Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
11 Cards in this Set
- Front
- Back
Neuromuscular Blocking Drugs
|
Paralysis/Muscle Relaxation; Facilitate tracheal intubation, improve surgical working conditions, good for mechanical ventilation of lungs, treat laryngospasm; Classified/chosen according or whether Depolarizing (mimics ACh, binds receptor @ muscle and activates receptor) or Non-depolarizing (binds @ receptor and blocks ACh), duration of action (whether long, intermediate or short acting; duration also affected by liver/kidney disease so keep that in mind), speed of onset, side effects, & pathophysiology; Act by interupting transmission of nerve impulses at NMJ of muscles; review in ppt adverse effects of SUX); Note: Int= Intubation Dose, Inf= Infusion
Neuromuscular Blocking Drugs Group 3 |
|
Neuromuscular Blocking Drugs
|
Neuromuscular-blocking drugs block neuromuscular transmission at the neuromuscular junction, causing paralysis of the affected skeletal muscles.
This is accomplished either by acting presynaptically via the inhibition of acetylcholine (ACh) synthesis or release, or by acting postsynaptically at the acetylcholine receptor. While there are drugs that act presynaptically (such as botulin toxin and tetrodotoxin), the clinically-relevant drugs work postsynaptically. Clinically, neuromuscular block is used as an adjunct to anesthesia to induce paralysis, so that surgery, especially intra-abdominal and intra-thoracic surgeries, can be carried out with fewer complications. Because neuromuscular block may paralyze muscles required for breathing, mechanical ventilation should be available to maintain adequate respiration. Patients are still aware of pain even after full conduction block has occurred; hence, general anesthetics and/or analgesics must be given to prevent anesthesia awareness. |
|
Cisatracurium
Drug (trade name) |
(Nimbex)
Neuromuscular Blocking Drugs Group 3 |
|
Cisatracurium
Class |
Benzyl isoquinolinium, ND
Neuromuscular Blocking Drugs Group 3 |
|
Benzyl isoquinolinium
|
Isoquinolines find many applications, including (but not limited to): anesthetics; dimethisoquin is one example.
vasodilators, a well-known example, papaverine. |
|
Cisatracurium
Uses |
Paralysis
Neuromuscular Blocking Drugs Group 3 |
|
Cisatracurium
[ Supplied ] |
20mg vial (2mg/ml)
Neuromuscular Blocking Drugs Group 3 |
|
Cisatracurium
Dosing--card |
0.1mg/kg (0.1-0.15)
Neuromuscular Blocking Drugs Group 3 |
|
Cisatracurium
Dosing--Stever |
Int same, Inf 1-2mcg/kg/min
Neuromuscular Blocking Drugs Group 3 |
|
Cisatracurium
Caution |
Neuromuscular Blocking Drugs
Group 3 |
|
Cisatracurium
Notes |
Onset: 3-5 min
Duration: 20-35 min Hoffman Elim.,not metab in liver/kidneys, use for pt w/ renal disease Neuromuscular Blocking Drugs Group 3 |