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14 Cards in this Set
- Front
- Back
Atm is responding to
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DNA damage `
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ATR will be responding to
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Replication strand
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ATM comes from ___ cells and is called this bc
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comes from AT cells
the disease ataxia telangiectasia |
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Which mutants are inviable
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ATR
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CML (chronic myelogenous leukemia):
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Philadelphia chromosome
Oncoprotein: Bcr1-Abl fusion : permanent protein kinase activity. |
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follicular lymphoma
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translocation 14-18
repressing the apoptosis signal t/cr enhancer w/ Bcr gene |
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Retnoblastomas
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Mutation in Rb w/homozygous state
- second mutation - mitotic crossing = homozgoitization -Rb-1 gene mutation |
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homozgoitization
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crossing over between the gene and the center mere, and after the divison of mitosis you inherit twice the little rb.( chances of this is much higher).
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LFS (Li Fo Syndrom)
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P53 gene mutation
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FAP (Familial adeno polypoyisis)
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APC
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P53 is the master regulations of
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apoptosis and supression
and all response to cell damage goes through p53 |
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Autonomous elements
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Ac and elements w/ similar genetic
require no other elements for their mobility |
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require no other elements for their mobility
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Ac and elements w/ similar genetic
Autonomous elements |
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nonautonomous elements
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Ds and elements w/ similar genetic
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