Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
150 Cards in this Set
- Front
- Back
Carbonic Anhydrase Inhibitor
|
Diuretic Agent
Inh CA (proximal tubule) → ↓ bicarb reabsorption, ↑ Na excretion (↓H+ IC), so ↑ K exc. Alkalinizes urine, hyper-Cl, hypo-K, metabolic acidosis, ↓ aqueous humor Tx: met alkalosis, acute mtn sickness, glaucoma, alkalinize urine CI: cirrhosis Effective for only a few days |
|
Acetazolamide
|
Diuretic Agent
Carbonic Anhydrase Inhibitor Oral |
|
Brinzolamide
|
Diuretic Agent
Carbonic Anhydrase Inhibitor Topical |
|
Dorzolamide
|
Diuretic Agent
Carbonic Anhydrase Inhibitor Topical |
|
Loop Diuretic (25% of Na)
|
Diuretic Agent
Block NaK2Cl cotransport (thick asc. loop) → ↑Na, K, Mg, Ca, H+ excretion Hypo-K, hypo-Cl, metabolic alkalosis, ototoxic, heavy diuresis Tx: CHF, pulm edema, acute renal failure, hyper-K, hyper-Ca CI: avoid NSAIDs, Oral |
|
Furosemide (Lasix)
|
Diuretic Agent
Loop Diuretic (25% of Na) |
|
Torsemide
|
Diuretic Agent
Loop Diuretic (25% of Na) Lower dose |
|
Bumetanide
|
Diuretic Agent
Loop Diuretic (25% of Na) Lower dose |
|
Ethacrynic Acid
|
Diuretic Agent
Loop Diuretic (25% of Na) Most ototoxic, non-sulfa |
|
Thiazide Diuretic and related (5% of Na)
|
Diuretic Agent
Inh Na reabsorption (distal diluting site) → ↑Na, K, Cl excretion, Ca sparing Hypo-K, met alkalosis, Ca sparing (↓ stones), hyperglycemia, hyperlipidemia, hyperuricemia, liver metabolism Tx: HTN, CHF, nephrogenic D. insipidus CI: avoid NSAIDs Oral |
|
Hydrochlorothiazide
|
Diuretic Agent
Thiazide Diuretic and related (5% of Na) DOC: HTN |
|
Chlorthalidone
|
Diuretic Agent
Thiazide Diuretic and related (5% of Na) Slower absorption, longer duration |
|
Metolazone
|
Diuretic Agent
Thiazide Diuretic and related (5% of Na) Diuresis in patients w/reduced GFR |
|
Indapamide
|
Diuretic Agent
Thiazide Diuretic and related (5% of Na) less metabolic complications, CCB like effects |
|
Potassium Sparing Diuretic
|
Diuretic Agent
Inh Na/K exchange (collecting ducts) → ↑Na excretion, K sparing Hyper-K, acute renal failure Tx: CHF, combined with K losing drugs, cirrhosis CI: Hyper-K Oral |
|
Triamterene
|
Diuretic Agent
Potassium Sparing Diuretic |
|
Amiloride
|
Diuretic Agent
Potassium Sparing Diuretic |
|
Aldosterone Antagonists
|
Diuretic Agent
Potassium Sparing Diuretic inh. Aldosterone receptors in distal/collecting duct |
|
Spironolactone
|
Diuretic Agent
Potassium Sparing Diuretic increased survival in CHF, gynecomastia |
|
Eplerenone
|
Diuretic Agent
Potassium Sparing Diuretic Increase survival in CHF, decreased endocrine SE's, CYP3A4 met |
|
Osmotic Diuretic - IV
|
Diuretic Agent
Increased osmotic activity, water retention (prox, loop, CD) (freely filterable agents) Dehydration, hyper-Na CI: severe CHF (early over-expansion of intravascular space) |
|
Mannitol
|
Diuretic Agent
Osmotic Diuretic ↓ intracranial pressure, neuro-sx prophylaxis |
|
Isosorbide
|
Diuretic Agent
