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17 Cards in this Set
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- Back
- 3rd side (hint)
Drugs that do not cross placenta have |
High water solubility e.g(heparin) |
Safe to use during pregnancy |
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Git Drugs to avoid in patients with Parkinson |
Metoclopramide.it antagonizes dopamine receptors. |
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HIV patient with retinal hemorrhage and eye symptoms and treatment |
Suspect Cytomegalovirus retinitis.treat with ganciclovir or pro drug valgancyclovir-inhibits DNA chain elongation,inhibits DNA polymerase. |
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Patient with enterococcus treated with aminoglycoside shows drug resistant but bacterial effect when penicillin is added |
Aminoglycoside(generally used on gram negative) cannot pass through the cell wall because they work on 30s ribosomal subunit.so in order for it to work on organisms with cell wall,a drug that acts on cell wall e.g penicillin needs to be added. Used in severe cases of gram positive infection. |
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Co administration of probenecid with penicillin |
Increases serum concentration of penicillin by inhibiting renal tubular secretion of penicillin-inhibiting organic anion transporter which normally transport penicillin from the capillaries to the tubular lumen |
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Drug eluting stent like everolimus |
(sirolimus)inhibits intimal hyperplasia. They block the cell cycle from g1 to s phase to reduce smooth muscle cell proliferation by inhibiting mtor. |
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Cyp450 inducers |
Griseofulvin st John's wartCarbamazepine,phenytoinPhenobarbital Oral contraceptiveRifampin |
Decrease warfarin effect |
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Beta blocker withdrawal syndrome |
Upregulation of beta adrenergic receptors |
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Bisacodyl |
Improved peristalsis by stimulating enteric nerve |
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Not eliminated by renal or hepatic clearance |
Monoclonal antibodies |
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Drugs that undergo enterohepatic recirculation |
Irinotecan |
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Sustained released drug preparation and immediate release drug preparation differences |
Sustained Has Reduced and delayed peak due to slower absorption in the git. |
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Dantrolene |
Blocks further release of calcium into intracellular space. |
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Epinephrine and lidocaine |
Vasoconstriction prolongation. |
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Tolerance effect seen with alpha adrenergic agonist(decongestant) |
Due to receptor internalization after activation. |
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Insulin and phosphorus |
Drives phosphorus Intracellularly. |
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Proportion of body water between adult and neonates |
Neonates have higher proportion of body water. Lower plasma concentration of water soluble drugs if given the same dose as adult |
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