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10 Cards in this Set
- Front
- Back
when do these drugs work best?
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In G1 and S phase but CAN work outside of that.
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Mechanism of action of alkylating agents?
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drugs are electrophilic and they attack the N7 position on guanine resulting in DNA damage by inter/intra strand cross linking, abnormal base pairing, DNA strand breakage
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Resistance to alkylating agents?
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increased repari, decreased permeability to drug and increased production of thiol trapping agents
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Prototype of alkylating agents?
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cyclophosphamide
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toxicity of cyclophosphamide?
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GI, myelosuppression, alopecia, HEMORRHAGIC CYSTITIS from acrolein (helped with mesna). cardiac dysfunction and pulmonary toxicity, inappropriate ADH secretion
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What type of drug is mechorethane?
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DNA alkylating agents
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Toxicity of mechlorethane/
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same and secondary cancer due o to induction of mutations in healthy tissues
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what is special about nitrosoureas?
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very greasy can cross BBB and are used for brain tumors
they have high CNS toxicity |
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What is the toxicity of platinum agent cisplatinum?
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cisplatinum has little bone marrow effect. GI distress, mild hematotoxicity, neurotoxicity, NEPHROTOXICITY - which can be reduced with forced hydration.
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toxicity of carboplatin?
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Less nephrotoxic than cis but cause myelosuppression and hearing loss
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