Osmotic Diuretic |
|
Glycerin
|
Diuretic Agent
Osmotic Diuretic |
|
Urea
|
Diuretic Agent
Osmotic Diuretic |
|
ADH Antagonist
|
Diuretic Agent
↑ permeability in CD |
|
Demeclocycline
|
Diuretic Agent
ADH Antagonist |
|
Lithium
|
Diuretic Agent
ADH Antagonist |
|
Digitalis (foxglove, Digitalis purpurea, draft evaders, arrow poison) oral
|
CHF Drugs
Inotropic Agents Inh Na/K-ATPase → ↑ IC Na (↓ IC K) → ↓ Ca expulsion so ↑ IC Ca → ↑ contractility ↑ contractility, ↓ HR, ↑ CO & vaso-D in failing hearts only, ↓ AV conduction Tx: CHF, A-fib, A-flutter SE: GI upset → lower dose, cardiac (brady, AV block, bigeminy) → cease therapy; CNS Toxicity: ↑ by Ca, ↓ by K; Tx toxicity w/ K or DigiBind for OD CI(relative): quinidine (↑ serum drug), K losing drugs, ß-blockers, cardioversion (except v-fib) |
|
Digoxin
|
CHF Drugs
Inotropic Agents Digitalis 1 week to steady state |
|
Digitoxin
|
CHF Drugs
Inotropic Agents Digitalis not in US, unfavorable PHK |
|
Ouabain
|
CHF Drugs
Inotropic Agents Digitalis experimental |
|
Phosphodiesterase Inhibitor (inodilators) IV
|
CHF Drugs
Inotropic Agents Inh PDE 3 → ↑cAMP → ↑contractility, vasodilation, ↑ CO ↑ Mortality |
|
Inamrinone
|
CHF Drugs
Inotropic Agents Phosphodiesterase Inhibitor (inodilators) IV |
|
Milrinone
|
CHF Drugs
Inotropic Agents Phosphodiesterase Inhibitor (inodilators) IV |
|
Dobutamine
|
CHF Drugs
Inotropic Agents Sympathomimetic ß-1 agonist, ↑ contractility, mild ↑ HR, IV |
|
Dopamine
|
CHF Drugs
Inotropic Agents Sympathomimetic low dose - ↑renal BF (↑ urine production), ↑CO, Tx: severe refractory CHF; med dose – ß1 agonist, little to no change in BP; high dose – α agonist, vaso-c, ↑BP |
|
Levosimendan, pimobendan
|
CHF Drugs
Inotropic Agents Calcium Sensitizer experimental |
|
Loop agent
|
Drugs w/out Positive Inotropic Effects
Intensive diuresis |
|
Furosemide
|
Drugs w/out Positive Inotropic Effects
Loop agent |
|
torsemide
|
Drugs w/out Positive Inotropic Effects
Loop agent |
|
bumetanide
|
Drugs w/out Positive Inotropic Effects
Loop agent |
|
ethacrynic acid
|
Drugs w/out Positive Inotropic Effects
Loop agent |
|
Thiazides and Related Compounds
|
Drugs w/out Positive Inotropic Effects
Maintenance therapy |
|
Hydrochlorothiazide, etc.
|
Drugs w/out Positive Inotropic Effects
Thiazides and Related Compounds |
|
Metolazone, indapamide, etc
|
Drugs w/out Positive Inotropic Effects
Thiazides and Related Compounds |
|
Triamterene, amiloride
|
Drugs w/out Positive Inotropic Effects
K Sparing (including Aldosterone Antagonists) ↓mortality |
|
Nesiritide (Natrecor)
|
Drugs w/out Positive Inotropic Effects
B Type Natriuretic Peptide Tx: acute decompensated CHF; will ↓PCWP |
|
ACE Inhibitors – oral or IV
|
Drugs w/out Positive Inotropic Effects
↓preload (↓ direct vaso-C), ↓afterload (↓ aldosterone), ↓tissue remodeling SE: dry cough (↑bradykinin), hyper-K CI: bilateral renal artery stenosis, pregnancy ↓mortality, no reflex tachy |
|
Captopril, Enalapril, etc.
