How Different Drugs Work in the Body at a Molecular Level
First, it is important to understand the drug kinetics so as to understand how a drug works. Typically, this is how the drug is introduced to the body, how it reaches the point of action, and how it is removed from the body. The most important stage is absorption, and it highlights how the drug is introduced into the body. It includes intravenous administration, subcutaneous injection, intramuscular injection, oral administration, and rectal administration. Each of these ways determines how the drug is absorbed into the body. Distribution is the next stage, and it deals with how a drug reaches different organs in the body. The metabolism stage, the majority of which takes place in the …show more content…
The particular ones in question are secreted during the body’s immune system response to bacteria and other pathogens in injuries. In cases of injuries, prostaglandins exist around the wound, and this leads to pain and inflammation. During bacterial infections, however, they are produced by the hypothalamus, resulting in an increase in body temperature. The therapeutic effect of aspirin stems from suppressing the secretion of prostaglandins.
As observed, aspirin inhibits the secretion of prostaglandins by inhibiting the enzyme that facilitates the biochemical reactions responsible for the production of prostaglandins. The reason the enzyme (which is a catalyst) is necessary lies in the molecular structure of arachidonic acid, which synthesizes prostaglandins. Arachidonic acid is a carboxylic acid that, as shown below, contains a chain of 20 carbon atoms in its molecule. …show more content…
Mostly, it is because the exact working of aspirin was not established until the early 1990s when the two types of COX 1 and COX 2 enzymes were distinguished from each other (Zarghi and Arfaei). There are already some advancements of aspirin through the creation of super aspirins. Examples of these include selective COX 2 inhibitors, which as the name suggests, only target the COX 2 enzyme. By blocking the COX 1 enzyme, the traditional aspirin prevents the secretion of the prostaglandin responsible for regulating the acid production in the stomach and the mucous lining that prevents the acid from corroding the stomach walls. Expectedly, some people suffer from stomach upsets and ulcers after taking aspirin. The anticoagulant effect of aspirin from blocking COX 1, while it is important in reducing the risk of recurring strokes, is problematic when it comes to closing wounds. Even so, selective COX 2 inhibitors work well to bypass these
First, it is important to understand the drug kinetics so as to understand how a drug works. Typically, this is how the drug is introduced to the body, how it reaches the point of action, and how it is removed from the body. The most important stage is absorption, and it highlights how the drug is introduced into the body. It includes intravenous administration, subcutaneous injection, intramuscular injection, oral administration, and rectal administration. Each of these ways determines how the drug is absorbed into the body. Distribution is the next stage, and it deals with how a drug reaches different organs in the body. The metabolism stage, the majority of which takes place in the …show more content…
The particular ones in question are secreted during the body’s immune system response to bacteria and other pathogens in injuries. In cases of injuries, prostaglandins exist around the wound, and this leads to pain and inflammation. During bacterial infections, however, they are produced by the hypothalamus, resulting in an increase in body temperature. The therapeutic effect of aspirin stems from suppressing the secretion of prostaglandins.
As observed, aspirin inhibits the secretion of prostaglandins by inhibiting the enzyme that facilitates the biochemical reactions responsible for the production of prostaglandins. The reason the enzyme (which is a catalyst) is necessary lies in the molecular structure of arachidonic acid, which synthesizes prostaglandins. Arachidonic acid is a carboxylic acid that, as shown below, contains a chain of 20 carbon atoms in its molecule. …show more content…
Mostly, it is because the exact working of aspirin was not established until the early 1990s when the two types of COX 1 and COX 2 enzymes were distinguished from each other (Zarghi and Arfaei). There are already some advancements of aspirin through the creation of super aspirins. Examples of these include selective COX 2 inhibitors, which as the name suggests, only target the COX 2 enzyme. By blocking the COX 1 enzyme, the traditional aspirin prevents the secretion of the prostaglandin responsible for regulating the acid production in the stomach and the mucous lining that prevents the acid from corroding the stomach walls. Expectedly, some people suffer from stomach upsets and ulcers after taking aspirin. The anticoagulant effect of aspirin from blocking COX 1, while it is important in reducing the risk of recurring strokes, is problematic when it comes to closing wounds. Even so, selective COX 2 inhibitors work well to bypass these