Chapter 10 Review: B Cell Development

Front 1

Where are the early sites of blood-cell development?

Back 1

Yolk sac, placenta, aorta-donad metanphros, and fetal liver

Front 2

What do the earliest B-cell progenitors in the fetal liver supply?

Back 2

B-1 B cells

Front 3

Where do B-1 B cell migrate?

Back 3

Pleural and peritoneal cavities

Front 4

T/F B1 B-cells are self-renewing

Back 4

T

Front 5

What Ig rearrangements occur 1st? 2nd?

Back 5

D to Jh in Variable genes

Vh to DJh

Front 6

Where do Immature B cells migrate to and mature? What are these cells called?

Back 6

T-1 (transitional) B 2 B-cells

Spleen

Front 7

What happens when T1 B-2 B cells enter the follicles?

Back 7

Increase IgD and become T2 cells

Front 8

What is the fate of the subsequent T2 cells?

Back 8

Can become follicular (traditional) or marginal zone B cells

Front 9

Can B cells undergo somatic hypermutation?

Back 9

yes; forms memory after Ag stimulation

Front 10

Do B cells need to recognize MHC?

Back 10

N

Front 11

Where do B-1 B cells come from and where would you look for them

Back 11

Fetal liver; pleural and peritoneal cavities

Front 12

T/F T1 T cells have intermediate amount of IgD

Back 12

F; T2 have high, T1 are low

Front 13

What surface markers are found on T2 cells, that are not on T2 (2) ?

Back 13

CD21 and CD23

Front 14

What happens when Ag encounters T1 cells? T2?

Back 14

T1 - Apop

T2 - survival and maturation

Front 15

What is the purpose of cell divison in B cells, post pre-B-cell R appearance?

Back 15

• maximize use of HC rearrangement
• Daughter cells can under go LC rearrangement
• Gives rise to multiple clones with same HC but different LC

Front 16

3 Ways to manage auto-immunity of B cells

Back 16

1. Apoptosis - Bone marrow for B, Thymus for T
2. Anergy - Both can do this
3. Receptor editing - Unique to B cells

Front 17

Good marker for mature B cell

Back 17

CD20

Front 18

Major Ig of B cells

Back 18

IgM

Front 19

Where are B-2 B cells found

B-1?

MZ?

Back 19

2ndary Lymphoid organs

Pleural and peritoneal cavities

Spleen

Front 20

source of

B2

B1

MZ

Back 20

Precursors in BM

Self renewing

Self renewing

Front 21

V Region Diversity of

B1

B2

MZ B

Back 21

B1 - restricted diverstiy

B2 - Highly divserse

MZ - Somewhat divsers

Front 22

Requirement for T cell help

B1

B2

MZ

Back 22

B1 no

B2 - yes

MZ - variable

Front 23

Isotypes produced

B1

B2

MZ B

Back 23

B-1 IgM

B2 : IgG

MZ: IgM, some IgG

Front 24

Respond to carbohydrate

B1

B2

MZ B

Back 24

B1 Yes

B2 no

MZ yes

Front 25

Respond to protein Ag

B1

B2

MZ B

Back 25

B1 - maybe

B2 - yes

MZ - yes

Front 26

Memory

B1

B2

MZ B

Back 26

B1 - no

B2 - yes

MZ - ?

Front 27

Surface IgD

B1

B2

MZ B

Back 27

B1 No

B2 - On Naive

MZ - no