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41 Cards in this Set
- Front
- Back
What will GC do in relation to stress?
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Inc: gluconeogenesis
glycogen synthesis BG catbolism (breakdown) |
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How are GC anti-inflammatory?
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Dec. leukocytes, cytokine, chemokines, macrophage and COX II expression
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Long duration GC
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Betamethasone
Dexamethasone |
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2 MC
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fludrocortisone
desoxycorticosterone |
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Chronic AC insufficiency
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Addison's disease
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Treatment for Addisons or congenital adrenal hyperplasia
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hydrocortisone (GC)
fludrocortison (MC) |
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What is the treatment for Cushings
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surgery
irradiation large dose cortisol->reduced dose |
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Treatment for aldosteronism
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Spironolactone
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What can be given IM maternall to inc. fetal lung maturation
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betamethasone
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What kind of diet should someone with GC toxicity be on?
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high protein
high potassium |
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GC are contraindicated in what populations?
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PUD heart disease
CHF Infxn Psych DM Osteo glaucoma |
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Precursor to aldosterone
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deoxycorticosterone
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Most commonly used MC
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fludrocortisone
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Drugs that inhibits synthesis of cortisol and used to test adrenal fxn
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Metyrapone
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Antifungal that inhibits adrenal and gonadal steroid
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ketoconazole
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Anti-progestin and GC, will reverse cushingoid effects
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Mifepristone (RU486)
|
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Competes with aldosterone sites
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Spironolactone
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Aldosterone antoagonist used to treat HTN
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Eplerenone
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3 endogenous estrogens
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estradiol
estrone estriol |
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4 estrogens, not estradiols
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DES
Quinestrerol Chlorotrianisene Methallenestril |
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2 clinical uses of estrogen
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1* hypogonadism
ERT |
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If woman had hysterectomy-how do you prescibe HRT?
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can use estrogen alone
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What kind of cancer does progestin prevent
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Endometrial
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Where is progesterone synthesized
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ovary
testes adrenals placenta |
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Effects of progesterone
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Inc. lipoprotein lipase -> inc. fat deposition
maturation of endometrium after ovulation |
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Competitive partial estrogen agonist used to treat breast Ca post menopause
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tamoxifen
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Partial estrogen agonist prevent post menopausal osteroporosis
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raloxifene
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Partial estrogen agonist that induces ovulation
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Clomiphene
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Weak progestin, androgen, & GC suppresses ovaries
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Danazol
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Testosterone is converted to dihydrotestosterone by what?
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5 alpha reductase
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Drug that inhibits 5 alpha reductase-used for BPH, male pattern baldness, hirsutism
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Finasteride
|
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4 Androgen RH analogs
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Goserelin
nafarelin Buserelin Leuprolide |
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Drug used to treat excessive libido, female hirutism
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Cyproterone
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Sub Q rDNA PTH used to treat osteoporosis
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Teriparatide
|
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Vit D first hydroxylated in the liver to form
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Calcifediol
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25 OH vit. D further converted in the kidney to
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Calcitriol
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Hormone secreted by thyroid to decrease calcium concentration
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Calcitonin
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How do GC effect calcium?
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Antag. Vit. D intestinal transport by stim. renal excretion of Ca++
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Group of drugs that inhibit bone resorption. Treat Paget's and osteoporosis
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Biphosphonates
Etidronate Pamidronate Alendronate Risedronate Tiludronate Zoledronate |
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s/s hypocalcemia
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tetany
laryngospasm muscle cramps convulsions |
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Drug that protects against spine fractures, but not hip
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Raloxifene
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