Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
17 Cards in this Set
- Front
- Back
|
3 types of pigment |
Artifact Exogenous Endogenous |
|
|
Define pigment |
Coloring agents that are deposited into cells and tissue |
|
|
List examples of artifact pigments |
Fixative artifacts: Formalin Mercury Chromium |
|
|
Examples of exogenous pigments |
Tattoos Lead Carbon Asbestos fibers (Outside of the body) |
|
|
Provide examples of endogenous pigments |
Hematogenous (blood-hemoglobin, iron, bile) Nonhematogenous (lipidic-lipofuchsin wear and tear) (nonlipidic-melanin pigment from hair skin eyes) |
|
|
How would you demonstrate melanin? |
Bleach procedure |
|
|
Discuss the melanin bleach procedure |
0.25% potassium permanganate 2% oxalic Acid |
|
|
Describe the principles of hematogenous pigments |
Life span ~120 days Destroyed by hemolysis in the spleen (red pulp) |
|
|
Iron is stored in _______ for future use in the ____ & ____. |
Protein complex Spleen & bone marrow |
|
|
Bile is broken down into _____ & _____. |
Biliverdin Bilirubin |
|
|
Causes of increased bile include: |
Abnormal flow increase RBC hemolysis Jaundice |
|
|
Neuroendocrine cells containing granules include : |
Chromaffin cells Paneth cells Argentaffin cells Agyrophilic cells |
|
|
Chromaffin cell characteristics include |
Secrete hormones Granules are best preserved by chromate fix (ex. Orth) |
|
|
Paneth cells characteristics include |
Important for gut immunity Destroyed by acetic acid |
|
|
Argentaffin cells characteristics include |
Found in gut Can bind AND reduce silver Destroyed by alcoholic fixatives Also found in melanin, carcinoid tumors |
|
|
Agyrophilic cells characteristics include |
Bonds silver ONLY found in neurosecretory tumors |
|
|
Other substances include |
Urates (crystals in gout) Minerals (copper calcium iron) |
