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29 Cards in this Set
- Front
- Back
LIPID METABOLISM
- Two-Thirds (2/3) of cholesterol is esterified by what? |
- Lecithin-Cholesterol Acyltransferase
(LCAT) |
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LIPID METABOLISM
- Pancreatic Lipase degrades what TG's? - these TG's are located where? |
- Dietary TG
- small intestine |
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LIPID METABOLISM
- Lipoprotein Lipase (LPL) degrades what TG's? - these TG's are located where? |
- Circulatory TG
- in Chylomicrons & VLDL's |
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LIPID METABOLISM
- Hepatic TG Lipase (HL) degrades what TG's? - these TG's are located where? |
- TG's remaining in IDL
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LIPID METABOLISM
- Hormone-Sensitive Lipase degrades what TG's? - these TG's are located where? |
- TG's stored in Adipose
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LIPID METABOLISM
- Cholesterol Ester Transfer Protein (CETP) mediates what? |
- Transfer of Cholesterol to other Lipoprotein particles
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LIPID METABOLISM
- Apolipoprotein A-1 function? |
(A = A)
- Activates LCAT |
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LIPID METABOLISM
- Apolipoprotein B-100 function? |
(B=B)
- Binds to LDL receptor & mediates VLDL secretion |
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LIPID METABOLISM
- Apolipoprotein C-II function? |
(C=C)
- Cofactor for LPL |
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LIPID METABOLISM
- Apolipoprotein B-48 function? |
- mediates Chylomicron secretion
|
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LIPID METABOLISM
- Apolipoprotein E function? |
(E=E)
- mediates Extra (remnant) Uptake |
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LIPID METABOLISM
- which apolipoprotein mediates Chylomicron secretion? - which apolipoprotein mediates VLDL secretion? |
- B-48
- B-100 |
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LIPID METABOLISM
- which apolipoprotein is needed for LCAT? - which apolipoprotein is needed for LDL? |
A-I
C-II |
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LIPID METABOLISM
- which Lipoprotein carries most of the cholesterol? |
- LDL
- HDL |
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LIPID METABOLISM
- transports cholesterol from Liver to Tissues? |
(LDL is Lousy)
- LDL |
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LIPID METABOLISM
- transports cholesterol from peripheral Tissues to Liver? |
(HDL is Healthy)
- HDL |
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LIPID METABOLISM
- Carries Cholesterol to peripheral tissue - Carries DIETARY TG to peripheral tissue - Carries HEPATIC TG to peripheral tissue |
- LDL
- Chylomicrons - VLDL |
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LIPID METABOLISM
- can deliver cholesterol to Liver - can deliver cholesterol to Liver in the form of remnants (mostly depleted of triacylglycerols) |
- HDL
- Chylomicrons |
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LIPID METABOLISM
- which lipoprotein is secreted by INTESTINAL Epithelial cells? |
- Chylomicrons
|
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LIPID METABOLISM
- which lipoprotein is secreted by the LIVER? |
- VLDL
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LIPID METABOLISM
- HDL is secreted from where? |
- Liver
AND - Intestine |
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LIPID METABOLISM
- degradation of VLDL forms? - occurs where? |
- IDL (in the Liver)
- LDL (in the Peripheral Tissue) |
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LIPID METABOLISM
- formed by LPL modification of VLDL - where? |
- LDL
- Peripheral Tissue |
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LIPID METABOLISM
- taken up by Target cells - via what process? |
- LDL
- Receptor mediated Endocytosis |
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LIPID METABOLISM
- HDL acts as a repository for what apolipoproteins? - these apolipoproteins are important for what? |
- apoC
- apoE - Chylomicron metabolism - VLDL metabolism |
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LIPID METABOLISM
- Chylomicron apolipoproteins |
A-4
B-48 C-2 E |
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LIPID METABOLISM
- VLDL apolipoproteins |
B-100
C-2 E |
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LIPID METABOLISM
- IDL apolipoproteins |
B-100
E |
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LIPID METABOLISM
- LDL apolipoproteins |
B-100
|