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50 Cards in this Set
- Front
- Back
What are types of solid oral dosage forms? (3) |
1. Capsules 2. Powders 3. Tablets |
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What are some advantages for solid oral dosage forms for patients? (4) |
1. Non-invasive 2. Easy to take 3. Portable 4. Palatable |
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What are some disadvantages for solid oral dosage forms for patients? (2) |
1. Some drugs cause GI irritation 2. Big tablets can be hard to swallow |
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What are some advantages for solid oral dosage forms for manufacture? (4) |
1. Easy to make/ well established methods 2. Accurate dosing 3. Drug stability 4. Easy to pack, ship, and store |
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What are some disadvantages for solid oral dosage forms for manufacture? (2)
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1. Some drugs poorly soluble in aqueous setting
2. Some drugs have poor bioavailability |
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What are characteristics of a good tablet formation? (6) |
1. Stable 2. Accurate dosing 3. Consistent performance and pharmacokinetics 4. Easy to pack, ship, and store 5. Palatable 6 Pharmaceutically elegant |
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Define: excipients |
Pharmacologically inactive substances added to the API to improve or modify:
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Define: diluents |
Substances used to dilute or increase bulk volume of tablets for ease of handling. |
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What are characteristics of a good diluent? (7) |
1. Chemically inert 2. Hydrophilic/ water soluble 3. Palatable 4. Non-hygroscopic 5. Cheap 6. Compactible 7. Biocompatible |
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Define: binders |
A glue/ substance that helps granules and tablets compress into a stable tablet. |
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Define: disintegrants
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Substances used to help with tablet fragmentation upon ingestion. |
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MOA of disintegrants? (2) |
1. Help with water uptake to wet drug particles 2. Swelling of disintegrants causes tablet rupture |
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Define: lubricants |
Added to ensure tablet formation and ejection can occur without friction, to prevent capping, fragmentation, and scratches.
They are typically hydrophobic. |
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Define: glidants |
Used to improve flow of powder or granules. Sufficient flow is needed for high speed mass manufacturing. |
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Define: colorants |
Used for pharmaceutical elegants |
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What do you call a dog with no legs? |
It doesn't matter, it won't come. |
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Define: Flavouring |
Used to enhance palatability |
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Acacia |
Binder |
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Calcium carbonate |
Diluent |
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Calcium phosphate |
Diluent |
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Carnauba wax |
Binder |
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Cellulose |
Diluent Disintegrant |
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Citric acid |
Flavourant |
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Colloidal silicon dioxide/ colloidal silicon |
Glidant |
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Confectioner's (Icing) sugar |
Flavourant |
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Crosscarmelose |
Disintegrant |
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Crosspovidone |
Disintegrant |
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D&C Blue No. 2 |
Colorant |
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D&C Red No. 7 |
Colorant |
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D&C Yellow No. 6 |
Colorant |
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Gelatin |
Binder |
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If there's H2O on the inside of a fire hydrant, what's on the outside? |
K9P |
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Glucose |
Diluent |
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Hydroxypropylmethyl cellulose |
Binder |
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Lactose |
Diluent |
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Paraffin |
Lubricant |
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Magnesium stereate |
Lubricant Glidant |
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Mannitol |
Diluent |
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Microcrystalline cellulose |
Binder |
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Polyethylene Glycol (PEG) |
Binder Lubricant |
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Polyvinylpyrrilidone (PVP) |
Binder |
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Sodium lauryl sulfate |
Lubricant |
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Sodium starch glycolate |
Disintegrant |
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Sodium stearyl fumarate |
Lubricant |
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Sorbitol |
Diluent |
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Starch |
Binder Disintegrant |
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Stearic acid |
Lubricant |
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Sucrose |
Diluent Binder |
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Talc |
Glidant |
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Tapioca starch |
Binder |