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28 Cards in this Set
- Front
- Back
Nitrogen mustards
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Alkylating agents
Non-cell phase specific Mechlorethamine Cyclophosphamide (parent compound has no activity) Ifosfamide |
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Nitrosureas
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Alkylating agents
Non-cell phase specific Lipophilic (cross BBB) and renally eliminiated Carmustine (BCNU) Lomustine (CCNU) |
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Platinum analogues
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Alkylating agents
Non-cell phase specific Cisplatin Carboplatin Oxaliplatin |
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Folate antagonists
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Antimetabolites
S-phase specific Methotrexate Pemetrexed |
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Purine analogues
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Antimetabolites
S-phase specific Mercaptopurine Fludarabine Cladribine |
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Pyrimidine analogues
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Antimetabolites
S-phase specific Flourouracil (5-FU) Cytarabine (ara-C) Capecitabine - metabolized to 5-FU |
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Vinca alkaloids
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Antimicrotubule
M-phase specific - disassemble microtubules Vincristine Vinblastine Vinorelbine |
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Taxanes
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Antimicrotubule
M-phase specific - assemble and freeze microtubules Paclitaxel Docetaxel |
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Topo-I inhibitors
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S-phase specific
Irinotecan (CPT-11) Topotecan |
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Topo-II inhibitors
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S-phase specific
Etoposide (VP-16) teniposide |
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Anthracyclines
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Antitumor antibiotic
Non-cell phase specific Daunorubicin Doxorubicin Idarubicin Epirubicin Mitoxantrone |
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Other antitumor antibiotics
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Bleomycin
Dactinomycin Mitomycin |
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Which advanced malignancies can be cured with chemotherapy?
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Acute Lymphocytic Leukemia in children only
Acute myeloid leukemia Testicular Cancer Hodgkin's Disease Non-Hodgkin's Lymphoma Small cell lung cancer (limited stage) |
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Which malignancies can be treated with chemotherapy with "curative intent"?
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Breast cancer (Early stage)
Colorectal cancer (Advanced stages) Osteosarcoma Ovarian cancer |
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Which advanced cancers can have survival prolonged with chemotherapy?
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Breast Cancer
Bladder Cancer Multiple myeloma Head and neck cancer Pancreatic cancer Prostate cancer Non-small cell lung cancer |
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What is the combination regimen for NHL?
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CHOP - Cyclophosphamide, Hydroxy-daunarubicin, Oncovin (vincristine), Prednisone
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What is the combination regimen for Hodgkin's disease?
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ABVD - Adriamycin, Bleomycin, Vinblastine, Dacarbazine
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What is the combination regimen for breast cancer?
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CAF - Cyclophosphamide, Adriamycin, Fluorouracil
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What is the combination regimen for lung cancer?
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EP - Etoposide, Cisplatin
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What is the combination regimen for sarcoma?
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MAID - Mesna, Adriamycin, Ifosfamide, Dacarbazine
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Complete response
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No evidence of tumor
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Partial response
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At least 50% reduction in tumor size
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Disease progression
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Tumor progresses at original site or moves to another site.
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Stable disease
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Less than 25% change in tumor size (increase or decrease)
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Chemoprotectant: Mesna (Mesnex)
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indicated to decrease hemorrhagic cystitis caused by cyclophosphamide and iphosphamide. Mesna binds to the destructive metabolite
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Chemoprotectant: Dexrazoxane (Zinecard)
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cardioprotectant, protects from anthrocyclines. Free oxygen radicals damage the myocardium leading to heart failure; this drug scavanges the radicals.
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Chemoprotectant: Amifostine (Ethyol)
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triol to prevent nephroxicity w/ cysplatin. Can cause hypotension and severe N/V. Also used for radiation to reduce SE.
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Chemoprotectant: Leucovorin
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methotrexate inhibits dihydrofolate reductase, leading to myelosuppression & mucositis. Leucovorin rescues normal cells.
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