|
Drugs w/out Positive Inotropic Effects
ACE Inhibitors |
|
Angiotensin II Receptor Blockers (ARB’s) – oral
|
Drugs w/out Positive Inotropic Effects
Same effects as ACE Inh. w/ out ↑bradykinin and cough |
|
Losartan
|
Drugs w/out Positive Inotropic Effects
Angiotensin II Receptor Blockers (ARB’s) – oral |
|
valsartan
|
Drugs w/out Positive Inotropic Effects
Angiotensin II Receptor Blockers (ARB’s) – oral |
|
candesartan
|
Drugs w/out Positive Inotropic Effects
Angiotensin II Receptor Blockers (ARB’s) – oral |
|
Beta-Blockers
|
Drugs w/out Positive Inotropic Effects
Carvedilol (Coreg; α-1 & ß); Bisoprolol, Metoprolol (Lopressor; ß-1), etc ; ↓mortality, ↓remodeling, ↓renin CI: severe CHF |
|
Vasodilators
|
Drugs w/out Positive Inotropic Effects
SE: reflex tachycardia, fluid retention → give concomitantly w/ ß-blocker and diuretic |
|
Sodium nitroprusside
|
Drugs w/out Positive Inotropic Effects
Vasodilators IV, dilates arteries and veins, tx: acute decomp. CHF |
|
Hydralazine
|
Drugs w/out Positive Inotropic Effects
Vasodilators oral, dilates arteries, ↑CO, SE: SLE |
|
Isosorbide dinitrate, nitroglycerin
|
Drugs w/out Positive Inotropic Effects
Vasodilators sublingual (skip 1st pass), dilates veins →↓preload, develop tolerance so not for long term use |
|
Calcium Channel Blockers
|
Drugs w/out Positive Inotropic Effects
Generally CI in CHF |
|
Amlodipine
|
Drugs w/out Positive Inotropic Effects
Calcium Channel Blockers slightest negative inotropic effect, being studied for use in CHF |
|
Amiodarone
|
Drugs w/out Positive Inotropic Effects
class III antiarrhythmic, may ↑ ejection fraction in CHF |
|
[I-A]
|
Drugs Used in Cardiac Arrhythmias
Class I (Sodium channel blockers) bind open & inactivated Na channels →↑ERP, ↑AP duration, ↑ QRS,QT durations →torsades; |
|
[I-B]
|
Drugs Used in Cardiac Arrhythmias
Class I (Sodium channel blockers) ↓ERP, no Δ QRS,QT |
|
[I-C]
|
Drugs Used in Cardiac Arrhythmias
Class I (Sodium channel blockers) potent, Tx: life threatening ventricular arrhythmias |
|
Quinidine
|
Drugs Used in Cardiac Arrhythmias
Class I (Sodium channel blockers) oral; SE: GI upset(diarrhea), paradoxical tachy-C, torsades & syncope, ↑axn of warfarin, digoxin, & NMJ blockers axn, cinchonism; Tx: broad spectrum, supravent. & vent. arrhythmias [I-A] |
|
Procainamide
|
Drugs Used in Cardiac Arrhythmias
Class I (Sodium channel blockers) CI: AV block [I-A] |
|
Disopyramide
|
Drugs Used in Cardiac Arrhythmias
Class I (Sodium channel blockers) oral ; Tx: ventricular tachycardia; SE: (-)inotropic [I-A] |
|
Lidocaine
|
Drugs Used in Cardiac Arrhythmias
Class I (Sodium channel blockers) [I-B] IV; Tx: ventricular arr; convulsion, bradycardia |
|
Phenytoin
|
Drugs Used in Cardiac Arrhythmias
Class I (Sodium channel blockers) [I-B] oral/IV; Tx: dig. induced vent. arr; Interaxn: protein binding, P-450 |
|
Tocainide
|
Drugs Used in Cardiac Arrhythmias
Class I (Sodium channel blockers) [I-B] oral; Use: pts w/ lido allergy, vent. arr |
|
Mexiletine
|
Drugs Used in Cardiac Arrhythmias
Class I (Sodium channel blockers) [I-B] Tx: painful diabetic neuropathy, vent. arr. in lido resistant pts |
|
Flecainide
|
Drugs Used in Cardiac Arrhythmias
