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18 Cards in this Set
- Front
- Back
Cholinergic (M) Agonists
GENERAL INFO |
- Stimulating muscarinic receptors
-mimics actions of acetylcholine -also known as parasympathomimetics -responses related to PNS tone: Heart Exocrine glands Smooth muscle Eye |
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Bethanechol
Trade type |
Urecholine©
Cholinergic (M) Agonists |
|
Bethanechol
MOA |
-reversible activation of muscarinic receptors
-no effect on nicotinic receptors |
|
Bethanechol
PHARMACOLOGY |
-heart: bradycardia
-exocrine glands: sweating, salivation, bronchial secretions, gastric acid secretion -smooth muscle: bronchoconstriction, ↑GI tone & motility, bladder emptying, vasodilation -eye: miosis, accommodation for near vision |
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Bethanechol
USES |
-urinary infections
|
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Bethanechol
Adverse effects |
-SLUDGE:
salivation, lacrimation, urination, defecation, GI upset, Emesis -hypotension -bradycardia |
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Bethanechol
CONTRAINDICATIONS |
-hypotension
-heart failure -gastric ulcers, intestinal obstruction, bowel surgery -UTI -asthma -hyperthyroidism |
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Cholinergic Antagonist
ACTIONS |
-competitive blockade of muscarinic receptors
-blocks action of acetylcholine -parasympatholytics -responses related to lack of PNS tone * heart *exocrine glands * smooth muscle * eye * CNS |
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Atropine
type |
Cholinergic Antagonists
|
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Atropine
MOA |
-Competitive blockade of muscarinic receptors
-Nicotinic blockade can occur at high doses |
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Atropine
PHARMACOLOGY |
-heart-↑HR
-exocrine glands: ↓secretion salivary, bronchiole, sweat glands. ↓acid secretion stomach. -smooth muscle: bronchodilation, & ↓urinary & GI tone. No effects on vessels. -eye: mydriasis & accomm for far vision -CNS- excitation, delirium & hallucinations |
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Atropine
INDICATIONS |
Pre-Intubation
bradycardia Cholinergic Agonist OD Eye disorders Intestinal Hypertonicity & Hypermotility Peptic Ulcer Asthma Biliary Colic Organophosphate poisoning |
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Atropine
Adverse Effects |
-dry mouth
-blurred vision & photophobia -elevation of intraocular pressure -urinary retention -constipation -anhidrosis & hyperthermia -tachycardia -thickened bronchiole secretions |
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Atropine
Drug Interactions |
-Ipratropium bromide (Atrovent)
-Benztropine (Cogentin) -Diphenhydramine (Benadryl) -Dimenhydrinate (Gravol) -Anti-psychotics (TCA’s) |
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Atropine
Dose |
PEDS PRE INTUBATION: 0.02mg/kg IV, min 0.1mg, max 0.5mg
CARDIAC ARREST: 1mg IVP q3-5m (max 0.04 mg/kg or 3 mg total) GO WITH LOWEST BRADYCARDIA/AV BLOCK: 0.5-1mg IVP q3-5m (max 0.04 mg/kg or 3 mg total) ORGANOPHOSPHATE: 2mg IVP q5 until reversal of SLUDGE VS ↑ |
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Hyoscine Butulbromide
Trade type |
Buscopan©
Cholinergic Antagonists |
|
Hyoscine Butulbromide
MOA |
- relaxes smooth muscles of GI, biliary, & urinary tracts
- cannot cross BBB -classified: Anti-Spasmodic |
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Hyoscine Butulbromide
INDICATIONS |
- GI/Bladder spasm
-Biliary Colic |