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6 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Nitrates |
MOA: Metabolism of nitrates produces NO which leads to Increase production of cGMP resulting in a cascade of events causing vasodilation. Glyceryl Trinitrate Isorbide Mononitrate |
Headache, postural hypertension, methaemoglobinemia. |
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Beta-Blockers |
MOA: bind to beta adrenergic receptors preventing binding of norepinephrine Propanolol (non selective) Metprolol (Beta selective) Atenolol (Beta selective) |
Bronchoconstriction, Bradycardia, Heart failure |
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Calcium Channel Blockers |
MOA: Prevent entry of calcium through calcium channels to prevent excitation coupling. Verapramil - mainly heart Nifidepine (DHP) |
DHP: Flushing, headache, Non-DHP: Constipation |
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K+ Channels Activators |
MOA: Promote K+ efflux causing hyperpolarization that inhibits calcium channels resulting in relaxation. Nicorandil |
Cannot be used together with sidenafil (viagra) Headache, diziness, flushing |
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ACEI/ARB |
MOA: Used to prevent scar remodeling of heart after MI ACEI - enalapril, captopril ARB - Valsartan, Losartan, |
Dry cough, first dose hypotension, impaired renal function. |
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Ranolazine |
MOA: Blocks late inwards sodium current and thus decreasing intracellular calcium. Used in addition to other beta blockers, nitrates and CCB |
Dizziness, confusion, nausea, vomiting |
