Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
16 Cards in this Set
- Front
- Back
List 5 ways to mediate immunopathology
|
1. antibody
2. cell 3. cytokine 4. complement 5. nitrous oxide |
|
Which type of CD4 cells drive T cell mediated (CD8) response? What cytokines are used?
|
TH1 CD4 cells mediate CD8 response. The TH1's secrete TNF-a IL-2 INF-g
|
|
Which type of CD4 cells drive B cell mediated response? What cytokines are secreted?
|
TH2 cells drive B cell mediated response. TH2 cells secrete IL-4, 5, 6, 10,
|
|
What are T DTH cells?
|
Delayed type hypersensitivity. effector cells that secrete cytokines that inhibiton infection and attract other effector cells
|
|
What are CD25+ fox p3+ T reg cells?
|
T cells that participate in antigen specific supprression of immune response, failure to act enhances immune pathology
|
|
List 5 ways that antibodies can block viruses
|
1. Block attachment
2. Block endocytosis 3. Block uncoating 4. neutralization after replication starts 5. Aggregation- opsonization and phagocytosis |
|
How does complement antiviral
|
MAC kills infected (and non infected cells by drift)
|
|
describe how antibodies can contribute to immunopathology
|
-non neutralizing Abs create immune complexes
-example Dengue fever=> hemorrhagic fever, if reinfected with a different strain, Abs bind but dont' kill leads to lots of Fc which triggers Macs to release tons of TNFa leading to hypovolemic shock and death |
|
What mediates a type I hypersensitivity
|
IgE and mast cells
|
|
What mediates a type II hypersensitivity
|
antibody and complement
|
|
What mediates a type III hypersensitivity
|
Immune complexes, involves complement or NK cells as effectors
|
|
What mediates a type IV hypersensitivity
|
CD4+ t cells
|
|
What are two ways that viruses can elicit a type 1 hypersensitivity
|
1. Skew immune response, RSV has G protein that pushes TH2 response and generation of IgE
2. Change secretion- virus infected cells release eotaxin which is a chemoattractant for mast cells |
|
Which two viruses can lead to a type II hypersensitivity
|
1. AIDS-vasculitis
2. HBV hepatitis- glomerular nephritis |
|
Name a virus that can cause a type IV hypersensitivity
|
HSV -keratitis leading to blindness
Measles-rash |
|
Which immune cells are a major factor in HSV induced blindness
|
CD4+ delayed type hypersensitive
|