Biochem Enzymes (1-3)

Front 1

T/F Enzymes are proteins

Back 1

True

Front 2

Proteins that act as a catalyst for biochemical reactions

Back 2

Enzymes

Front 3

T/F Enzymes are a true catalyst

Back 3

True

Front 4

T/F At the end of the reaction, enzymes converted to something else

Back 4

False, enzymes remain unchanged at the end of the reaction

Front 5

What are the secondary structures present in CHYMOTRYPSIN

Back 5

Alpha helix, Beta pleated sheet

Front 6

T/F Chymotrypsin is considered as globular protein

Back 6

True

Front 7

T/F Enzymes can undergo denaturation

Back 7

True

Front 8

T/F Every biochemical reaction in the body is accompanied by an specific enzymes

Back 8

True

Front 9

Enzymes are subdivided into two classes;

Back 9

Simple Enzyme-only has an amino acid side chain

Conjugated Enzyme- has non protein part + protein part

Front 10

Part of the conjugated enzyme that refers to the protein part

Back 10

Apoenzyme

Front 11

It includes all the non-protein parts found in the conjugated enzyme

Back 11

Cofactor/Coenzyme (one kind of cofactor)

Front 12

Apoenzyme combined with the Cofactor is called ___________. It is the whole conjugated enzyme that is biologically functional/can catalyze reaction

Back 12

Holoenzyme

Front 13

Holoenzyme + Substrate =

Back 13

Product

Front 14

T/F Substrate is part of the conjugated enzyme

Back 14

False

Front 15

Cofactor is subdivided into two:

Back 15

•Small Organic Molecules

•Inorganic Ion

Front 16

Derives from dietary minerals

Back 16

Inorganic Ion

Front 17

Derived from dietary vitamins

Back 17

Small Organic Molecules

Front 18

If the co-factor is organic, it has a specific name which is called __________

Back 18

Co-enzyme

Front 19

Minerals for tooth and bone formation

Back 19

Calcium

Front 20

Sources of calcium

Back 20

Milk and other dietary products

Front 21

For bone development and transfer of energy in cells

Back 21

Phosphorus

Front 22

Sources of Phosphorus

Back 22

Most foods

Front 23

For nerve transmission and muscle contraction

Back 23

Sodium

Front 24

Sources of Sodium

Back 24

Meat, salt, dietary products

Front 25

For formation of HCl

Back 25

Chlorine

Front 26

Sources of Chlorine

Back 26

Salt

Front 27

For regulation of hearbeat, maintainance of water balance, nerve transmission

Back 27

Potassium

Front 28

Sources of Potassium

Back 28

Fruit(banana)

Front 29

For catalyst for ATP formation

Back 29

Magnesium

Front 30

Sources of Magnesium

Back 30

Nuts, grains, dark green vegetables, sea food, chocolate

Front 31

For thyroid activity

Back 31

Iodine

Front 32

Sources of iodine

Back 32

Sea foods, salt

Front 33

For Hemoglobin formation

Back 33

Iron

Front 34

Sources of Iron

Back 34

Meat, green vegetables, dried fruits

Front 35

Reactant in an enzyme-catalyzed reaction

Back 35

Substrate

Front 36

The suffix -in found in the name of some __________ enzymes

Back 36

Digestive

Front 37

Enzymes that catalyzes an oxidation reaction

Back 37

Oxidase

Front 38

Enzymes that catalyze a hydrolysis reaction

Back 38

Hydrolase

Front 39

Enzymes can be named based on what?

Back 39

•Type of Reaction

•Identity of the substrate

•General nature of Substrate

Front 40

Who created/developed the name of the enzymes and anything else that is related to biochemistry

Back 40

International Union of Biochemistry and Molecular Biology (IUBMB)

Front 41

Major class of enzyme that involves oxidation-reduction reaction catalyzed

Back 41

Oxidoreductases

Front 42

Major class of enzyme that involves the reaction of functional group transfer reactions

Back 42

Transferases

Front 43

Major class that involves hydrolysis reaction

Back 43

Hydrolases

Front 44

Major Class that involves the reactions involving addition or removal of groups form double bonds

