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81 Cards in this Set
- Front
- Back
Neurotransmitter Lifecycle |
1. Synthesis 2. Vesicle Packaging 3. Vesicle Fusion/Relase 4. Activation 5. Remove from Synaptic Cell |
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Cocaine Half Life |
45-75 minutes |
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Alcohol Synapse |
GABA Glutamine DA |
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Stimulants |
Excite CNS - blocking reuptake of dopamine, norepinephrine, serotonin |
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Cocaine Cultivated |
Coca leaf, peru, amazon, 2-8,000 ft elevation |
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Cocaine - Forms |
Paste / Hydrochloride / Freebase / Crack |
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Caffeine - CNS |
Antagonist - adenosine block |
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Most traded after petroleum |
Coffee |
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Supplements |
Unregulated, cannot be sold for specific illness |
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Alcohol metabolize |
Ethanol breakdown |
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Korsakoff Syndrome |
Severe Anterograde Amnesia |
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Major Brain Structures |
Cortex / Basal Ganglia / Hypothalamus / Limbic / Midbrain, pons, medulla |
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Basal Ganglia |
Muscle Tone |
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Midbrain |
Emotion, location memory, physical activity |
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MAOI |
Antidepressant |
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1970 Comprehensive Drug Abuse Prevention |
DHS - more funding DEA - control |
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Laissez- Faire |
Toxicity, Dependence, Crime |
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Dopamine |
Neurotransmitter found in Basal Ganglia. Feel good |
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Neuron |
Cell body - Nucleus Dendrites - Receptors Axon - Conduct Activation Presynap Terminal - End of axon |
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Glia cells |
Firmness and structure |
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Sympathetic |
Fight or Flight |
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Parasympathetic |
Recover |
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Somatic Nervous System |
External, Sensory, Cranial, Vision, Hearing, Taste |
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Psychoactive Principle |
Not good or bad / multiple effects / size quality / history expectations |
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Replaced barbiturates |
Benzodiazepine |
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Non-benzodiazepines |
Sleep |
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Benzodiazepine trade names |
Rohypnol, xanax, ativan |
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Designer Drug Meth |
Ecstasy |
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Highly Dependent Illicit Drugs |
Heroin (IV) Crack |
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Drugs/Crime |
Changes personality, under the influence, obymtain money, illicit drug use is a crime |
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4 drugs that triggered federal law |
Marijuana, Amphetamine, Barbiturates, Hallucinogens |
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1970 Controlled Abuse Substance Act |
Direct Federal regulations DHS increased funding, DEA created to oversee |
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1988 Amendments |
Target Users and Organized Crime |
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1906 |
FDA Pure Act - Labeling |
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Harry Anslinger |
1937 Marijuana Tax Act |
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Schedule 1 vs Schedule 2 |
Medical acceptance |
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Homeostasis |
Staying the same - body temp, blood pressure |
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Glia vs Neuron |
Neurons - nerve cells that analyze and transmit to Glia cells within brain |
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Sympathetic Neurotransmitter |
Norepinephrine |
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Parasympathetic Neurotransmitter |
Acetylcholine |
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Basal Ganglia |
Dopamine - Muscle Tone |
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Mesolimbic Pathway |
Assist with dependence, electrical stimulation, postive reinforcement |
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Alzheimes |
Acetylcholine - nucleus baslia |
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Inhibitory Neurotransmitter |
GABA |
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Excitory Neurotransmitter |
Glutamine |
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Drugs interact with neurotransmittera |
At Synapse or directly with Receptors |
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Herion |
Opioid |
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Cocaine |
Stimulant |
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Alcohol |
Depressant |
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LSD |
Hallucinogen |
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Prozac |
Psychotherapeutic |
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LD50 > ED50 |
Lethal > Effective |
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Deactivation |
Excreted / unchanged / no longer same effect |
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Monoamine theory of mood |
Too little MA neurotransmitter such as serotonin and dopamine cause depression |
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Dosage questions |
Effective dose? Toxic? Safety Margin? Adverse Reaction? |
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Metabolite |
Product of enzyme action |
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Presence at certain concentration |
Specific drug effects |
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Multiple Sclerosis |
Loss of Glia |
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Time Course |
Admin of drug and effect over time |
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Ataxia |
Uncoordinated Walking |
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Small intestine |
Organ absorption blood stream |
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Nalaxone |
Opioid antagonist herion addiction - generic name |
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Deltoid Muscle |
Rapid absorption |
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Safety Margin |
Difference between effective and toxic |
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Invented Opioids |
China |
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Low dose - sedative High dose Sleep |
Depressant |
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Upper |
Stimulant |
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Downers |
Depressant |
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Monoamine neurotransmitter |
Dopamine, norepinephrine, serotonin |
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Cocaine / amphetamines |
Monoamines - high dependence |
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Synthetic sympathomimetic |
Amphetamine |
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Mariana |
Coca wine |
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Freud |
Depression |
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Halsted |
Anethshia |
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Increased inhibitory GABA |
Barbiturates Benzodiazepine |
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Mental hospital odor |
Paraldehyde |
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Barbiturates |
GABA receptor |
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Sedative hypnotic withdrawal |
Anxiety, irritability, insomnia |
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Fluid balance |
AntiDiuretic hormone decrease |
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Rapid onset |
Psychological dependence |
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Short duration |
Withdrawl symptoms |