Hematology Part 2 Hematopoiesis, Erythropoiesis

Front 1

Classical marker for hematopoietic stem cells

Back 1

CD 34

Front 2

Most widely accepted theory among experimental hematologists

Back 2

Monophyletic theory

Front 3

Chief site of hematopoiesis in mesoblastic phase

Back 3

Yolk sac

Front 4

Chief site of hematopoiesis in hepatic phase

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Fetal liver

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1st blood cells in mesoblastic phase formed during 2 to 8 weeks of life

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Primitive erythroblast

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First fully developed organ in fetus

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Thymus

Front 7

Hematopoiesis starts in the bone marrow cavity before ______ of fetal development

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5th month

Front 8

Predominant hemoglobin during hepatic phase

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Hemoglobin F

Front 9

The bone marrow becomes the chief site of hematopoiesis by the end of

Back 9

24 weeks gestation

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Process of replacing red marrow by yellow marrow during development

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Retrogression

Front 11

Between _______ years of age, adipocytes become more abundant

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5-7

Front 12

Red marrow in adults are located in

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Ribs

Sternum

Vertebrae

Pelvis

Proximal ends of long bones

Shoulder blades

Skull

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Largest of the secondary lymphoid organs

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Spleen

Front 14

Any disorder characterized by a localized enlargement of lymph nodes

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Lymphadenopathy

Front 15

Preferred sites for bone marrow aspiration in adults

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Posterior superior iliac crest

Anterior superior iliac crest

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Preferred site for bone marrow aspiration in children below 2 years old

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Tibia

Front 17

Largest cell in normal marrow

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Megakaryocytes

Front 18

M:E ratio of leukemia

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10:1

Front 19

Bone marrow smears are retained for

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10 years

Front 20

Total mass of RBC circulating in peripheral blood smear and bone marrow RBC precursors

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Erythron

Front 21

Immature hematopoietic cell that is committed to a cell line but cannot be identified

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Progenitor cells

Front 22

Immature hematopoietic stem cells that are morphologically identifiable

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Precursors cells

Front 23

Earliest marker of erythroid differentiation: transferrin receptor

Back 23

CD71

Front 24

Major hormone that stimulates the production of erythrocytes

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Erythropoietin

Front 25

Primary cell source of erythropoietin

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Peritubular interstitial cell

Front 26

Is the major way in which EPO increases RBC mass

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Apoptosis rescue

Front 27

Illegal use of EPO injections that athletes use to increase their oxygen carrying capacity

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Blood doping

Front 28

Hormone that stimulates erythropoiesis indirectly

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Testosterone

Front 29

Stimulates erythropoiesis directly

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Prolactin

Front 30

Time from BFU-E to CFU-E

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1 week

Front 31

Days for BFU-E to mature to an erythrocyte

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18-21 days

Front 32

Supravital stains for demonstration of reticulocytes

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Brilliant cresyl blue

New methylene blue

Front 33

Name of reticulocytes stained using wright stain

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Polychromatophilic erythrocytes

Diffusely basophilic erythrocytes

Front 34

Pertains to the blueness of a particular part of the cell and is due to the acidic components that attracts basic stain

Back 34

Basophilia

Front 35

Pertains to the pinkness of a particular part of the cell due to the accumulation of more basic components that attracts acid stain

Back 35

Eosinophilia

Front 36

Earliest recognizable erythroid precursor using the light microscope

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Rubriblast

Front 37

Rubriblast gives rise to ____ prorubricytes

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Two

Front 38

Prorubricytes gives to ____ rubricyte

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Four

Front 39

What stage:

Coarser chromatin

Absence of nuclei

Last stage w/ a nucleolus

First stage of hemoglobin synthesis

Back 39

Prorubricytes

Front 40

N:C ratio of rubriblast and prorubricytes

Back 40

4:1

Front 41

What stage:

Last stage capable of mitosis

First stage in which cytoplasm becomes pink

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Rubricyte

Front 42

Crushed velvet nucleus is observed in

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Lymphocytes

Front 43

Color of the cytoplasm of lymphocyte

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Sky blue or robin egg blue

Front 44

Checkerboard nucleus is observed in

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Rubricyte

Front 45

Rubricyte N:C ratio

Back 45

1:1

Front 46

Rubricyte gives rise to _____ metarubricyte

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Two

Front 47

Stage:

Last stage with a nucleus

Nucleus is pyknotic

Cytoplasm color is salmon-pink

Back 47

Metarubricyte

Front 48

Metarubricyte N:C ratio

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1:2

Front 49

Enveloped extruded nucleus

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Pyrenocyte

Front 50

Stage:

Last stage of hemoglobin synthesis

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Reticulocyte

Front 51

Number of erythrocytes produced from each rubriblast

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8-32

Front 52

Glut-1 protein function

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Glucose transporter

Front 53

Band 3 protein function

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Anion transporter

Front 54

Glycophorin C protein function

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Gerbich system determinants

Front 55

ICAM 4 protein function

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Integrin adhesion

Front 56

Only condition with increased MCHC

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Hereditary spherocytosis

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Most sensitive and specific test to confirm diagnosis of hereditary spherocytosis

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EMA binding test

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Only hereditary membrane disorder that is autosomal recessive

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Hereditary pyropoikilocytosis

Front 59

Defect in band 3 that increases membrane rigidity and resistance to malaria

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Hereditary ovalocytosis

(Southeast Asian ovalocytosis)

Front 60

Most common form of stomatocytosis

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Dehydrated hereditary stomatocytosis (xeroxytosis)