Skeletal muscle wasting or skeletal muscle atrophy is common symptoms in a variety of chronic diseases such as acquired immune deficiency syndrome (AIDS), Chronic Obstructive Pulmonary Disease (COPD), muscle denervation, muscle immobility, Diabetes, and cancer. In the cancer cachexia, there is skeletal muscle wasting phenomenon. Skeletal muscle wasting may cause respiratory system dysfunction and reduce the patient’s mobility and quality of life. The prevalence of cancer cachexia is estimated to affect 50–80% of patients with cancer and accounts for up to 20% of deaths. One of the mechanisms of the skeletal muscle wasting is ubiquitin-proteasome system (UPS), involved in the degradation of proteins leads to skeletal muscle wasting. Causes in
