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10 Cards in this Set
- Front
- Back
What effect does CCK have on the gallbadder?
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causes contraction of the gallbladder and relaxation of the sphincter of Oddi (bile is ejected in spurts)
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What stimulates CCK release?
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small peptides and fatty acids in duodenum (bile is needed to emulsify and absorb lipids)
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What two substances cause contraction of the gallbladder?
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ACh and CCK
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How are bile acids recirculated to the liver?
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Na-bile acid cotransporter in terminal ileum delivers bile to portal blood
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Why are bile acids not recirculated until they reach the terminal ileum?
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so that they are present for maximal r/a of lipids throughout the upper small intestine
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What effect would ileal resection have on stool?
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causes steatorrhea
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What is the advantage of the liver converting bile acids into bile salts?
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bile salts are much more soluble (pK b/t 1-4) in duodenum (pK b/t 3-5); in duod bile salts will be in ionized form
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What is the role of the gall bladder epithelial cells?
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absorb water and ions in an isosmotic fashion, thus concentrating the organic components
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What is the negative feedback regulation of bile acid synthesis?
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bile salts feed back and inhibit rate-limiting enzyme in bile acid biosynthetic pathway in liver
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What are the regulatory effects when bile salts are recirculated to the liver?
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inhibits bile acid synthesis, and stimulates biliary s/c (choleretic effect)
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