The midwifery team should be well informed to be able to answer questions in a supportive role. Incidence rates of ICP vary with geography and ethnicity, from less than 1% in North America and up to 4% in Chili . (11:141, 12:1-2). The cause is not well understood but it is believed to have some genetic and environmental factors. (9:178, 12:3) The genetic link is supported by the increased occurrence rates within families, ethnic and geographic variations and the high risk of reoccurrence, (60 to 70%), in subsequent pregnancies. (12:3, 13:280) Non-genetic or environmental factors include low vitamin D levels, low selenium levels, hepatitis C, multiple gestations, maternal age over 35, seasonal factors (as incidence rates increase in the winter months), and a potential hormonal component. (9:178, 11:149, 17:329) Maternal implications include varying severities of pruritus, increased risk of postpartum hemorrhage due to fat excretion from steatorrhea affecting (due to malabsorption of vitamin K absorption), long term risks of hepatobiliary cancer and autoimmune-mediated and cardiovascular diseases, and risk of reoccurrence. (9:183, 17:331) The fetal implications include increased rates of spontaneous and iatrogenic preterm labour, fetal asphyxia events, meconium stained amniotic fluid, and stillbirth. (11:142, 17:329) The severity of fetal implications is related to the level of maternal serum bile acid levels, with “severe” levels classified as >40 μmol/L. (9:183, 17:329,
The midwifery team should be well informed to be able to answer questions in a supportive role. Incidence rates of ICP vary with geography and ethnicity, from less than 1% in North America and up to 4% in Chili . (11:141, 12:1-2). The cause is not well understood but it is believed to have some genetic and environmental factors. (9:178, 12:3) The genetic link is supported by the increased occurrence rates within families, ethnic and geographic variations and the high risk of reoccurrence, (60 to 70%), in subsequent pregnancies. (12:3, 13:280) Non-genetic or environmental factors include low vitamin D levels, low selenium levels, hepatitis C, multiple gestations, maternal age over 35, seasonal factors (as incidence rates increase in the winter months), and a potential hormonal component. (9:178, 11:149, 17:329) Maternal implications include varying severities of pruritus, increased risk of postpartum hemorrhage due to fat excretion from steatorrhea affecting (due to malabsorption of vitamin K absorption), long term risks of hepatobiliary cancer and autoimmune-mediated and cardiovascular diseases, and risk of reoccurrence. (9:183, 17:331) The fetal implications include increased rates of spontaneous and iatrogenic preterm labour, fetal asphyxia events, meconium stained amniotic fluid, and stillbirth. (11:142, 17:329) The severity of fetal implications is related to the level of maternal serum bile acid levels, with “severe” levels classified as >40 μmol/L. (9:183, 17:329,