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18 Cards in this Set
- Front
- Back
Transports T3 and T4 on plasma?
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Thyroxine binding globulin(TBG), thyroxine binding prealbumin(T4) and albumin(T3 and T4)
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Action of TSH on thyroid?
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Increases trapping of iodide, increase retrieval of Thyroglobulin, Increase fusion of lysosomes, increases T3 and T4 release
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Ratio of T4:T3
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4:1 released
20:1 in blood b/c T4 is more protein bound and has longer half life |
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Alterations in drug transport?
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Renal disease: decrease in plasma proteins, Pregnancy increases estrogen: increase plasma proteins, Testosterone and glucocorticoids: decrease TBG levels
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Levothyroxine?
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T4, for hypothyroidism, several weaks to reach steady state, monitor TSH and T4
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Liothyronine?
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T3 for hypothyroidism
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Liotrix?
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T4:T3 4:1
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Drug interaction of Levothyroxine?
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increased effects of warfarin, TCA, Amiodarone, devrease efficacy by oral contraceptives, rifampicin
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Possible hyperthyroid treatment?
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Surgery, Radioactive Iodide, Drugs
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Methimazole
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Thioureylene(thioamides) for hyperthyroid
MOA: Inhibits iodination and coupling CI: pregnancy SE: agranulocytosis, granulocytopenia, skin rash |
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Propylthiouracil(PTU)?
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Thioureylene(thioamides) for hyperthyroid
MOA: Inhibits iodination and coupling and blocks T4 to T3 PTU is better for pregnancy SE: agranulocytosis, granulocytopenia, skin rash |
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Iodide?
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For hyperthyroididm,used with thyroid storm, preoperative treatment
MOA: decreases iodination and hormone release |
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Radioactive Iodide?
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Orally administered, CI: younger than 35 or childbearing age, overtreatment causes hypothyroidism
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Beta-blockers(propranolol) effects with hyperparathyroidism?
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Treats adverse effects on heart and blocks T4 to T3
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Inhibits Deiodination(T4 to T3)
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PTU, Beta-blockers, corticosteroids
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Symptomes of Thyroid storm?
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Heat intolerance, diaphoresis, hyperpyrexia, tachycardia, high output heart failure, arrhythmias....
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Causes of Thyrroid storm?
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Infection, surgery, trauma, readioactive iodide treatment, pregnancy, drugs, TH ingestion, diabetic ketoacidosis
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Treatment for Thyroid storm?
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Antipyretics, hydrocortisone(block T4-T3), Beta-blockers, PTU, high doses of iodide, treat heart failure
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