Barker Hypothesis And Pre-Eclampsia

Front 1

What is the Barker hypothesis?

Back 1

Babies that are too small are predisposed to adult diseases

Front 2

What can placental insufficency lead to...?

Back 2

Vascular problems, malnutrition, Inc incidence of CVD in later life

Pre-eclampsia and IUGR

Front 3

Pre-eclampsia

Nutshell?

Back 3

Disorder or late pregnancy.

Left untreated may progress to eclampsia, life threatening condition characterised by convulsions

5-10% pregnancies

Front 4

Diagnosis of Pre-eclampsia

Back 4

Diagnosed by high BP (>140/90 mmHg) and proteinuria (>300mg/24h)

20 weeks and after in normotensive patients

Front 5

What causes this disease then?

Back 5

Abnormal trophoblast invasion in to the maternal tissue

As a result...spiral arteries do not undergo full physiological change and hence blood flow to placenta is reduced

Front 6

Back 6

Front 7

Diagram outlining barker hypothesis

Back 7

Front 8

What are the consequences to a baby malnourished in the first trimester?

Back 8

Down regulation of growth
Reduced birth weight
Small body
Raised Blood pressure

Die by Haemorrhagic stroke

Front 9

What are the consequences to a baby malnourished in the second trimester?

Back 9

Insulin resistance or deficiency
Reduced birth weight
Thin body
Hypertension, NIDDM

Death by CHD

Front 10

What are the consequences to a baby malnourished in the third trimester?

Back 10

Brain growth good, trunk no
GH resistance or deficiency
Normal birth weight
Short body
Hypertension, NIDDM, Raised fibronogen etc

Death by thrombotic stroke, CHD

Front 11

Three methods to explain poor lung function in adult life

Back 11

Dec in utero growth=Dec ling growth= Inc Resp infections = Dec child lung function = Inc decline in Adult lung function
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Poor childhood SES = Poor education = Poor adult SES = Air pollution, poor diet, smoking etc = Inc decline in Adult lung function
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Childhood chest illness = Poor education = low SES = as above