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14 Cards in this Set
- Front
- Back
Blisters or bullae can arise due to several different causes, however, all of these causes are linked by what primary dysfunction?
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A weakening of localized areas within the skin layers causes fluid to accumulate between tissue layers.
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What are some of the ways that blisters can manifest?
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Blistering may occur as a secondary event associated with (1)viral or (2)bacterial infections of the skin (e.g. herpes simplex) and impetigo, or with local injury of the skin (e.g. burns, ischemia and dermatitis).
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Genodermatoses assocatiead with blisters are typically manifested in?
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Neonates, whereas autoimmune blistering disorders are acquired and usually expressed later in life.
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What is a vesicle? Is it different from a blister?
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A vesicle is a fluid-filled cavity or elevation smaller than or equal to 0.5 cm, whereas a bulla (blister) measures larger than 0.5 cm. The fluid in the cavity exerts equal pressure in all directions to give rise to a spherical shape. Vesicles tend to rupture easily and may be noted as an erosion or white thin plaque
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Where is cleavage in tense bullae commonly located?
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Cleavage in tense bullae are commonly located at the dermal-epidermal junction (DEJ).
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What type of blisters are usually the result of mechanical fragility, autoimmunity or genetic alteration of a component of the basement membrane zone?
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Sub-epidermal blisters.
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How are blisters formed?
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Blisters are formed as a result of a breakdown of tissue integrity and fluid accumulation in a specific compartment of the skin (i.e. subcorneal, suprabasilar, DEJ, or upper dermis).
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What does the presence of blisters in many patients signify?
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The presence of blisters in many patients is secondary to another subcutaneous disease.
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Local hypoxia secondary to decreased cutaneous blood flow can produce what?
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Blisters.
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In which epidermal compartments can blisters arise?
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Blisters can arise in the epidermis (limited by the stratum corneum on the outside and the basal cell layer on the inside); the DEJ or lamina lucida (limited by the cell surface of basal keratinocytes and the lamina densa); and the dermis (tissue located below the lamina densa).
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The kertainocyte system plays a role in the pathogenesis of what?
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Blister formation in lesions in the epidermal and DEJ compartments.
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What provides the melanin pigment?
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A network of melanocytes closely interacting with the keratinocyte cell system producing the melanin pigment, which is important in filtering out harmful environment UV radiation.
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What is the role of Langerhan Cells?
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Langerhan Cells compose a network of antigen-presenting cells involved in immunologic mechanisms.
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Friction blisters occur as a result of what?
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Friction blisters occur as a result of mid-epidermal necrosis.
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