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15 Cards in this Set
- Front
- Back
Where does glycolysis occur?
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In the cytosol.
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Why are intermediates phosphorylated?
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> Phosphorylated intermediates have no way to leave cell.
> High energy intermediates transfer phosphoryls to ADP. > Enzyme Active Sites bind and interact with phosphate groups (increases enzyme specificity. Lowers AE of a rxn) |
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What are the three irreversible reactions that are regulated in glycolysis?
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> Hexokinase (step 1)
> Phosphofructokinase (PKF1) (step 3) > Pyruvate Kinase (step 10) |
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HEXOKINASE
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Glucose -----------> G6P
-Irreversible -Regulated -Requires ATP (First investment) |
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Phosphoglucoisomerase
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G6P <-----> F6P
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Phosphofructokinase
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F6P --------------> F1,3bP
-Irreversible -Regulated -Requires ATP (second investment) |
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Aldolase
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F1,3bP <-------------> Hydroxy Acetate Phosphate/Glyceraldehyde 3-Phosphate
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Glyceraldehyde 3-Phosphate Dehydrogenase
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Glyceraldehyde 3-Phosphate /NAD+ <---->1,3bP /NADH (x2)
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Phosphoglycerate Kinase
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1,3-bP /ADP <-------> 3PG / ATP (x2)
-First Pay off |
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Phosphoglycerate Mutase
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3GP <---------> 2GP (x2)
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Enolase
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2GP <-------> Phosphoenol Pyruvate
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Pyruvate Kinase
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Phosphoenol Pyruvate /ADP---------------> Pyruvate /ATP
-Irreversible -Second Payoff |
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Lactate Dehydrogenase
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L-Lactate
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Pyruvate decarboxylase
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Pyruvate <-----> Acetaldehyde
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Alcohol Dehydrogenase
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Acetaldehyde <-----> Ethanol
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