The INK4A cell has a role in the G1 cell cycle which is held by the G1 cyclin-dependent kinases (CDKs) 4/6), in this manner, allowing access into the S-phase of the Cell Cycle.
When the INK4A cell and the CDKs don’t bind, it can lead to a hyperphosphorylation, mitosis regulator, failure and that causes the cell cycle to just keep going without control.
The melanoma mutation affects the cell checkpoints during the G1 and G2 Interphase steps. This causes the cell to lose control of division, and mutate, which causes cancers. In this case it would start in the skin.
Since they are cancer cells and do not have limits, they grow and travel to other parts of the body out of control. …show more content…
This cell is most commonly mutated with this disease. Most of these diseases include a mutation in a gene called BRAF which can make proteins that can cause cells to divide quicker. Figure 3 shows what makes up your skin.
Dermatologists can diagnose Melanoma by doing a physical skin test and checking moles or other weird spots
Sometimes a Dermoscope is used to get a better look
The dermatologists can see pigments in the cell or feel lymph nodes or glands
If weird spots are spotted, small parts can be taken for a biopsy (which is needed for