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40 Cards in this Set
- Front
- Back
alternative pathway of complement
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pathway that is initiated by C3b, assoc. with innate immunity
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anaphylatoxin
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C3a, C4a, C5a. binding to their receptors on mast cells and basophils induces degranulations
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anaphylatoxin inhibitor
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a protein that inactivates the anaphylatoxins (C3a, C4a, C5a)
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Ba
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proteolytic fragment of Factor B following cleavage by Factor D
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Bb
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proteolytic fragment of Factor B following cleavage by Factor D, forms part of the C3 convertase AP
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C1 inhibitor protein (C1 INH)
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a protein that binds to C1 to prevent its activation, when unbound C1 leaves C4 and C2
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C1 through to C9
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proteins of the classical pathway
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C2b
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a weak kinin, and so can increase vascular permeability, it is a proteolytic fragment of C2
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C3 convertase (AP)
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C3bBb
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C3 convertase (CP)
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C4b2a
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C3 tickover
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term which refers to the spontaneous production of C3b which will activate AP of complement
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C3a, C4a, C5a
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anaphylatoxins - released from proteolytic cleavage of C3, C4, C5
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C3b
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proteolytic fragment of C3, an opsonin, activates alternative pathway, a component of both pathways
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C4bp
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regulatory protein, binds to C4b preventing its attachment to cells, promotes dissociation of C3 convertase
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C5 convertase (AP)
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C3bBbC3b
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C5 convertase (CP)
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C4b2a3b
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CD59
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membrane attack complex inhibitor, regulatory protein
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classical pathway of component
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pathway that is initiated by IgM or IgG immune complexes
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CR1
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complement receptor 1, receptor for C3b
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CR2
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complement receptor 2, receptor for C3bi
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CR3a/4a
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complement receptor 3a/4a, receptor for the anaphylatoxins C3a, C4a
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CR5a
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complement receptro C5a, receptor for the anaphylatoxin C5a
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decay accelerating factor (DAF)
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regulatory protein, prevents formation of, or causes dissociation of C3 convertases (binds C4b and C3b)
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Factor B
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component of the alternative pathway of complement, binds to deposited C3b
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Factor D
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enzyme that cleaves bound Factor B
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Factor H
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regulatory protein that binds C3b and so can prevent binding of Factor B to C3b, or cause the dissociation of C3bBb
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Factor I
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regulatory protein that requires one of several cofactors, cleaves soluble forms of C3b and of C4b
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glycosylphosphatidylinositol (GPI)
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molecule that serve to attach some proteins to the cell in leiu of a transmembrane domain
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hereditary angioedema (HAE)
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complement disorder caused by a genetic deficiency of C1 INH
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homologous restriction factor (HRF)
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MAC inhibitor, regulatory protein
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kallikrein
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formed during intrinsic coagulation pathway activation
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kininogen
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protein that is a substrate for kallikrein, bradykinin released
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membrane attack complexes (MAC)
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complex composed of C5b, 6, 7, 8, 9. complex inserts into the membrane to cause cell lysis
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Neisseria species
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bacterial species-MAC protein deficiencies (especially C8) results in recurrent infection with these bacteria
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paroxysmal nocturnal haemoglobulinuria (PNH)
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inherited disorder that manifests as hemolytic anemia because of genetic defect in GPI linkages
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properdin
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protein that stabilizes the alternative pathway C3 convertase
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S protein
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MAC inhibitor-regulatory protein
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terminal pathway
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alternative and classical pathways converge to form this pathway leading to MAC formation
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vitronectin
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MAC inhibitor-regulatory protein
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xenograft
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graft from another species
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