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22 Cards in this Set
- Front
- Back
Drugs that Inhibit P450
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"Some Pharmaceutical Classes Inhibit Drug Catabolism"
Sulfonamides Phenylbutazone Chloramphenicol Isoniazid Cimetidine Dicumerol |
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Bad drug interactions
-AG & Loops -MAOIs & SSRIs -MAOIs & TCAs -Antiarrythmics & FQs -Cation-containing durgs/citric acid & FQ -Alcohol/rifampin & isoniazide |
-Nephrotoxicity & ototoxicity
-Serotonin syndrome -Serotonin syndrome or severe SNS activation -prolonged QT -severe impairment of FQ absorption -liver damage --> liver failure |
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Drugs that cause HTN crisis
(malignant HTN & tachycardia) |
MAOI
TCAs |
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Drug that causes NAION
(non-arteritic anterior ischemic optic neuropathy) |
PDE-5 inhibitors
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Drugs that cause neurotube defects
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Carbamazepine
Valporic Acid |
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Drugs that cause ototoxicity
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AG
PDE-5 inhibitors (permanent vision & HL) |
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Drugs that cause drug-induced lupus
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Hydralazine
Procainamide |
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Drug causes G6PD exacerbation
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Sulfa
Primaquine |
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Drugs that Induce P450
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"One Pharmaceutical Brings About Rapid Liver Metabolism"
OCP Phenytoin Barbiturates Alcohol Rifampin Levodopa Methadone |
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Drugs that are easily displaced from albumin
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"Serum Proteins Can Spew"
Sulfonamides Phenylbutazone Coumadin Sulfonylureas |
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Drugs that compete at renal trasporters
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"Some Pharmaceuticals Plus Urate Stop Transporters"
Sulfonamides Probenecid Penicillin Urate Salicylates Thiazides |
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Drugs that cause Bone Marrow Toxicity
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Most chemotherapeutic agents
Chloramphenicol Ganciclovir Zidovudine (AZT) Interferon Flucytosine Carbamazepine |
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Drugs that cause Hepatotoxicity
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All imidazoles
Interferon Nevirapine all HMG CoA inhibitors Valportic Acid Isoniazid |
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Drugs that cause nephrotoxicity
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AG
Foscarnet Cidofovir NSAIDs Cyclosporin Amphotericin |
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Drug that causes tendon rupture
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Quinolones
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Drugs that cause DVTs
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Raloxifene
Tamoxifen Estrogen/Progesterone |
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Drugs that cause orthostatic hypotension
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All alpha blockers
most TCAs |
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Drugs that cause serotonin syndrome
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MAOIs
SSRIs Decongestants TCAs SNRIs |
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Drug that causes cutaneous flushing
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Niacin
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Drug that causes seizures
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Meperidine
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Drug that causes malignant hyperthermia
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Halothane
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Drug that causes Ebstein's anomaly
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Lithium
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