Back 44

Lyases

Front 45

Major class that involves isomeration reactions

Back 45

Isomerase

Front 46

Major class that reactions involving bond formation coupled with ATP hydrolysis

Back 46

Ligases

Front 47

Enzymes under oxidoreductase that involves oxidation of the substrate

Back 47

Oxidase

Front 48

Enzymes under oxidoreductase that involves reduction of the substrate

Back 48

Reductases

Front 49

Enzymes under oxidoreductase that involves the introduction of a double bond (oxidation) by formal removal of 2 H atoms from substrate, the H being accepted by a coenzyme

Back 49

Dehydrogenases

Front 50

Enzymes under transferases that involves the transfer of an amino group between substrates

Back 50

Transaminases

Front 51

Enzymes under transferases that involves the transfer of a phosphate group between substrates

Back 51

Kinases

Front 52

Enzymes under hydrolase that involves the hydrolysis of ester linkages in lipids

Back 52

Lipases

Front 53

Enzymes under hydrolase that involves the hydrolysis of amide linkages in protein

Back 53

Proteases

Front 54

Enzymes under hydrolase that involves the hydrolysis of sugar-phosphate ester bonds in nucleic acid

Back 54

Nucleases

Front 55

Enzymes under hydrolase that involves the hydrolysis of glycosidic bonds in carbohydrates

Back 55

Carbohydrases

Front 56

Enzymes under hydrolase that involves the hydrolysis of phosphate-ester bonds

Back 56

Phosphotases

Front 57

Enzymes under lyases that involves the removal of H2O from substrate

Back 57

Dehydratases

Front 58

Enzymes under lyases that involves the removal of CO2 from substrate

Back 58

Decarboxylases

Front 59

Enzymes under lyases that involves the removal of NH3 from substrate

Back 59

Deaminases

Front 60

Enzymes under lyases that involves the addition of H2O to a substrate

Back 60

Hydratases

Front 61

Enzymes under isomerases that involves the conversion of D to L isomer or vice versa

Back 61

Racemases

Front 62

Enzymes under isomerases that involves the transfer of a functional group from one position to another in the same molecule (has only one reactant and one product)

Back 62

Mutases

Front 63

Enzymes under ligases that involves the formation of new bond between 2 substrates with participation of ATP

Back 63

Synthetases

Front 64

Enzymes under ligases that involves the formation of new bond between a substrate and CO2 with participation of ATP

Back 64

Carboxylases

Front 65

Specific location found in the enzyme where the substrate binds

Back 65

Active site

Front 66

T/F Enzymes only have 1 active site

Back 66

False

Front 67

Intermediate reaction species formed when substrate binds with the active site

Back 67

Enzyme Substrate Complex

Front 68

T/F There are 3 models for substrate binding to enzymes

Back 68

False, 2 only

•Lock and key model

•Induced Fit model

Front 69

Who proposed the lock and key model

Back 69

Fischer

Front 70

Who proposed the Induced Fit model

Back 70

Koshland

Front 71

T/F Fischer mechanism has an active site that fixed in shape

Back 71

True

Front 72

T/F Koshland Mechanism has an active site that adapts to substrate

Back 72

True

Front 73

T/F Active site is symmetric

Back 73

False

Front 74

T/F There is no reaction between the substrate and the sidechains of amino acids in the enzymes

Back 74

False

Front 75

Each enzyme molecule can transform __________ substrate molecules into product each second

Back 75

100-1000

Front 76

T/F Enzymes are 10^3-10^8 faster than uncatalyzed reaction

Back 76

True

Front 77

Catalytic Efficiency

Back 77

Gano ka efficient enzymes

Front 78

The number of substrate molecules that an enzyme molecule can process per second when saturated with the substrate

Back 78

Turnover number

Front 79

T/F Turnover number is equivalent to the catalytic rate constant (kcat)

Back 79

True

Front 80

T/F Enzymes are lowly specific

Back 80

False

Front 81

T/F Enzymes can interact with more substrate

Back 81

False, 1 or few only

Front 82

T/F Enzymes can catalyze 2 types of chemical reaction

Back 82

False, only 1

Front 83

Nonprotein portion of the enzyme that is needed for enzymic activity

Back 83

Cofactor

Front 84

T/F Enzymes can be activated or inhibited so that the rate of product formation responds to the need of the cell

Back 84

True

Front 85

T/F Many enzymes are localized in specific organelles within the cell (compartmentalized)

Back 85

True