Class I (Sodium channel blockers) [I-C] oral; inh. fast Na channels; ↓AP duration, ↑QRS; Tx: PSVT, A-fib, A-flutter; CI: AV block, CHF |
|
Propafenone
|
Drugs Used in Cardiac Arrhythmias
Class I (Sodium channel blockers) [I-C] oral |
|
Moricizine
|
Drugs Used in Cardiac Arrhythmias
Class I (Sodium channel blockers) [I-C] oral; IA, IB, IC like effects |
|
Propranolol
|
Drugs Used in Cardiac Arrhythmias
Class II (Beta-blockers) Tx: A-fib, A-flutter, PSVT, WPW, selected vent. arr; SE: angina if w/drawn quickly; CI: Raynaud’s |
|
Esmolol (Brevibloc)
|
Drugs Used in Cardiac Arrhythmias
Class II (Beta-blockers) IV; ß-l block; rapid & short axn; Tx: acute PSVT (2nd to adenosine) |
|
Amiodarone
|
Drugs Used in Cardiac Arrhythmias
Class III (prolong repolarization; K channel blockers) oral/IV; class I-IV effects & some α, ß blocking; ↓HR, ↓conduction, ↑QRS,QT; SE: Elvira(brown eyes, gray skin), brady, pulm. fibrosis, less proarrhythmic; Tx: broad arr, ACLS v-tach, v-fib |
|
Sotalol (Betapace)
|
Drugs Used in Cardiac Arrhythmias
Class III (prolong repolarization; K channel blockers) oral; class II & III effects; Tx: vent. & supravent. arr; SE: torsades, ß-block |
|
Bretylium
|
Drugs Used in Cardiac Arrhythmias
Class III (prolong repolarization; K channel blockers) IV; Tx: v-fib, v-tach |
|
Ibutilide, Dofetilide
|
Drugs Used in Cardiac Arrhythmias
Class III (prolong repolarization; K channel blockers) Tx: convert A-fib & A-flutter to normal sinus; SE: torsades |
|
Class IV (Calcium channel blockers)
|
Drugs Used in Cardiac Arrhythmias
Inh L-type Ca channels, ↑ERP, ↓HR, (-)inotrope |
|
Verapamil
|
Drugs Used in Cardiac Arrhythmias
Class IV (Calcium channel blockers) Tx: reentrant supravent. tachy-C; CI: vent. Arr, CHF, AV block, ß-blockers |
|
Diltiazem (Cardizem)
|
Drugs Used in Cardiac Arrhythmias
Class IV (Calcium channel blockers) oral/IV more peripheral effects than verapamil→ ↑CO; Tx: Prinzmetal’s variant angina, stable angina |
|
Bepridil
|
Drugs Used in Cardiac Arrhythmias
Class IV (Calcium channel blockers) |
|
Adenosine
|
Drugs Used in Cardiac Arrhythmias (Misc)
IV; ↑K conductance, ↓cAMP-Ca; Tx: DOC acute PSVT, WPW, reentry |
|
Digoxin
|
Drugs Used in Cardiac Arrhythmias (Misc)
Tx: pre-tx for A-fib before class IA is given |
|
Magnesium
|
Drugs Used in Cardiac Arrhythmias (Misc)
Tx: torsades de pointes, eclampsia |
|
Potassium
|
Drugs Used in Cardiac Arrhythmias (Misc)
tx digoxin toxicity |
|
Hydrochlorothiazide
|
Antihypertensive Agents
Diuretics (Thiazides, Loops, K Sparing) first drug; African Americans; SE: hyperuricemia, ED |
|
Chlorthalidone, Metolazone
|
Antihypertensive Agents
Diuretics (Thiazides, Loops, K Sparing) |
|
Indapamide
|
Antihypertensive Agents
Diuretics (Thiazides, Loops, K Sparing) direct vasodilator |
|
Furosemide (Loop)
|
Antihypertensive Agents
Diuretics (Thiazides, Loops, K Sparing) severe cases, pts w/ renal insufficiency, CHF |
|
Triamterene (K sparing)
|
Antihypertensive Agents
Diuretics (Thiazides, Loops, K Sparing) combo w/ HCTZ and loops |
|
Spironolactone, Eplerenone
|
Antihypertensive Agents
Diuretics (Thiazides, Loops, K Sparing) aldosterone antag. & K sparing |
|
Sympatholytic
|
Activate baroreflexes and retain Na → combine w/ diuretic
|
|
Centrally Acting Drugs
|
Sympatholytic
