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17 Cards in this Set
- Front
- Back
What is Pharmacokinetics?
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action or effect of body on drug(what the body does on the drugs as opposed to what the drug does on the body)
relates to absorption,distribution,metabolism and excretion in the body(ADME) |
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What is Pharmacodynamics?
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action or effect of drug on body
-how drugs interact with their targets |
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Give definitions of a “drug”
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Any substance that brings about a change in biologic function through its chemical actions
A molecule that interacts with specific molecular components (i.e. receptor) of an organism to cause biochemical and physiologic changes Any substance received by a biological system that is not received for normal nutritive purposes |
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Drug target
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Tissue element with which drugs interact to produce a change in a biological system
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T or F.A drug may stabilize a receptor conformation that either augments or diminishes a cellular effect.
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True.i.e.Drugs modulate intrinsic physiological functions
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Agonist
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Bind receptors to mimic stimulatory effects of endogenous signaling molecules
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Antagonist
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Bind receptors to prevent binding of (and activation by) agonists; exhibit no activity
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Give examples of some drugs which do not interact with specific targets.
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Antacids-binds to protons
Osmotic agent |
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List the types of drug targets.
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1)Ion channels(Ligand-gated
Voltage-gated 2nd messenger-gated) 2)G protein-coupled receptors (GPCRs), or 7 transmembrane receptors (7TMRs) 3)Transmembrane receptors with enzymatic cytosolic domains Kinases Phosphatases Guanylyl Cyclases) 4)Receptors with enzymatic activity (e.gHER2 Receptors) |
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factors affecting drug-receptor interaction
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Receptor(e.g a.acid conformation)
Drug(structure-activity relationship) Environment(e.g PH) |
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most rapid receptor system?
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Ion channels
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True or False.Almost all receptor sytems contain enzymatic activity.
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True
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Discuss chemical factors(Chemical force/bond) contributing to drug-receptor interaction
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Hydrophobic
Van der Waals Hydrogen bonding Ionic bonding Covalent bonding |
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Characterstics of Ion channel drug receptor systems
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classified as ligand gated(depending on the ligand)
Voltage gated(depending on the voltage) or Second messenger gated -May undergo cycle of activation, open, closed, channel inactivation (refractory period in which channel cannot be activated) |
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Characterstics of GPCR drug receptor systems
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2nd messenger generation to amplify signal
Can have various allosteric sites for ligand binding |
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drug target that would take the longest to produce an effect
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Steroids
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example of a non protein drug target
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DNA's
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