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23 Cards in this Set
- Front
- Back
6 Inner mitochondrial membrane proteins for ETC (In order of the chain)
(Embedded, inside, or outside inner membrane of mitochrondria???) |
1. NADH dehydrogenase complex (Embedded) (Complex 1)
2. ubiquinone (Inside) 3. Succinate Dehydrogenase (Outside) (Complex II - for FADH2) 4. Cytochrome b-c complex (Embedded) (Complex III) 5. Cytochrome c (outside) 6. Cytochrome Oxidase complex (Embedded) (Complex IV) |
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Which of the 2 components in ETC are mobile carriers? Not complexes
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Ubiquinone (Coenzyme Q10 (Q10 or CoQ) and Cytochrome C
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What is special about Succinate Dehydrogenase?
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Used in TCA cycle for FADH2 (converted back into FAD)
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What is special about Ubiquinone?
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Coenzyme Q10 (Q10 or CoQ)
Not protein but large complex organic lipid soluble organic mobile electron carrier |
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What is special about Cytochrome C?
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Small protein that contains Heme group.
Highly conserved |
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What is involved in all 4 clusters (metal)?
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Iron
(Iron sulphur clusters and heme groups) |
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Which metal is in complex 4?
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Copper
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What are the 3 proton pumping sites?
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NADH dehydrogenase (complex I)
Cytochrome bc1 complex (Complex III) Cytochrome oxidase (Complex IV) |
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Rotenone, an insecticide, inhibits at ________
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complex I
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Antibiotic Antimycin A inhibits at complex _______
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Complex III
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Cyanide, Azide, CO inhibit at _______
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complex IV
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Ceramide inhibits _______
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complex III
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Methamphetamine inhibits _______
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Complex IV
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Barbiturates inhibit at _______
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Complex I
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3 ways ATP can be synthesized
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1. Substrate level phosphorylation
2. photophosphorylation 3. Oxidative phosphorylation |
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Substrate Phosphorylation?
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Direct transfer of phosphate group from a sugar phosphate to ADP = ATP
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Photophosphorylation?
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ATP generated during photosynthesis in chloroplasts of plant/algae cells.
Protons go to THylakoid space and back into stroma to generate ATP |
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Oxidative Phosphorylation (OxPh)
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Prokaryotes = plasma membrane
ATP formed via ATP synthase Chemiosmosis |
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Chemiosmosis? Creates what?
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Generating ATP from proton gradient = forming Proton Motive Force
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ATP Synthase important info
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pumps protons from Mitochondrial Matrix into intermembrane space
Complex V of respiratory system Located on inner mitochondrial membrane Can hydrolyze ATP also |
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2 components of ATP synthase
3 named parts of ATP synthase? |
F[1] and F[0]
Catalytic Head, Stalk, and Rotor |
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What happens when ETC and ATP synthase are uncoupled
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H+ does not travel back through ATP synthase (ETC continues but ATP synthase does not)
Energy released as heat - hibernation |
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P/O ratio tells us?
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tells us how many moles of ATP are made for each mole of oxygen atom used
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