The kidneys are considered to be very important body organs found in organisms such as humans and animals. These two bean shaped pairs of organs play a big role especially in the human body by extracting waste from blood, help balance body fluids, and most of all form urine. These organs are a major help to numerous of important functions throughout the body. In “Kidney stone mystery solved: Why some people are more prone to develop kidney stones” a recent article by Science Daily, explains a new recent research of a common condition that affects an estimation 1 million Americans each year, who experience excruciating pain that affects both male and females (ScienceDaily). This new research is profound with evidence that explains the reason
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There is a genetic variation found in a gene called claudin-14 which has been found to the linkage of about 65 percent of patients to have a risk of getting kidney stones. Throughout the new research, scientist have seen the ways this gene’s activity gets altered and develops kidney stones. “Claudin-14 gene is not active in the kidney but the expression is dampened by two snippets of RNA, a sister molecule of DNA that essentially is silence the gene” (ScienceDaily). One of the researchers mentions the way claudin-14 works as a filtering system by allowing minerals in the blood to pass through the kidneys and absorbed again back into the bloodstream which they are sent to cells and help function out everyday lives. When bad dieting such as consuming high amounts of salt and calcium without large quantities of water, the small RNA molecules allow an increase in the gene claudin-14 activity which prevents calcium from re-entering the blood through passages called tight junctions found in cells that aid the lining of the kidney and the separation of blood from urine (SienceDaily). A formation of large amounts of calcium goes to the urine leading to formation of stones being developed in the kidneys or bladder if calcium does not have a way back into the bloodstream. This later results to an intense and excruciating amount of pain in the bladder, ureter or urethra when large stones get stuck and block the flow of
There is a genetic variation found in a gene called claudin-14 which has been found to the linkage of about 65 percent of patients to have a risk of getting kidney stones. Throughout the new research, scientist have seen the ways this gene’s activity gets altered and develops kidney stones. “Claudin-14 gene is not active in the kidney but the expression is dampened by two snippets of RNA, a sister molecule of DNA that essentially is silence the gene” (ScienceDaily). One of the researchers mentions the way claudin-14 works as a filtering system by allowing minerals in the blood to pass through the kidneys and absorbed again back into the bloodstream which they are sent to cells and help function out everyday lives. When bad dieting such as consuming high amounts of salt and calcium without large quantities of water, the small RNA molecules allow an increase in the gene claudin-14 activity which prevents calcium from re-entering the blood through passages called tight junctions found in cells that aid the lining of the kidney and the separation of blood from urine (SienceDaily). A formation of large amounts of calcium goes to the urine leading to formation of stones being developed in the kidneys or bladder if calcium does not have a way back into the bloodstream. This later results to an intense and excruciating amount of pain in the bladder, ureter or urethra when large stones get stuck and block the flow of