Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
25 Cards in this Set
- Front
- Back
|
What does cM stand for?
|
centimorgans
|
|
|
What does m.u. stand for?
|
map units
|
|
|
What was the first human disease gene to be successfully mapped by positional cloning?
|
Huntington disease (HD)
|
|
|
Southern blotting
|
A process where researchers separate DNA fragments by electrophoresis, blot the separated fragments to a special filter paper, and then examine the bands
|
|
|
TDF is?
|
testes-determining factor
|
|
|
copasetic
|
very good; excellent; completely satisfactory
|
|
|
incontrovertible
|
incontestable, undeniable, unquestionable
|
|
|
controvert
|
to argue against; dispute; deny; oppose
|
|
|
transgenic plant/animal
|
an individual carrying a transgene
|
|
|
What are the symptoms of cystic fibrosis?
|
Abnormally viscous secretions in the lungs, pancreas, and sweat glands
|
|
|
vetting
|
to examine or treat in one's capacity as a veterinarian or as a doctor
|
|
|
positional cloning
|
the process that enables researchers to obtain the clone of a gene without any prior knowledge of its protein product or function. It uses genetic and physical maps to locate mutations responsible for particular phenotypes
|
|
|
linkage map
|
depicts the distances between loci as well as the order in which they occur on the organism
|
|
|
transgenic technology
|
the tools for inducing a specific change in a gene and confirming that this change causes the predicted phenotype. Transgenic technology includes experimental methods that allow scientists to add laboratory-constructed DNA sequences to the genomes of animals or plants
|
|
|
transgene
|
any piece of foreign DNA that researchers have inserted into the genome of an organism
|
|
|
targeted mutagenesis
|
alters the DNA sequence of a particular gene or regulator region in a predetermined way.
|
|
|
LOD score analysis
|
logarithm of the [od]ds analysis; stastistical method for determining the likelihood that two or more loci are linked together on the same chromosome
|
|
|
phase of linkage
|
haplotype confirgurations
|
|
|
knockout mice
|
mice homozygous for an induced mutation in a targeted gene; the mutation destroys (knocks out) the functional gene
|
|
|
phenocopy
|
a change in phenotype arising from environmental agents that mimic the effects of a mutation in a gene.
Phenocopies are not heritable because they do not result from a change in a gene |
|
|
quantitative trait loci (QTLs)
|
loci that control the expression of continuous traits
|
|
|
haplotype is short for?
|
haploid genotype
|
|
|
haplotype
|
a specific combination of two or more DNA marker alleles on the same homolog
|
|
|
linkage disequilibrium
|
when alleles at separate loci are associated with each other at a significantly higher frequency than would be expected by change
may be indicative of common ancestry |
|
|
paternity
|
the state of being a father; fatherhood
|