Centrally Acting Drugs α-2 agonist → ↓symp. tone, ↓renin; SE: sedation; Drug Intraxn: yohimbine |
|
Clonidine
|
Sympatholytic
Centrally Acting Drugs sudden withdrawal → HTN crisis |
|
Methyldopa
|
Sympatholytic
Centrally Acting Drugs SE: hemolytic anemia w/ (+)Coombs test |
|
Mecamylamine
|
Sympatholytic
Ganglion Blocking Agents many SE’s |
|
Adrenergic Neuron-blocking Agents
|
Sympatholytic
↓NE release →↓sympathetic tone |
|
Guanethidine
|
Sympatholytic
Adrenergic Neuron-blocking Agents Replaces NE in vesicles →↓NE release; vaso-D; causes hypertensive crisis in pheochromocytoma (initial large NE bolus release) |
|
Reserpine
|
Sympatholytic
Adrenergic Neuron-blocking Agents Inh NE transport into vesicles |
|
Phenelzine
|
Sympatholytic
MAO Inhibitors |
|
Alpha-1 Adrenergic Blockers
|
Sympatholytic
α-1 block → vaso-D, less reflex tachy; SE: 1st dose phenomenon →hypotension |
|
Prazosin, Doxazosin, Terazosin
|
Sympatholytic
Alpha-1 Adrenergic Blockers |
|
Beta-receptor Blockers
|
Sympatholytic
Beta-receptor Blockers Works well for caucasians & young; Avoid in pts w/ DM, hyperlipid, severe CHF ↓CO, initial ↓renin; SE: reflex ↑renin and tachy-C, and the usual |
|
Propranolol, Nadolol, Timolol
|
Sympatholytic
Beta-receptor Blockers nonselective |
|
Metoprolol (Lopressor), Atenolol, Bisoprolol
|
Sympatholytic
Beta-receptor Blockers ß-1 block |
|
Pindolol
|
Sympatholytic
Beta-receptor Blockers ß-block w/ ISA |
|
Acebutolol
|
Sympatholytic
Beta-receptor Blockers ß-1 block w/ ISA |
|
Labetalol, Carvedilol (Coreg)
|
Sympatholytic
Beta-receptor Blockers α-1 & ß blocker |
|
Direct Acting Vasodilators
|
Sympatholytic
Direct Acting Vasodilators SE: reflex ↑renin & tachy-C, fluid retention → give w/ ß-blocker and diuretic |
|
Sodium nitroprusside
|
Sympatholytic
Direct Acting Vasodilators IV; dilates arteries & veins, Tx: severe HTN, acute decomp. CHF |
|
Hydralazine
|
Sympatholytic
Direct Acting Vasodilators oral; dilates arteries, ↑CO, SE: SLE, angina |
|
Isosorbide dinitrate, nitroglycerin
|
Sympatholytic
Direct Acting Vasodilators sublingual (skip 1st pass); dilates veins →↓preload, develop tolerance so not for long term use |
|
Minoxidil
|
Sympatholytic
Direct Acting Vasodilators oral; arteries; opens K channels; hypertrichosis (topical: Rogaine) |
|
Diazoxide
|
Sympatholytic
Direct Acting Vasodilators IV; arteries; +ATP-K channels; ↓insulin secretion (tx: insulinoma) |
|
Fenoldopam
|
Sympatholytic
Direct Acting Vasodilators IV; arteries; D1 agonist →vaso-D |
|
Verapamil
|
Sympatholytic
Calcium Channel Blockers strongest cardiac effects; ↓HR, (-)inotrope, depress SA/AV; SE:constipation |
|
Diltiazem (Cardizem)
|
Sympatholytic
Calcium Channel Blockers in-between Verapamil and Nifedipine; depress SA and AV node directly |
|
Nifedipine (Procardia), Amlodipine (Norvasc)
|
Sympatholytic
Calcium Channel Blockers strongest vasodilators; reflex tachycardia |
|
ACE Inhibitors – oral or IV
|
Sympatholytic
ACE Inhibitors – oral or IV ↓preload (↓ direct vaso-C), ↓afterload (↓ aldosterone), ↓tissue remodeling Tx: first choice for DM, chronic renal disease, LVH SE: dry cough (↑bradykinin), hyper-K, angioedema CI: bilateral renal artery stenosis, pregnancy |
|
Captopril, Enalapril, etc.
