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10 Cards in this Set
- Front
- Back
Methotrexate inhibits cell division by blocking which phase of the normal cell cycle?
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S phase of DNA synthesis
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The anti-inflammatory affects of MTX are mediated by what?
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Adenosine
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What are the 2 FDA approved uses for MTX?
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Psoriasis and Sezary Syndrome
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Methotrexate is Pregnancy category what?
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Pregnancy category X
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What is the only absolute contraindication for MTX use?
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Pregnancy
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What organ is at risk with long-term use of MTX?
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Liver
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Pulmonary toxicity is a potential effect of what drug?
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MTX
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What is the most concerning hematologic effect of MTX?
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Pancytopenia
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CrCl less than what should make you think twice before using MTX?
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CrCl < 50
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In general a liver biopsy should be performed after what cumulative dose of MTX?
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1.5grams
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