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35 Cards in this Set
- Front
- Back
The event that triggers puberty is
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adequate sun exposure
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The hypothalamic-pituitary axis is first known to function
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in utero
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What is the first endocrine event associated with secondary sexual maturation?
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Secretion of dehydroepiandrosterone DHEA by the adrenal glands
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What is the usual length of time from the first physical signs of secondary sexual maturation until sexual maturation is complete?
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4 years
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What is the expected sequence of secondary sexual development in girls?
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Thelarche, adrenarche, growth spurt, menarche, ovulation
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Which of the following is required for timely secondary sexual maturation?
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Sufficient body fat AND sleep AND light
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What is the baseline percentage of body fat needed to sustain female reproductive function?
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24%
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What is the earliest sign of delayed puberty in girls?
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Failure of breast budding by age 13
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When adrenarche occurs first, what is the expected interval to the onset of thelarche?
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6 to 9 months
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Which of the following may cause premature sexual development in adolescent girls?
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Ovarian neoplasm
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What is the most common genital tract cause of primary amenorrhea?
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Imperforate hymen
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Which of the following is a method for treating vaginal agenesis?
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Pressure dilation of the vaginal space
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What is the simple, definitive treatment for imperforate hymen?
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Hymenotomy
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What is the definitive chemical evidence of ovarian failure?
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Elevated follicle-stimulating hormone FSH
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Genetic information that regulates the rate of ovarian follicular atresia is located on
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the long arm of the X chromosome
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Genetic information that determines height and somatic characteristics is located on
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the short arm of the X chromosome
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Which of the following hormones must be replaced in girls with premature ovarian failure?
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Estradiol-17beta
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What is the risk of administering excessive estradiol-17beta (or other estrogens) in girls with pubertal failure?
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Short stature
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What is the risk of delaying administration of estradiol-17beta in girls with pubertal failure?
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Osteoporosis
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Alteration of the gonadotropin-releasing hormone pulse frequency in adolescent girls will result in
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no pituitary stimulation of the ovary
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What condition is associated with olfactory tract hypoplasia and failure of gonadotropin-releasing hormone secretion?
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Kallmann syndrome
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What condition is associated with failure to establish secondary sexual development, a webbed neck, and short stature?
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Turner syndrome
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During clinical evaluation, Kallmann syndrome can be recognized by
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olfactory challenge
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How could a patient with Kallmann syndrome be treated to help her conceive?
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Pulsatile administration of gonadotropin-releasing hormone
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In adolescents, what would be evidence of incomplete puberty that is caused by marijuana use?
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Suppressed gonadotropins (FSH & LH)
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What is the prognosis for adolescent girls who have delayed puberty or secondary amenorrhea resulting from participation in competitive athletics?
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Normal secondary sexual development can be anticipated
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Isosexual precocious puberty is defined as
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premature sexual maturation following the normal sequence
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What is the most common cause of inappropriate hormone secretion leading to precocious puberty in girls?
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Adrenal hyperplasia, 21-hydroxylase type
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What is the treatment of choice for children with isosexual precocious puberty?
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Gonadotropin-releasing hormone
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Isosexual precocious puberty generally results in
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short stature
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A woman with uterine and vaginal agenesis can have her own genetic child through
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ovum donation
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Premature ovarian failure is characterized by
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lower estrogen level, elevated gonadotropin levels
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In patietns with premature ovarian failure, the daily dose of conjugated estrogen to initiate secondary sexual maturation is
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0.3 mg
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In patients with premature ovarian failure, the daily dose of conjugated estrogen to induce menarch is
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1.25 mg
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In patients with premature ovarian failure, induction of cyclic bleeding is accomplished with the cyclic administration of
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progestin
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