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12 Cards in this Set
- Front
- Back
Sulfonylureas
MOA |
- stimulate insulin release from beta cells of pancreas
- reduce serum glucagon - increase insulin binding to receptor |
|
Sulfonylureas
how excreted |
liver and kidney
|
|
Sulfonylureas
contraindications |
- patients with hepatic and renal insufficiency
- pregnant animals (depletes fetal insulin) |
|
Meglitinide analogs
how used? |
- as postprandial glucose regulators
- used w/ other hypoglycemics drugs (ex Metformin) |
|
Meglitinide analogs
excretion and contraindications |
- bile
- patients w/ hepatic inpairment |
|
Metformin
what does it do? |
-increases glucose uptake
-sensitizes tissue to insulin action -reduces hepatic gluconeogenesis -slows intestinal glubose reabsorption |
|
Metformin
side effects how excreted |
-GI disturbances
-kidney |
|
Glitazones
have what effect |
- sensitize target tissue to insulin
-lower insulin resistance |
|
Glitazones
side effects |
hepatotoxicity and edema
|
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alpha glucosdase inhibitors
cannot be used with what drug? |
metformin (decreases bioavailablity)
|
|
alpha glucosdase inhibitors
side effects |
flatulence, diarrhea, abdominal cramps
|
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alpha glucosdase inhibitors
MOA |
- inhibits alpha glucosdase -> inhibits oligosaccharide hydrolysis
- inhibits secretion of alpha amylase from pancreas -> inhibit starch breakdown |