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12 Cards in this Set
- Front
- Back
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Normal GFR |
90-120 ml/min/1.73m2 125ml/min or 180L/day |
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Filtration membrane |
Glomerular capillary endothelium Basement membrane Visceral layer of Bowman's capsule |
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Glomerular filtration rate |
Total quantity of filtrate formed in all the nephrons of both the kidneys in the given unit of time. |
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Filtration fraction |
Portion of the renal plasma that becomes the filtrate Ff=GFR/RPF x 100 Normally - 15-20% |
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Pressures determining filtration |
1. Glomerular capillary pressure 2. Colloidal osmotic pressure in the glomeruli 3. Hydrostatic pressure in the Bowman's capsule |
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Glomerular capillary pressure |
About 60 mmHg (45-70 mmHg) Highest capillary pressure in the body. |
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Colloidal osmotic pressure |
Pressure exerted by the plasma proteins in the glomeruli. About 25 mmHg |
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Hydrostatic pressure in Bowman's capsule (Capsular hydrostatic pressure) |
Pressure exerted by the filtrate in Bowman's capsule. About 15 mmHg. |
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Starling's hypothesis |
The net filtration across the capillary membrane is proportional to the hydrostatic pressure difference across the membrane minus the oncotic pressure difference. |
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Filtration coefficient |
The GFR per mm Hg of net filtration pressure. FC= GFR/net filtration pressure |
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Factors increasing GFR by vasodilation |
Atrial natriuretic peptide Brain natriuretic peptide cAMP Dopamine NO PGE2 |
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Factors decreasing GFR by vasoconstriction |
Angiotensin II Endothelin Noradrenaline Platelet activating factor Platelet derived growth factor PGF2 |