|
Sympatholytic
ACE Inhibitors – oral or IV |
|
Angiotensin II Receptor Blockers (ARB’s) – oral
|
Sympatholytic
Same effects as ACE Inh. w/ out ↑bradykinin, cough, or angio(neurotic)edema |
|
Losartan, valsartan, candesartan
|
Sympatholytic
Angiotensin II Receptor Blockers (ARB’s) – oral |
|
Aliskiren (Tekturna)
|
Sympatholytic
Renin Antagonist like ARB’s |
|
Nitrates and Nitrites – sublingual
|
Vasodilators and the Tx of Angina Pectoris
Most effect on veins; nitrite ion →NO →↑cGMP →vaso-D; Tx: angina, CN poisoning Tolerance develops quickly, Monday disease in explosive manufacturers |
|
Nitroglycerin, Isosorbide dinitrate, Amyl nitrite
|
Vasodilators and the Tx of Angina Pectoris
Nitrates and Nitrites – sublingual (inhaled, euphoria) |
|
Verapamil
|
Vasodilators and the Tx of Angina Pectoris
Calcium Channel Blockers - oral strongest cardiac effects; ↓HR, (-)inotrope, depress SA/AV; SE:constipation |
|
Diltiazem (Cardizem)
|
Vasodilators and the Tx of Angina Pectoris
Calcium Channel Blockers - oral in between Verapamil and Nifedipine; depress SA/AV node directly |
|
Dihydropyridines
|
Vasodilators and the Tx of Angina Pectoris
Calcium Channel Blockers - oral Strongest vasodilators; reflex tachycardia |
|
Nifedipine (Procardia)
|
Vasodilators and the Tx of Angina Pectoris
Calcium Channel Blockers - oral oral/topical; Amlodipine (Norvasc), Isradipine |
|
Beta Blockers
|
Vasodilators and the Tx of Angina Pectoris
↓cardiac workload →↓O2 demand; ↓HR →↑perfusion time; ↓vaso-C |
|
Propranolol (ß), Metoprolol(ß-1), Atenolol(ß-1)
|
Vasodilators and the Tx of Angina Pectoris
Beta Blockers |
|
Phosphodiesterase-5 Inhibitors - oral
|
Vasodilators and the Tx of Angina Pectoris
Phosphodiesterase-5 Inhibitors - oral Inh PDE5(& some PDE6) →↑cGMP; Tx: erectile dysfunction; SE: headache, flushing |
|
Sildenafil (Viagra)
|
Vasodilators and the Tx of Angina Pectoris
Phosphodiesterase-5 Inhibitors - oral ~60 min to axn; CYP3A4; CI: nitrates, α blockers; SE: visual |
|
Vardenafil (Levitra)
|
Vasodilators and the Tx of Angina Pectoris
Phosphodiesterase-5 Inhibitors - oral more selective for PDE5→↓visual SE; faster onset of axn |
|
Tadalafil (Cialis)
|
Vasodilators and the Tx of Angina Pectoris
Phosphodiesterase-5 Inhibitors - oral longest duration of axn; allows for crazy weekends in Vegas |
|
Ranolazine
|
Vasodilators and the Tx of Angina Pectoris (others)
oral; Inh. PFox, inh. Late Na current; ↓LV wall stiffness; Tx: chronic stable angina (not 1st line); SE: CYP3A4, teratogenic |
|
Bosentan
|
Vasodilators and the Tx of Angina Pectoris (others)
oral; endothelin receptor antagonist; only use in severe pulmonary HTN |
|
Cholestyramine, colestipol, colesevelam
|
Agents Used in Hyperlipidemia
Bile Acid Binding Resins binds bile acids to prevent intestinal absorption; ↑LDL receptors (liver)→ ↓serum LDL; SE: constipation, bloating, impair drug absorption; not effective in homozygous familial hyperchol. (no LDL receptors) |
|
Nicotinic Acid
|
Agents Used in Hyperlipidemia
Drugs that Impair Synthesis of Lipoproteins inh. VLDL secretion; ↑HDL; SE: skin flushes, hyperuricemia HMG-CoA reductase inhibitors - ↓LDL synthesis, ↑LDL receptors; CI: pregnancy Also ↓CRP, ↑NO, ↑plaque stability, ↓oxidation, ↓plt. agg; SE: liver, rhabdomyolysis |
|
Lovastatin (Mevacor), Simvastatin (Zocor), Atorvastatin (Lipitor), Rosuvastatin (Crestor), etc
|
Agents Used in Hyperlipidemia
Drugs that Impair Synthesis of Lipoproteins |
|
Fibric Acid Derivatives - oral
|
Agents Used in Hyperlipidemia
PPAR-α ligand →↑lipoprotein lipase activity → VLDL catabolism, ↓TG’s; SE: liver, cholethiasis; ineffective in familial hypercholesterolemia |
|
Gemfibrozil, Clofibrate, Fenofibrate (Tricor)
|
Agents Used in Hyperlipidemia
Fibric Acid Derivatives - oral |
|
Ezetimibe (Zetia)
|
Agents Used in Hyperlipidemia (Others)
blocks intestinal absorption of cholesterol; combine w/ statin |
|
Probucol
|
Agents Used in Hyperlipidemia (Others)
Inh. cholesterol transport from intestine & ↑chol. Excretion, ↓ plaque progression; SE: ↓HDL |
|
d-Thyroxine
|
Agents Used in Hyperlipidemia (Others)
obsolete |
|
Vytorin
|
Agents Used in Hyperlipidemia (Others)
Ezetimibe/Simvastatin |