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16 Cards in this Set
- Front
- Back
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What are considered lymphoid organs? |
Thymus, spleen, and lymph nodes |
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Which organ will lymphocyte encounter antigens? |
spleen and lymph nodes |
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What is an epitope. |
Small segment of an antigen that will elicit a specific response. |
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What are the two sections of adaptive immunity? |
Humoral and Cellular Immunity |
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Humoral immunity consists of... |
Antigens bind to MHC II proteins, recognized by T-cells and release antibodies. |
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Cellular Immunity consists of... |
Antigens bind to MHC I proteins, recognized by T-cells, produces NK cells, and directly kills infected host cells |
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FC region |
Interacts with host cells; aka effector cells, and amino acids are highly constant |
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FAB region |
Amino acids are highly variable; antigen binding region. |
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What are the steps to the Classical Complement Pathway |
C1 and Fc bin to form the Fc-C1 complex Fc-C1 complex reacts with C2 and C4 to make the C3b and C5 convertase. C5 convertase cleaves C5A and C5B - rest of pathway similar to Alternative Pathway |
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What links humoral and cell-mediated immunity? |
T-Cells |
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What are the two types of T-Cells |
T-Helper Cells and Cytotoxic T-Helper Cells |
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T-Helper Cells |
CD4+ TH1- responds to antigens from cancer cells - activate Cytotoxic T cells TH2- responds to antigens from blood stream - activates B cells to produce antibodies. |
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Cytotoxic T Cells |
CD8+ Destroy bacteria and infected host cells |
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What are T-Cell receptors |
antigen binding molecules present on the surface of T-Cells associated with CD3 proteins triggers t-cell proliferations |
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MHC I |
Nucleated cells Intracellular antigens |
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MHC II |
antigen presenting cell extracellular antigens8 |
