (5)
|
malaise, nausea, sulfonamide toxicity, reversible oligospermia
|
|
|
|
MOA of ondansetron
|
5-HT3 antagonist (powerful central acting anti emetic)
|
|
|
|
clinical use of ondansetron
|
antiemetic; to control vomiting post-op and in pts undergoing chemotherapy
|
|
|
|
toxicity of ondansetron
|
headache, constipation
|
|
|
|
MOA of cisapride
|
acts thru serotoni R to increase Ach release at myenteric plexus; increases esophageal tone; increases gastric and duodenal contracitlity and improves transit time (prokinetic)
|
|
|
|
Clinical use of cisapride
|
prokinetic (on GIT) but no longer used because of serious interactions with erythromycin, ketoconazole, nefazodone, fluconazole (-->torsades de pointes!)
|
|
|
|
MOA of metoclopramide
|
D2 R antagonist; increases resting tone, contractility, LES tone, motility but does not increase transit time thru colon. (pro-kinetic)
|
|
|
|
clinical use of metoclopramide
|
diabetic and post-surgery gastroparesis
|
|
|
|
toxicity of metoclopramide
|
(D2 R antag). Increased Parkinsonian effects; restlessness, drowsiness, fatigue, depression, nausea, constipation.
|
|
|
|
drug interactions of metoclopramide
|
digoxin and diabetic agents
|
|
|
|
contraindications for metoclopramide?
|
(D2 R antag) pts with small bowel obstruction
|
|
