The Pathology Of Infectious Diseases

Front 1

5 Spectra of inflammatory responses to infection.

Back 1

1. Suppurative
2. Mononucleus/granulomatous
3. Cytopathic-proliferative
4. Necrotizing
5. Chronic to scarring

Front 2

Characteristics of suppurative

Back 2

1. Vascular permeability
2. Neutrophils
3. GPC/GNR = PUS PUS PUS

Front 3

Examples of suppurative

Back 3

1. Abscesses
2. Lobar pneumonia

Front 4

Synonyms for suppurative

Back 4

acute, purulent, pyogenic, neutrophilic

Front 5

Definition of granuloma

Back 5

Collection of macrophages (other inflammatory cells not required)

Front 6

Typical granulomatous responses

Back 6

Fungi, intracellular bacteria/parasites, helminths, spirochetes, or random foreign material.

Front 7

Features of granulomas

Back 7

Caseating necrosis, lymphoid infiltrates, inclusions

Front 8

Histo evidence of a granulamatous infxn

Back 8

Langhans multinucleated cell

Front 9

Definition of a cytopathic-cytoproliferative inflammation

Back 9

Cell rxns to virus mediated damage to host cells (inflammatory response not required)

Front 10

Examples of a cytopathic-proliferative inflammation

Back 10

1. Cellular inclusions
2. Multinucleation
3. Cell necrosis
4. Dysplasia

Front 11

HIsto Example of an intranuclear inclusion

Back 11

Ground glass inclusions in Herpes infections

Front 12

Histo example of multinucleation

Back 12

Esophageal herpes simplex infected squamous cell

Front 13

Histo example of cell necrosis

Back 13

Herpes liver infxn (cells appear black)

Front 14

Histo appearance of HPV infected squamous mucosa

Back 14

nuclear enlargement, koilocytic change. Nucleus appears in a weird bubble.

Front 15

Severe HPV infxns induce. . .

Back 15

squamous cell proliferation

Front 16

Characteristics of necrotizing inflammation

Back 16

Infectious agent produces toxins, the end result is severe damage and cell death.

Front 17

Two types of necrotic lesions

Back 17

1. Ischemic - blood loss
2. Liquefactive - cell is digested

Front 18

Two examples of necrotizing inflammation

Back 18

Clos perf. gangrene, Group A strep fasciitis

Front 19

Characteristics of chronic inflammation

Back 19

No more neutrophils, but mononuclear, lymphocytes, fibroblast proliferation

Front 20

Culture of infectious agents

Back 20

Specific, but out of clinical or histological context

Front 21

Routine histopathology and 3 types.

Back 21

Direct contextual view, less specific. Histochemical stains, immunoperoxidase rxns, nucleic acid probes

Front 22

Staph aureus

Back 22

pyogenic skin infxns, lesions (boils, carbuncles, impetigo, scalded skin syndrome)

Front 23

Furuncle

Back 23

Abscesses which rupture the overlying skin

Front 24

Carbuncle

Back 24

Deeper abscesses, inflammation runs laterally beneath skin and fascia, multiple adjacent skin sinuses

Front 25

Paronychia

Back 25

Abscesses at nail bed

Front 26

Felon

Back 26

Abscesses at palmar fingertip

Front 27

Full list of staph aureus infections

Back 27

TSST, focal skin infxn, wound infxn, impetigo, endocarditis, pulmonary infections, food poisoning

Front 28

Streptococcus skin infections

Back 28

1. Localized acute (carbuncle)
2. Invasive (cellulitis)
3. TSST
4. ARF and glomerulonephritis

Front 29

Impetigo

Back 29

Neutrophil inflammation of the epidermis

Front 30

Erysipelas

Back 30

inflammation of the dermis

Front 31

Cellulitis

Back 31

Acute inflammation of the soft tissue (adipose)

Front 32

Fasciitis

Back 32

Acute inflammation of deeper fascial plane

Front 33

Diseases of clostridium perfringens

Back 33

Anaerobic cellulitis, septicemia, myonecrosis

Front 34

Key toxin of clostridium perfringens

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Alpha toxin: degrades lecithinase destroying RBCs, platelets, skeletal muscle.

Front 35

Sulfur granule

Back 35

A clump of actinomyces organisms ringed by neutrophils

Front 36

Non-spore-forming anaerobic infxns

Back 36

Bacteroides, Prevotella, Fusobacterium, and Actinomyces

Front 37

Common causes of non-spore-forming anaerobic infections

Back 37

Intra-abdominal abscesses secondary to surgery, visceral perf, septic abortion, salpingitis

Front 38

Histo appearance of a neutrophilic abscess

Back 38

discoloration, foul odor, fibrous or fibrinous wall

Front 39

Who gets opportunistic infections

Back 39

1. HIV
2. Cancer
3. Transplant
4. SYSTEMIC STEROID TREATMENT

Front 40

OI - CMV Histo

Back 40

"Owl's eye" cells, focal necrosis, chronic inflammation -- endo and epi