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9 Cards in this Set
- Front
- Back
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Name a example of what you can use for specific immunosuppresssion |
ALG (anti-lymphocytic globulin) Less damaging side effects |
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Whats the deviation/source if anti-lymphocytic globulin |
Large animals IgG Fraction is purified Large animals- more blood and serum |
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Antigen for ALG |
Human lymphoid cells Recently hunan foetal thymus(extremely potent) |
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Whats the short term target for ALG |
Small long-lived peripheral lymphocytes circulating between blood-lymph nodes Surveillance cells |
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Long term target for ALG |
Thymus dependent lymphocytes from the “cuffs” of lymphoid follicles depleted as they participate in recirculating pool |
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Mechanism of ALG |
Bind to surface of ag recognising T cell Cytotoxicity by serum complement |
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Cellular consequences of using ALG |
Specific destruction of T cells Consequently specific impairment of DTH and cellular immunity (T cell response) Antibody response is till intact(still have adaptive immune system) |
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Side effects of ALG |
side effects essentially due to foreign protein injectionI.e acquire anti-abs Serum sicjness ag-ab precipitates(can activate complement) (precipitates can clog the kidney-kidney damage) Lymphomas at injection site(quickly removed= abnormal cells that start to accumulate) |
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Limitations of use of ALG |
Because of the above ALG will eventually become ineffective Good for short term but after that the immune system starts to take over. Once ALG is injected you will get ALG antibodies since antibody response is still intact |
